TY - JOUR T1 - Histological evaluation of the effect of petroleum ether root extract ointment of Onosma dichroanthum Boiss on open skin wound healing in rat TT - ارزیابی بافت شناختی اثر پماد حاوی عصاره پترولیوم اتری ریشه گیاه Onosma dichroanthum Boiss بر التیام زخم باز پوستی در موش‌ صحرایی JF - KAUMS JO - KAUMS VL - 19 IS - 3 UR - http://feyz.kaums.ac.ir/article-1-2692-en.html Y1 - 2015 SP - 190 EP - 196 KW - Onosma dichroanthum Boiss KW - Wound healing KW - Cell count KW - Histology KW - Rat N2 - Background: Onosma dichroanthum Boiss. belongs to the Boraginaceae family and is one of the most important medicinal plants in north of Iran. This study aimed to examine the effect of the petroleum ether root extract ointment of Onosma dichroanthum Boiss. on healing of a surgically induced open skin wound in rats. Materials and Methods: In this study, 54 male adult Wistar rats were randomly allocated into control, vehicle, and experimental groups. A 20-mm cephalocaudal incision was made on the back skin of rats. Rats were sacrificed on days 4, 7 and 14 and histological examination (the number of fibroblasts, neutrophil, blood vessel sections and thickness of epiderm) was performed on skin samples. Results: On day 4, the number of fibroblasts was significantly increased in the experimental group compared to the vehicle (P M3 ER -