Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
Effect of probiotic supplementation on behavioral and electrophysiological aspects of memory and learning in ethanol exposed animals
1
9
FA
Amir Hosein
Hadidi-Zavareh
Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, I.R. Iran.
Ramin
Hajikhani
Department of Biology, Tehran North Branch, Islamic Azad University, Tehran, I.R. Iran.
Bahareh
Pakpour
Department of Biology, Faculty of Sciences Tehran Central Branch, Islamic Azad University, Tehran, I.R. Iran.
Mahmoud
Salami
Institute for Basic Sciences, Physiology Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Background: Long lasting exposure to ethanol causes reversible impairment of learning and memory. Gut microbiota imbalance is linked to the neurological disorders. Recent studies indicate that probiotic consumption can relief learning and memory deficit. This study aimed to investigate the effect of probiotic supplementation with intragastric gavage on behavioral and electrophysiological aspects of learning and memory in ethanol exposed animals.
Materials and Methods: In this study, 4 groups including control (CON) and probiotic administered (C+P) groups, the group receiving chronic ethanol (CE) and CE animals receiving probiotic (E+P) were entered the study. The passive avoidance shuttle box test and in vivo electrophysiological experiment were carried out to assess hippocampal baseline filed excitatory postsynaptic potentials (fEPSPs) and long term potentiation (LTP).
Results: Results showed that ethanol impaired memory in the CE rats. It also diminished the slope size of fEPSPs and prevented LTP induction in these animals. The probiotic supplementation improved the behavioral performance in the C+P rats but it did not influence synaptic transmission in this group.
Conclusion: Behavioral but not electrophysiological aspect of cognition cane be sensitive to the probiotic treatment in the ethanol exposed animals.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
Investigating the effect of safranal on Bax and Bcl2 and oxidative stress levels in testis tissue of streptozotocin-induced diabetic rats
10
20
FA
Ghazal
Ataei
Department of Biology, Faculty of Sciences, Payam Noor University, Tehran, I.R. Iran.
Raheleh
Rahbarian
Department of Biology, Faculty of Sciences, Payam Noor University, Tehran, I.R. Iran.
Background: One of the most common endocrine diseases is type 1 diabetes, which causes oxidative stress in testis tissue. Today, in the treatment of diabetes, the tendency toward herbal medicines is increasing day by day. This study aimed to investigate the effects of safranal on Bax and Bcl2 and anti-oxidant levels of streptozotocin-induced diabetic rats.
Materials and Methods: In this experimental study, 24 rats were divided into 4 groups: control, non-treated diabetic and 2 safranal-treated diabetic groups (50, 100 mg/ml, 25 days intraperitoneal injection). The diabetic groups were diabetic with intraperitoneal injection of streptozotocin (STZ) at a concentration of 55 mg/kg body weight of the mouse. On day 25, the testicles were exited to evaluate antioxidant enzymes and Bax and Bcl2. The results were analyzed by using SPSS 20 software, one-way ANOVA and LSD tests
Results: The level of pro-apoptotic Bax and malondialdehyde level in the treated group with a concentration of 100 mg/ml of safranal was significantly reduced compared to the treatment group with a concentration of 50 mg/ml of safranal and control group. However, the level of pro-apoptotic Bcl-2 and glutathione peroxidase, superoxide dismutase and catalase enzymes in the treated group with a concentration of 100 mg/ml of safranal was significantly increased compared to the treatment group with a concentration of 50 mg/ml of safranal and control group (P<0.05); which indicates the effect of safranal concentration. Also, safranal significantly reduced the level of glucose in diabetic rats.
Conclusion: Safranal can improve the antioxidant activity and decrease the damage induced by diabetes in the testis tissue of diabetic rats.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
Comparison of the apoptotic effects of TPSF small molecule and hydroalcoholic extract of Ziziphus spina-christi on cervical cancer cells
21
30
FA
Kiavash
Hoshmndi
Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I.R. Iran.
