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Showing 3 results for Ciprofloxacin
Mahmoud Nejabat, Mohommad Reza Razeghinejad, Abdolvahhab Alborzi, Volume 6, Issue 1 (4-2002)
Abstract
Background: Bacterial corneal ulcer is a common ophthalmic problem. Still controversies are exist for the treatment of bacterial corneal ulcer, thus, the present study was carried out in Namazi hospital in Shiraz to determine the efficacy and side effects of ciprofloxacin ophthalmic solution 0.3% and compare this with fortified cephazolin-gentamicin. Materials and Methods: It was a clinical trial. Having the physical examination and patient’s history completed, two samples were obtained for culture and smear. Patients were randomly distributed in two groups. One received the standard protocol (Cephazolin 5% and gentamicin 9% ophthalmic solutions) and the other was given ciprofloxacin ophthalmic solution 0.3%. Efficacy was evaluated according to the days of treatment and side effects were surveyed by eye burning and white deposit. Results: Of 45 cases, 6 were excluded due to the altered regimen. Of 39 studied cases, 20 received ciprofloxacin ophthalmic solution 0.3% and the remaining 19 were given standard regimen. Success rate was 90% and 89.5% for the ciprofloxacin and standard regimen, respectively (NS). Eye burning was reported 5% and 36.8%, respectively meanwhile, white deposits were reported in 36.8% of patients who have received standard regimen (P<0.02). Of cultured bacteria, one had shown intermediate resistance to ciprofloxacin, however, resistance was noted to cephalexin and gentamicin. Conclusion: Ciprofloxacin can be a suitable alternative for fortified cephazolin-gentamicin sine it has better outcome and less side effects. Further studies are highly recommended.
Yuonos Soleimani-Asl , Mohammad Zibaei, Farzaneh Firoozeh, Volume 17, Issue 5 (10-2013)
Abstract
Background: Quinolone-resistance in Escherichia coli is ordinarily associated with mutations in the gyrA and parC genes. Plasmid-mediated quinolone resistance (PMQR) was increasingly identified in Enterobacteriaceae family worldwide. The aim of this study was to determine the prevalence of qnrA gene among quinolone-resistant E. coli isolates in Khorram Abad, Iran.
Materials and Methods: In this cross-sectional study, one-hundred forty E. coli isolates were collected from urine samples of the patients. Isolates were screened for ciprofloxacin and nalidixic acid resistance using disk diffusion method according to clinical and laboratory standards institute (CLSI) guidelines. Moreover, PCR was used to evaluate the presence of qnrA gene in quinolone-resistant isolates.
Results: One-hundred sixteen (82.8%) and 63 (43%) out of 140 E. coli isolates showed resistance to nalidixic acid and ciprofloxacin, respectively. The results showed that 14 (12.1%) nalidixic acid- resistant and 9 (14.3%) ciprofloxacin-resistant isolates were positive for qnrA gene.
Conclusion: The identification of qnrA gene among quinolone-resistant E. coli isolates shows that the emergence of PMQR in this region requires serious preventive measures.
Hasan Afzali, Mansoureh Momen-Heravi , Volume 19, Issue 4 (9-2015)
Abstract
Background: An increasing occurrence of antimicrobial resistance among uropathogenic bacterial isolates has complicated the treatment process. The aim of this study was to evaluate the ciprofloxacin and imipenem resistance among uropathogenic bacterial strains isolated from patients with urinary tract infection (UTI).
Materials and Methods: This cross-sectional study was conducted in Kashan from December 2012 to June 2013. A total of 391 urine samples were collected from patients with UTI and identified by standard biochemical tests. Antimicrobial susceptibility pattern screening was determined using the disk diffusion method. The minimum inhibitory concentrations (MICs) of Escherichia coli, Klebsiella spp isolates that were resistant to ciprofloxacin and imipenem by disk diffusion were determined using the E-test method.
Results: Among 391 positive urine cultures, 72.1% were from females and 27.9% from males. Escherichia coli were identified as the most prevalent uropathogenic bacteria. Resistance to ciprofloxacin among E. coli, Klebsiella spp, Enterococcus spp and Acinetobacter baumannii isolates were 37.8%, 22.5%, 36.8% and 62.5%, respectively. Resistance to imipenem was not found in any isolate. We found that all ciprofloxacin resistant E. coli and most (94%) of the ciprofloxacin resistant Klebsiella isolates had ciprofloxacin MICs in the resistance level by the E-test method.
Conclusion: Ciprofloxacin resistance among prevalent uropathogenic bacterial isolates is increasing. However, imipenem is still effective against these bacterial infections and needs to be saved to maintain the effectiveness.
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