TY - JOUR JF - KAUMS JO - Feyz VL - 24 IS - 3 PY - 2020 Y1 - 2020/6/01 TI - Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats TT - اثر ضداضطرابی آلفاپینن در مقایسه با دیازپام در موش صحرایی نر بالغ N2 - Background: Considering the side effects of anti- anxiety drugs, this study investigated the effect of alpha-pinene on anxiety behaviors compared with Diazepam in rats. Materials and Methods In this study, 40 male Wistar rats were divided into 5 groups: control, sham (received alphapinene solvent), the groups received 2 and 4 mg/kg alphapinene, and the group that received diazepam 10 mg/kg. At the end of this period, anxiety was measured using elevated plus maze and concentrations of malondialdehyde, thiol and glutathione peroxidase, in hippocampal tissue. The results were analyzed using one-way ANOVA and Tukey tests. Results: In the groups receiving 2 and 4 mg/kg doses of alpha-pinene significantly increased the percentage of open arm entry (P<0.001) and percentage of time spent in the open arm (P<0.05) (P<0.05). Compared to the control and diazepam groups, administration of alpha-pinene significantly decreased MDA concentration (P<0.001) and significant increase in thiol (P<0.01) (P<0.05) and glutathione peroxidase enzyme activity was evident (P<0.001). Conclusion: Alpha-pinene showed a downward effect on anxiety responses in male rats, similar to anxiolytic effects of diazepam. Alpha-pinene may be potentiated by binding to the position of benzodiazepines in GABA A receptors and exerted its anti-anxiety effect with antioxidant properties. SP - 253 EP - 245 AU - Saeedipour, Sadri AU - Rafieirad, Maryam AD - Department of Biology, Izeh Branch, Islamic Azad University, Izeh, I.R. Iran. KW - Anxiety KW - Alpha-pinene KW - Diazepam KW - Rat UR - http://feyz.kaums.ac.ir/article-1-3863-en.html ER -