TY - JOUR T1 - Investigating the effects of Crocin on pituitary-adrenal axis and thyroid hormones in streptozotocin-induced diabetic male rats TT - بررسی اثر کروسین بر هورمون‌های محور هیپوفیز - آدرنال و هورمون‌های تیروئیدی در موش‌های صحرایی نر دیابتی‌شده با استرپتوزوتوسین JF - KAUMS JO - KAUMS VL - 24 IS - 5 UR - http://feyz.kaums.ac.ir/article-1-4116-en.html Y1 - 2020 SP - 473 EP - 480 KW - Diabetes mellitus KW - Crocin KW - Pituitary gland KW - Adrenal gland KW - Thyroid hormones KW - Rat N2 - Background: Due to the antioxidant effects of saffron in improving diabetes, this study was conducted in order to investigate the effects of crocin on pituitary-adrenal axis and thyroid hormones in diabetic rats. Materials and Methods: In this experimental study, which was performed at Payame Noor University, 28 male rats were divided into 4 groups: control, untreatment diabetic, 2 crocin (50, 100 mg/ml, 25 days intraperitoneal injection)-treated diabetic groups. The diabetic groups obtained with intraperitoneal injection of streptozotocin. Blood sampled from the heart of the rats 25 days after the start of the experimental. Then, pituitary-adrenal axis hormones (cortisol, aldosterone, adrenocorticotropin, and thyroid hormones (TSH, T3, and T4)) were evaluated. The results were analyzed by Kruskal Wallis and LSD tests. Results: Crocin at concentrations of 50 and 100 mg/ml has led to a significant increase in cortisol, aldosterone, and adrenocorticotropin compared to the diabetic rats. Diabetes causes a significant decrease in the levels of thyroid hormones (TSH, T3, and T4). Prescribing crocin at concentrations of 50 and 100 mg/ml has significantly increased the level of thyroid hormones compared to the untreatment diabetic group (P<0.05). Comparing the two concentrations of crocin, the group treated with the concentration of 100 mg/ml has showed a significant increase in the studied indices compared to the group treated with 50 mg/ml of crocin. Also, crosin significantly reduced the level of glucose in diabetic rats. Conclusion: Crocin can increase the level of pituitary-adrenal and thyroid hormones in diabetic male rats. M3 ER -