Elham
Hoveizi
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, I.R. Iran.
Saad
Gooraninejad
Department of Clinical Science, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I.R. Iran.
Mohammadreza
Tabandeh
Stem Cells and Transgenic Technology Research Center (STTRC), Shahid Chamran University of Ahvaz, Ahvaz, I.R. Iran.
Background: Cervical cancer is the third most common cancer in the world. Considering the prevalence of cervical cancer in Iran and unsuccessful treatments, the apoptotic effects of TPSF small molecule investigated in comparison with the hydroelectric extract of Ziziphus Spina-christi leaves on the cervical cancer cell line (HeLa).
Materials and Methods: HeLa cells were cultured in a DMEM medium containing 10% FBS, and treated with different concentrations of TPSF and extract on days 1, 3 and 5. Apoptotic effects were investigated using MTT method, and the morphology of cells was studied by Giemsa staining using invert microscope.
Results: 2 μm concentration of TPSF was determined in 24 hours as IC50 for HeLa cells. The percentage of viability in cells treated with 0.5, 1, 2, 5, and 10 μM TPSF was 78, 63, 50, 42 and 37%. The concentration of 4 mM hydroalcoholic extract was determined as IC50 of HeLa cells in 24 hours. The percentage of viability in treated cells with 1, 2, 4, 6 and 8 mM from the extract of was 73, 61, 50, 41, and 37. The results showed a significant (P≤0.05) decrease compared with the control samples. Also, morphological results showed that the treated cells indicated notable changes such as the shrunk nucleus, damaged membrane, and wrinkled cytoplasm compared with the control sample.
Conclusion: The TPSF is significantly better than the extract of Ziziphus Spina-christi, it can be concluded that small molecules have the smallest amount of cytotoxic effect on HeLa cells and have a greater apoptotic effect.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
The cytotoxic effects of Tolmetin on evaluation of Bax and Bcl2 genes expression level in cervical cancer cells (Hela)
31
37
FA
Sanaz
Norouzi
Department of Genetics, Faculty of Basic Sciences, Eastern Branch, Islamic Azad University, Tehran, I.R. Iran.
Rahim
Ahmadi
Department of Biology, Faculty of Basic Sciences, Hamedan Branch, Islamic Azad University, Hamedan, I.R. Iran.
Sanaz
Pashapour
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Islamic Azad University, Tehran, I.R. Iran.
Background: Tolmetin (C15H15NO3) is a non-steroidal anti-inflammatory drug that exerts its effects by inhibiting prostaglandins and mainly used in the treatment of acute and chronic arthritis, osteoarthritis, and arthritis. Studies have shown that Tolmetin has anti-carcinogenic effects on different cancer cells. Due to the limited studies on the apoptotic effects of Tolmetin, the present study aimed to evaluate the cytotoxic effects of Tolmetin on the evaluation of Bax and Bcl2 gene expression levels in cervical cancer cells (Hela).
Materials and Methods: In this experimental study, the cervical cancer cells were purchased from Pasteur Institute then randomly divided into control group (non-exposure to Tolmetin) and groups exposed to different concentrations of 0.3, 0.6, 1.25, 2.5, 5 and 10 mg/ml of Tolmetin. The cytotoxic effect of Tolmetin was measured using the MTT assay. Also, using Real-Time PCR, expression of BAX, and BCl2 genes was evaluated. Data were analyzed using one-way ANOVA.
Results: The concentrations of 0.3, 0.6, 1.25, 2.5, 5, and 10 mg/ml of Tolmetin resulted in cytotoxic effects on Hela cells. And IC50 dose of 5 mg/ml of Tolmetin increased the expression of the apoptotic Bax gene more than the anti-apoptotic BCL2 gene.
