AU - Nadaf-Fahmideh, Mojdeh AU - Gholamrezaei, Shahram AU - Shabani, Ramin TI - Investigation the effect of high intensity interval training (HIIT) with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression in male stroke model rats PT - JOURNAL ARTICLE TA - KAUMS JN - KAUMS VO - 26 VI - 3 IP - 3 4099 - http://feyz.kaums.ac.ir/article-1-4600-en.html 4100 - http://feyz.kaums.ac.ir/article-1-4600-en.pdf SO - KAUMS 3 AB  - Background: Myocardial infarction is an acute condition of myocardial necrosis. So, this study aimed the effect of high intensity interval training with curcumin supplementation on mitochondrial cardiomyocyte PGC-1α and ERR-α gene expression rats. Materials and Methods: 32 male rats were randomly divided into 4 groups of HIIT, supplement, control and HIIT with supplement training in the two groups of high intensity and HIIT with supplement included performing 8 weeks of 4-minute activity with an intensity of 85-90% VO2max. Curcumin was also used at 15 mg / kg. Mitochondrial PGC-1α and ERR-α gene expression was obtained by real-time PCR. Data were analyzed by ANOVA and Shapiro-Wilk at P≤0.05. Results: One-way analysis of variance test showed a significant difference in the expression of mitochondrial cardiomyocyte PGC-1α and ERR-α genes in male myocardial infarction mice in the study groups (P=0.001). The results of Tukey test showed a significant increase in PGC-1α and ERR-α gene expression in the HIIT and HIIT groups with supplementation compared to the control and supplement groups (P=0.001). There was no significant difference between the control and complement groups. Conclusion: The results of this study showed that interval training alone and in interaction with curcumin increases the expression of ERRα and PGC-1α in the heart tissue of male stroke model mice. It seems that interval training and consumption of curcumin can be considered a good way to increase mitochondrial biogenesis and improve heart function. CP - IRAN IN - Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, I.R. Iran. LG - eng PB - KAUMS PG - 264 PT - Research YR - 2022