Feyz Medical Sciences Journal
مجله علوم پزشکی فيض
Feyz
Medical Sciences
http://feyz.kaums.ac.ir
29
journal29
1029-7855
2008-9821
fa
jalali
1381
1
1
gregorian
2002
4
1
6
1
online
1
fulltext
fa
مقایسه اثرات فلوکستین، نورتریپتیلین و آمی تریپتیلین در مبتلایان به سندرم روده تحریک پذیر
Effects of Fluoxetine, Nortriptyline and Amitriptyline in IBS patients
عمومى
General
پژوهشي
Research
<p align="justify"><strong>Background:</strong> Irritable Bowel Syndrome (IBS) is the most common cause of GI-man visits. Recent trend was seen towards neurotransmitters, however these drugs are expensive. We have determined the effects of fluoxetine, nortriptyline and amitriptyline in IBS patients referred to a private GI clinic in Tehran in 2000.</p><p align="justify"><strong>Materials and Methods:</strong> 173 patients had entered this clinical trial. Diagnosis was made according to the Rome criteria. Patients were concurrently allocated in three groups. Fluoxetine 20 mg/d, amitriptyline 25 mg/d and nortriptyline 25 mg/d were given to individuals of each group, respectively. Pre- and post-test data were collected and recorded in a checklist.</p><p align="justify"><strong>Results:</strong> The study population included 53 cases as the “Constipation group”, 57 as the “Diarrhea group” and 63 as the “Abdominal Pain group”. 50 patients received fluoxetine, 69 nortriptyline and 54 received amitriptyline. Fluoxetine has effectively increased the defecation times of constipated individuals (From 2.56/week to 12/week, P<0.02), but was ineffective for diarrhea individuals (NS). Amitriptyline has improved the defection pattern of constipated and diarrhea individuals (2.31/week to 6.54/week and 17.26/week to 11.79/week, respectively, P<0.02). Nortriptyline had the same effect as amitriptyline (2.67/week to 6.33/week and 20.64/week to 12.23/week, respectively, P<0.01). Fluoxetine and TCAs were significantly improved the abdominal pain, bloating and general performance of affected patients. Amitriptyline has shown more side effects than nortriptyline and fluoxetine (P<0.01).</p><p align="justify"><strong>Conclusion:</strong> Fluoxetine was shown to be more effective than TCAs in constipated patients, however in patients with diarrhea it seems to be less effective. </p>
سندرم روده تحریک پذیر، درمان، فلوکستین، آمی تریپتیلین، نورتریپتیلین
Irritable bowel syndrome, Fluoxetine, Nortriptyline, Amitriptyline
49
55
http://feyz.kaums.ac.ir/browse.php?a_code=A-10-1-329&slc_lang=fa&sid=1
Hossein
Forootan
حسین
فروتن
290031947532846001535
290031947532846001535
Yes
Amir
Taheri
امیر
طاهری
290031947532846001536
290031947532846001536
No
Houman
Hooshangi
هومن
هوشنگی
290031947532846001537
290031947532846001537
No
Hamid Reza
Mohamamdi
حمیدرضا
محمدی
290031947532846001538
290031947532846001538
No