Conclusion: Tolmetin can possibly cause cell death in cervical cancer cells by inducing the Bax gene and the BCL2 anti-apoptosis gene.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
Investigation of the effect of essential oil from Citrus aurantium L. flowers on liver health parameters in a laboratory animal model
38
47
FA
Azadeh
Hamedi
Department of Pharmacognosy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Akram
Jamshidzadeh
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Mahsa
Dana
Student Research Committee, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Ardalan
Pasdaran
Medicinal Plant Processing Research Centre, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Reza
Heidari
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, I.R. Iran.
Background: In Persian food culture, Citrus aurantium L. (bitter orange) flowers and essential oil are consumed as jams or plant distillate in high doses. Some concerns were mentioned in Persian traditional literature about their effects on the liver. This study aimed to investigate the effect of the essential oil from C. aurantium L. flowers on liver health parameters in a laboratory animal model.
Materials and Methods: The essential oil was extracted by Clevenger-type apparatus and analyzed by gas chromatography-mass spectrometry. Six groups of rats (n=5) received intraperitoneal or oral essential oil with the doses of (0.5, 1 or 2 g/kg) for 3 days. The two control groups received olive oil (the vehicle). Forty-eight hours after the last administration, serum and liver samples were prepared and alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and glutathione (GSH) were determined. The liver histopathological changes was investigated.
Results: The main ingredients of the essential oils were linalyl acetate, terpinene-4-ol, linalool and phenethyl alcohol. The intraperitoneal administration of essential oil at doses higher than (1 g/kg) caused a significant increase in AST, ALT and LDH levels. Inflammation of the liver tissue was observed at oral and intraperitoneal doses higher than (1 g/kg).
Conclusion: The changes in AST, ALT and LDH levels showed that at high doses of the essential oil had a mild liver toxicity and the histopathologic data confirmed this. These complication were probably due to direct and non-oxidant toxicity and it was not due to the oxidative stress.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
The effect of Quinacrine on MMP1 Gene Expression in MDA-MB 231 and MCF7 cell lines of breast cancer
48
55
FA
Zahra
Ganjkhanlou
Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Majid
Sirati-Sabet
Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Siamak
Salami
Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Reza
Mirfakhraie
Department of Medical Genetic, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Background: Breast cancer is the most frequent malignancy in women worldwide and occurs when cells in the breast begin to grow out of control. Matrix metalloproteinases (MMP), including MMP1 protein, are important in the progression of various types of cancer. Quinacrine, a derivative of 9-aminoacridine, has been shown to inhibit the growth of several types of cancer cells. In this study, we examined the effect of Quinacrine on MMP1 gene expression in breast cancer cell lines MDA-MB 231 and MCF7. MDA-MB 231 cell line has triple negative breast cancer cells properties.
Materials and Methods: Breast cancer cell lines, MDA-MB 231 and MCF7, were treated with 0.5 µM Quinacrine for 3 days. The dose was selected using MTT assay. Expression of MMP1 gene was quantified by Real-time PCR. Significance of observations were statistically checked by t-test using P<0.05 as the level of significance.
Results: Quinacrine did not have meaningful effect on MMP1 gene expression on MDA-MB 231 and MCF7 cell lines in 0.5 µM concentration for 72 hours.
Conclusion: MMP1 gene is important in metastasis and the present study showed that Quinacrine could not affect the expression of this gene on these breast cancer cell lines.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
Investigate the effect of alcoholic extract of bulbs of narcissus (Narcissus tazetta L.) on indexes of renal function
56
62
FA
Hassan
Morovvati
Department of Basic Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, I.R. Iran.
Nezam
Armand
Postdoctoral Research, University of Tehran, Tehran, I.R. Iran.
Bakground: Narcissus flower has been rich in several different secondary metabolites including essential oils, trinoids, flanoids, phenolic compounds, alkaloids and has bioactive, pharmaceutical properties and is beloved in the perfume industry. This study aimed to investigate the effect of alcoholic extract of bulbs of narcissus on indexes of renal function.
