Background : Nowadays faster healing of surgical wounds to decrease wound complications, especially pain, is a matter of challenge for researchers. Synthetic drugs are more effective for the improvement of wound healing. The main objective of the present study was to evaluate the healing effects of ibuprofen, as a non-selective COX-1 and COX-2 inhibitor, on surgical trauma of stomach in rats.

Materials and Methods : In this experimental study fifteen Wistar rats were randomly assigned into three groups of five animals . To induce trauma, a gastrotomy incision with a width of 1 cm was made in the grater curvature of rat stomach. Thereafter, it was sutured in 2 layers. After the surgery, the experimental group was treated with daily oral ibuprofen for 15 days in a dose of 30 mg/kg (dissolved in 10 ml/kg of DMSO 5%). The placebo and control groups received DMSO (5%) and saline (10 ml/kg), respectively, in the same manner. Histopathologi cal studies for the evaluation of healing were carried out in experimental rats, which were euthanized 15 days after the experiment using hematoxylin-eosin (H&E) and Masson's trichrome staining methods. Wound healing within the groups was compared with the consideration of more effective agents on wound healing (e.g., proliferation of fibroblasts, angiogenesis , re-epithelialization and collagen synthesis ).�Significant differences (p<0.05) among the groups were determined by ANOVA followed by Bonferroni correction.

Results: The numbers of fibroblasts and capillary buds in ibuprofen treated rats were significantly less than those of the healthy control and DMSO control groups (p<0.05). The epithelial gap in treated rats was more than that in the other groups (p<0.05) . There were significant differences in collagen contents of wound healing region between the ibuprofen treated and other experimental groups.

Conclusion: The results of this study indicate that ibuprofen has an inhibitory effect on surgical wound healing of stomach. Therefore, it is not recommended as a postoperative analgesic.

Background: Platelet-rich plasma (PRP) is an autologous product having a high concentration of growth factors well known to stimulate different tissues healing. This study was made to determine the effect of PRP on healing of femoral cancellous bone defect in rabbit.

Materials and Methods: The experiment was conducted on 16 male adult New Zealand white rabbits. The animals were divided into the control group and the treated group including 8 rabbits in each group. Under general anesthesia, using a dental drill, a hole 4 mm in diameter 5 mm in depth was made in the inner aspect of the medial condyle of left femor. In the treated group the created hole was filled with autologous PRP. In the control group, the defect was left untreated. The bone healing was evaluated histopathologically at the end of the first and the second month post surgery. In addition, the samples were assessed histomorphometrically 2 month post surgery.

Results: In the control group, the defect seemed to be filled with adipose tissue including sparse hematogenic cells 1 month after surgery. A poor osteogenic activity and some osteoblasts were visible two month post surgery. In the treated group, within 1 month, a mass of osteoblasts as well as neoformed vessels occupied the gap 1 month after surgery. One month later we observed increased young bone trabeculas in addition to a more compact bone neoformation.

Conclusion: We concluded that PRP with some characteristics such as ostegoenesis and osteoinduction provide a more rapid regeneration of bone defects.