%0 Journal Article %A Alimoradi, Arash %A Mateen Homaie, Hasan %A Rahmati, Saleh %T The effect of 8 weeks caloric restriction on PLIN5 and ATGL visceral adipose tissue and insulin resistance in type 2 diabetic male rats %J Feyz Medical Sciences Journal %V 26 %N 1 %U http://feyz.kaums.ac.ir/article-1-4536-en.html %R 10.48307/FMSJ.2022.26.1.47 %D 2022 %K Caloric restriction, Perilipins, Adipose triglyceride lipase, Insulin resistance, %X Background: There is a close link between eating fatty foods, the prevalence of obesity and type 2 diabetes. This study aimed to evaluation the effect of 8 weeks caloric restriction on Perilipins (PLIN5) and ATGL visceral adipose tissue and insulin resistance in male diabetic rats. Material and Methods: In this experimental study, 24 male rats were divided into healthy control, diabetic control and diabetic group with caloric restriction. In the caloric restriction group, %40 of the calorie intake was restricted and other groups received the standard food they needed freely for 8 week. The relative expression of prilipine 5 and ATGL protein by Western blotting and insulin resistance were also evaluated using Homa index. Data were analyzed by one-way ANOVA and Tukey's post hoc test. Result: A significant difference was showed between the means of the three groups in comparing the expression of PLIN5 and ATGL proteins. Post hoc test showed a significant increase in PLIN5 and ATGL in the caloric restriction group compared to the healthy and diabetic control group (P=0.001). There was also a significant decrease in insulin and glucose levels in the caloric restriction group compared to the diabetic control group (p = 0.001). Conclusion: Calorie restriction may prevent insulin resistance by acting on the overlying proteins and thus reducing fat accumulation. %> http://feyz.kaums.ac.ir/article-1-4536-en.pdf %P 47-54 %& 47 %! %9 Research %L A-10-4131-1 %+ Department of Exercise Physiology٫ Faculty of Physical Education and Sport Sciences٫ Central Tehran Branch٫ Islamic Azad University٫ Tehran٫ I.R. Iran. %G eng %@ 1029-7855 %[ 2022