Materials and Methods: In this study, 20 adult male rats were randomly divided into 3 experimental and one control group. Experimental groups received oral bulbs extract of 50, 100 and 150 mg/kg orally for 6 days. Blood samples were taken from all groups of mice on day 7 and renal function tests were performed. Data were analyzed by SPSS software version 21 and the results were presented as mean and standard deviation (Mean±SEM).
Results: Total Proteins decreased significantly (P<0.01) at 100mg/kg Narcissus bulb extract. At the dose of 150 mg/kg of extract, total protein and albumin activity significantly decreased and creatinine significantly increased (P<0.05). Urea at 150 mg/kg concentration also showed a significant increase compared to the control group (P<0.01(. BUN did not change significantly at all doses of the extract compared to the control group.
Conclusion: Significant decrease in total protein and albumin, and significant increase in urea and creatinine, indicate toxicity at high doses of Narcissus bulb extract, which needs further histological studies.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
Histopathological evaluation of the effect of swimming training on ethylene glycol-induced crystal deposition in urinary system and its related damage in rats
63
71
FA
Mahdi
Ezzatifar
Department of Physical Education and Sport Sciences, Faculty of Humanities, Shahed University, Tehran, I.R Iran.
Mohammad
Rahmani
Department of Physical Education and Sport Sciences, Faculty of Humanities, Shahed University, Tehran, I.R. Iran.
Majid
Hassanpour-Ezatti
Department of Biology, Faculty of Basic Sciences, Shahed University, Tehran, I.R. Iran.
Background: The evaluation of exercise effects on the prevention of various diseases is one of the major research fields. In this research, the effect of swimming training on the prevention of kidney crystal deposit and damages induced by ethylene glycol was investigated.
Materials and Methods: In this experimental study, 24 rats were randomly divided into four groups: Control (C), treated with: ethylene glycol 1%(EG), swimming training (SW) and (EG+SW) group that concurrently received ethylene glycol 1%+ swimming practice. Rats in EG and EG+SW groups received 4 weeks drinking water containing1% ethylene glycol. The rats in SW and EG+SW groups were performed swimming training over 6 weeks, three sessions a week for 45 minutes. At the end of the swimming session, rats were euthanized, and kidneys, ureters and bladder tissue samples were histologically evaluated after haematoxylin & eosin staining.
Results: Crystal deposition were observed in all urinary system epithelium surfaces together with renal damages in EG-treated rats, but not observed in urinary system tissue samples of C and SW groups. Renal crystals were detected in renal tissues of EG+SW group was lower than EG group. The total stones were detected in the renal tissue, ureters and bladder and its size in the EG+SW group were significantly lower than EG group (P=0.003). Renal tissue damages of EG+SW group due to ethylene glycol were much less pronounced than EG group.
Conclusion: The swimming training can prevent from renal stones formation induced by ethylene glycol and reduce the tissue damage caused by it.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
The effect of combined training and portulaca oleracea supplementation on body composition indices and physical fitness factors in obese females with non-alcoholic fatty liver
72
79
FA
Narges
Aliniya
Department of Physical Education, Faculty of Humanity Sciences, Islamic Azad University, Rasht Branch, Rasht, I.R. Iran.
Alireza
Elmieh
Department of Physical Education, Faculty of Humanity Sciences, Islamic Azad University, Rasht Branch, Rasht, I.R. Iran.
Mohamadreza
Fadaie-Fhafy
Department of Physical Education, Faculty of Humanity Sciences, Islamic Azad University, Rasht Branch, Rasht, I.R. Iran.
Background: Non-alcoholic fatty liver is the most common liver disease in the world. Due to protective effects and improvement of portulaca oleracea on liver function, this study aimed to determine the effect of combined training and Portulaca oleracea supplement on body composition indices and physical fitness factors in obese females with non-alcoholic fatty liver disease.
