TY - JOUR T1 - Response of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase enzymes to aerobic exercise and royal jelly in multiple sclerosis patients TT - پاسخ آنزیم‌های آسپارتات آمینوترانسفراز، آلانین آمینوترانسفراز و آلکالین فسفاتاز به تمرین هوازی و مصرف ژل‌رویال در بیماران مالتیپل اسکلروزیس JF - KAUMS JO - KAUMS VL - 23 IS - 4 UR - http://feyz.kaums.ac.ir/article-1-3841-en.html Y1 - 2019 SP - 352 EP - 360 KW - Aerobic exercise KW - Royal Jelly KW - Aspartate eminotransferase KW - Alanine eminotransferase KW - Alkaline phosphatase KW - Multiple sclerosis N2 - Background: Multiple Sclerosis (MS) is associated with many pathological changes and liver damage is one of the most important consequences. This study aimed to investigate the effect of aerobic exercise and the royal jelly on AST, ALT, and ALP enzymes in the patients with multiple sclerosis. Materials and Methods: In this semi-experimental study, 42 MS patients were divided into 4 groups: 1-"Exercise +Royal Jelly" (n=10), 2-"Exercise +Placebo" (n=10), 3-"Royal Jelly" (n=11), 4-"Placebo" (n=11). The Exercise started with an ergometer at 60% HRmax for 6 weeks, 3 sessions per week then increased steadily in the sixth week to 80% HRmax. The daily dose of the royal jelly was 1000 mg. Plasma concentration of the liver enzymes was measured before and after the study. Results: The levels of AST, ALT, and ALP enzymes were significantly reduced compared to the pre-test in the groups of the "Exercise+Royal Jelly" and "Exercise+Placebo" (P<0.05). Also, the ALT enzyme showed a significant decrease in the "Royal Jelly" group. The results of the statistical analysis indicated a significant reduction of the enzymes in the "Exercise+Royal Jelly" and the "Exercise + Placebo" groups compared to the "control" and the "Royal Jelly" groups at the end of the sixth week (P<0.05). Conclusion: It seems that the aerobic exercise and the royal jelly consumption together had the most decreasing effect on serum levels of the liver enzymes in the multiple sclerosis patients, and It has a positive effect on the hepatic enzymes and especially the levels of ALT enzymes in patients. M3 ER -