History and Objectives: The regulation of glucose concentration in blood is one of the complex phenomenons, which is effected by several hormonal and neuronal systems. In addition to hormones, neurotransmitters like GABA also play a role in the homeostasis of blood glucose.

Materials and Methods: In this experimental study male albino mice weighting 20-25 grams were used. The effect of GABA agonist and antagonist on the glucose concentration was determined. The effect of various doses of drug on blood glucose was assessed. T-student test and one way variance analysis was carried out on two groups.

Results: The injection of bicucullin and picrotoxin induce a significant increase glucose concentration in two groups (P<0.05). Intraperitoneal injection of muscimol at 1, 2 and 4 mg/kg not only did not reduce blood glucose in the experimental group but that 6 mg/kg augment blood glucose levels to significant levels (P<0.05).

Conclusion: GABA-A through increase plasma insulin and reduced glucagon and somatostatine decreases blood glucose levels. Due to the complexity of GABA-A receptors further work is needed to understand the mechanism.

Background: Preliminary clinical studies have suggested that gabapentin may produce analgesia and reduce the need for opioids in postoperative patients. The aim of the present study was to investigate the opioid-sparing and analgesic effects of gabapentin administered during the first 24h after surgery.

Materials & Methods: In a randomized, single-blind study 196 patients assigned to two groups receiving gabapentin (n=102) or placebo (n=94). Oral gabapentin 1200 mg or placebo, 2h before surgery, followed by oral gabapentin 600 mg or placebo 8, 16 and 24 h after the initial dose. Patients requesting analgesia received it with pethidine at dose of 25 mg ) iv). Total pethidine consumption for each patient was recorded from zero to 24h postoperatively. Pain was assessed on a visual analogue scale (VAS), and vomiting, dizziness and somnolence were assessed.

Results: Gabapentin reduced total pethidine consumption (P<0.001) and postoperative pain as well (P<0.001). It was associated with a significant increase in somnolence (P=0.007) and dizziness (P=0.019), however, no significant difference in vomiting (P=0.075) was observed.

Conclusion: A total dose of 3000 mg gabapentin before and during the first 24h after surgery, reduces pain score and pethidine consumption, and increases the incidence of somnolence and dizziness.