Materials and Methods: In this semi-experimental study, 40 obese females with non-alcoholic fatty liver disease were randomly divided into four groups of combined training with portulaca oleracea (n=10), placebo (n=10), portulaca oleracea (n=10) and training (n=10). Training was performed three sessions per week for twelve weeks. The amount of portulaca oleracea consumption was 500 mg per day for twelve weeks. Body composition, physical fittness and liver enzymes variables were assessed at baseline and after the end of interventions. Paired t-test and two-way anova were used.
Results: the results of the present study showed that muscular strength (P=0.00) and vo2 max (P=0.00), body max index (P=0.00), WHR (P=0.00), BF% (P=0.00), ALT (P=0.00), AST (P=0.00) were significant differences between the four groups (P<0.05)
Conclusion: It seems that combined training and taking portulaca oleracea supplementation can improve body composition, physical fitness and liver enzymes in obese females with non-alcoholic fatty liver disease.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
The effect of eye exercises with and without active movements on motor skills in children with amblyopia
80
89
FA
Ensieh Sadat
Askari-Tabar
Department of Sport Motor Behavior, Faculty of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, I.R. Iran.
Mohammad Reza
Shahabi Kaseb
Department of Sport Motor Behavior, Faculty of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, I.R. Iran.
Zahra
Stiri
Department of Sport Motor Behavior, Faculty of Physical Education and Sport Sciences, Hakim Sabzevari University, Sabzevar, I.R. Iran.
Background: Nowadays, one of the exercising methods which lead to improvement in performance and progress on motor skills is eye exercising. Hence, the present research aimed to analyze the effect of eye exercises with and without active movements on motor skills in children with amblyopia.
Materials and Methods: the current paper is a semi-experimental research with a pretest-posttest pattern. A group of 40 children aged 5-8 years with amblyopia were randomly assigned into three groups: eye exercises without active movements, eye exercises with active movements (ocular, ocular and manual, and displacement), and control. The groups were trained in 12 sessions of 30 minutes and the subjects of control group were engaged in their daily activities. The subjects participated in Lincoln Oseretsky's test before and after exercises.
Results: One-way ANOVA and post-test post-hoc Tukey test showed that there was a significant statistical difference between the experimental groups and the control group in the motor skills of children with amblyopia (P<0.05), yet there was no significant statistical difference between experimental groups (P>0.05).
Conclusion: In general, the results of this study showed that eye exercises with and without active movements can improve motor skills in children with amblyopia.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
Comparing power and activity of lower body muscles in two types of multiple sclerosis patients and healthy individuals
90
98
FA
Vahid
Talebi
PhD Student in Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, I.R. Iran.
Zia
Fallah-Mohammadi
Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, I.R. Iran.
Payam
Seadat
Mobility Impairment Research Center, Health Research Institue, Babol University of Medical Sciences, Babol, I.R. Iran.
Sayed Esmaeil
Hoseni-Nejad
Department of Sport Biomechanics and Motor Behavior, Faculty of Sport Sciences, University of Mazandaran, Babolsar, I.R. Iran.
Background: Multiple sclerosis (MS) is a chronic and debilitating disorder that renders degeneration of myelin within Central Nervous System (CNS). This study aimed to investigate the strength and muscle activity in two models of patients with multiple sclerosis in comparison to healthy individuals.
Materials and Methods: In this cross-sectional study, a population of women and men with diseases of MS province of Mazandaran were chosen. After informed consent 45 individuals were included in Relapsing-remitting multiple sclerosis (RR) model, 22 in Secondary progressive multiple sclerosis (SP) model, and 38 as a control group. In order to measure the maximum power of quadriceps muscles Brzycki's formula was used, while dynamometer was employed for assessing trunk muscles. Furthermore, the activities of tibialis anterior, medial gastrocnemius, peroneus longus and soleus muscles were assessed. The data were analysed using one-way analysis of variance, and for comparing intergroup differences Tuckey post-hoc test was utilized.
Results: There was a significant difference between healthy and MS groups (P<0.05). Moreover, the mean activity (P=0.001), maximum activity (P=0.001), co-contraction (P=0.004) and power of muscles (P=0.001) were higher in RR model than in SP model.
