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Showing 2 results for Nesfatin
Seyed Hani Davoodi, Majid Vahidian-Rezazadeh, Hamed Fanaei,
Volume 22, Issue 4 (8-2018)
Abstract
Background: Diabetes mellitus is one of the most common metabolic diseases and nettle is a plant that has been introduced as an anti-diabetes medication. Nesfatin-1 is an adipokine secreted from an adipose tissue and involved in the mechanism for glucose metabolism. This study aimed at examining the effect of an 8-week endurance and resistance training program along with the consumption of the hydro-alcoholic extract of nettle on plasma levels of nesfatin-1 in type 1 diabetic rats.
Materials and Methods: In this study, Wistar rats were divided into four groups and diabetes was induced in them by streptozotocin. The nettle extract (1mg/kg) was intraperitoneally injected daily in the "nettle", "endurance+nettle" and "resistance+nettle" groups. The "endurance+nettle" group swam in water for eight weeks, five sessions per week, and each session from 60 to 120 minutes. The "resistance+nettle" group began the exercise with 50, 75, 90, and 100 percent weight on the designed ladder, and then they gradually increased their record. Blood samples were taken directly from the hearts of the animals at the end of the 8th week.
Results: Weight loss was observed in all groups after 8 weeks. The least amount of weights in the "control", "nettle" and "resistance+nettle" groups were significantly lower than those in the beginning of the study (P<0.001). The results showed a significant increase in nesfatin-1 in the "nettle" group compared to the "control" group (P<0.01). Also, this increase was observed in the "endurance+nettle" and "resistance+nettle" groups compared to the "control" group (P<0.001).
Conclusion: Consumption of the nettle extract with exercise can increase the plasma nesfatin-1, which can be effective in controlling diabetes and preventing weight loss due to this disease.
Bahar Darvishi, Elham Dehghan, Ruhollah Ershadi,
Volume 28, Issue 3 (8-2024)
Abstract
Background and Aim: The prevalence of overweight and obesity is increasing dramatically due to unhealthy lifestyles. This study aimed to determine the effects of six weeks of total-body resistance exercise (TRX) combined with purslane supplementation on serum levels of brain-derived neurotrophic factor (BDNF), adropin, and nesfatin in overweight girls.
Methods: In this semi-experimental study, 32 overweight female students aged 16 to 18 years (BMI > 25) from Ganaveh County, Bushehr Province, Iran, were randomly selected. The participants were divided into four groups: exercise, supplement, exercise + supplement, and placebo. The exercise groups performed TRX exercises consisting of 9 to 11 movements for six weeks, with three sessions per week, each lasting 60 minutes. Purslane supplementation was administered as two 500 mg capsules of purslane (Perpin Ala) taken daily after breakfast and lunch. Serum levels of BDNF, adropin, and nesfatin were measured using ELISA at the beginning and end of the six-week study.
Results: The serum levels of BDNF in the exercise + supplement group showed significant differences compared to the exercise, supplement, and control groups (P < 0.05). Additionally, the serum levels of nesfatin were significantly different between the exercise + supplement group and the control group (P < 0.05). However, there were no significant differences in serum levels of adropin among the groups (P > 0.05).
Conclusion: The findings suggest that a combination of TRX exercises and purslane supplementation over six weeks positively affects BDNF and nesfatin levels in young girls, potentially aiding in weight reduction. Further research is needed to explore this area more comprehensively.
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