Conclusion: Disease progress pattern shows that both power and activity of muscles first increase and then decline. Thus, the RR period can be the best time for maintaining physical condition of MS patients and the initial phases of this debilitating disorder can be decisive in mitigating the future symptoms.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
Editing and psychometrics of the death attitude tool and its association with organ donation after brain death: based on structural equation model
99
108
FA
Farzad
Abbasi
Department of Social Sciences, Faculty of Humanities, University of Kashan, Kashan, I.R. Iran.
Mohammad
Ganji
Department of Social Sciences, Faculty of Humanities, University of Kashan, Kashan, I.R. Iran.
Seyyed Kamaladdin
Mousavi
Department of Social Sciences, Faculty of Humanities, University of Kashan, Kashan, I.R. Iran.
Background: In the modern age, with its increasing reflexivity, death has changed to technical issue, its quality is left to the medical profession, so a new definition of death is introduced as brain death and the possibility of organ transplantation. Therefore, this article aimed to investigate death attitudes and its relationship with organ donation.
Materials and Methods: This descriptive-analytical study examined 475 people over the age of 20 years in Kashan in September 2017 using a population-based random sampling method. The research instrument was a researcher-made questionnaire based on Giddens' theory of late modernity. Data analysis is based on correlation and structural equation design using SPSS and AMOS software.
Results: Among the five dimensions of belief to death, natural belief, with the acceptance of death as the end of life and an inevitable reality as a result of rethinking, awareness of death, medical advances and confidence in experts of the field among the five dimensions of belief to death, had the highest average (3.77 out of 5) and were the most important explanatory variables for both religious (β=0.35, P<0.001) and scientific (β=0.33, P<0.001) dimensions to the organ donation. Model fit indices, Absolute (RMSEA=0.03) Comparative (CFI=0.92) Parsimonious (PRATIO=0.58), showed that the collected data supported the conceptual model well.
Conclusion: The designed tools had good validity and reliability and structural equation showed that organ donation entails the acceptance of death and some kind of trust since in the case of denying the death with either theme of fear or avoidance, the individual cannot accept the organ donation.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
24
1
2020
3
1
Correlation between job mental load and sleep quality with occupational burnout in non-clinical faculty members of Kashan University of Medical Sciences
109
121
FA
Mahdieh
Kaveh
Department of Occupational Health, Health Faculty, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Zahra
Sheikhlar
Department of Occupational Health, Health Faculty, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Hossein
Akbari
Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Hamidreza
Saberi
Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Masoud
Motalebi-Kashani
Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Background: Job burnout is a multifactorial disorder that can occur more frequently in occupations with a high concentration and mental burden, such as faculty members. Quality of sleep is effective on tasks that require new information storage and high mental load. So this study aimed to evaluate the correlation between job mental load and sleep quality with occupational burnout in non-clinical faculty members of Kashan University of Medical Sciences, 2018.
Materials and Methods: This descriptive-correlational study was performed on 102 non-clinical faculty members of Kashan University of Medical Sciences in 2019 and census. Data collection was done using Maslach questionnaires, NASA TLX and Pittsburgh. Statistical analysis was performed using Chi-square, Fisher's exact test, independent t-test and Pearson correlation coefficient.
Results: About 90 percent of faculty members had high mental demand. There was no significant correlation between job burnout with mental job load and sleep quality. But there was a significant correlation between mental job load and sleep quality (R= -0/661, P<0.001). Also, job mental load was higher in faculty members of medical school and emotional exhaustion in faculty members of health faculty than other faculties (P<0.05).
Conclusion: Considering the high level of mental load of teachers and its negative impact on sleep quality, it is recommended that interventional programs aimed at creating proper occupational conditions, strengthening their job ability and teaching the principles of sleep health to reduce mental load of job and improving the sleep quality of teachers, implemented.