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Showing 3 results for Cinnamon
Parvin Hojati, Mehdi Rahnema, Ali Rostami, Hossein Mostafavi,
Volume 26, Issue 5 (10-2022)
Abstract
Background: Cinnamon improves the lipid profile and has antioxidant and protective effects. Therefore, in this study, the effect of cinnamon on the expression of NKCC1 and KCC2 genes in the stroke model of rats receiving a high-fat diet (HFD) was investigated.
Materials and Methods: Thirty-six rats were divided into four groups: control, model (stroke), cinnamon 130 and 260 mg. All groups, except the control group, received HFD for 8 weeks, and then the groups receiving cinnamon were injected with 130 and 260 mg/day of cinnamon for 6 weeks, respectively. The animals were anesthetized and stroke was induced in them with middle cerebral artery occlusion model. After 12 hours, the animals were assessed for body mass index (BMI), stroke volume and expression of NKCC1 and KCC2 genes. One-way ANOVA was used to analyze the data at a significance level of P<0.05.
Results: HFD increased BMI. Cinnamon extract decreased BMI and reduced stroke volume compared to the model group. Decreased expression of NKCC1 and increased expression of KCC2 were significant in stroke hemispheres compared to the model group. The low dose of the extract had a better effect in reducing the expression of genes.
Conclusion: It seems that cinnamon, as a pre-treatment, has valuable and reducing effects on BMI and ischemic strokes caused by obesity, and by modulating the expression of KCC2 and NKCC1 genes, it maintains chlorine ion homeostasis and therefore, it can be considered as a suitable option for the pre-treatment of stroke.
Amir Delshad, Maryam Sadat Dashti,
Volume 26, Issue 6 (12-2022)
Abstract
Background: It seems that physical activity is effective in improving the homeostasis of glucose and blood lipids by increasing the production of circulating levels of Irisin. this research aimed to investigate the simultaneous effect of cinnamon and TRX exercises on the serum levels of Irisin and metabolic status of inactive obese women.
Materials and Methods: The current research was semi-experimental. 40 overweight female volunteers were randomly assigned to four groups of combined exercise (n=10), combined exercise-supplement (n=10), supplement (n=10) and control (n=10). Blood sampling was 24 hours before the start of training period and 48 hours after end of the last session. Then, by using the analysis of covariance (Ancova) test, between-group changes were used and paired correlation T-test was used for intra-group comparison. Data analysis was done by SPSS version 25 software at a significance level of P<0.05.
Results: The findings of this research showed that the combined exercise and cinnamon supplement decreased the serum concentration of insulin and HOME. Also, that increased the level of Irisin, and the values of serum glucose were not significant. but intragroup analysis showed that there was a difference between the averages in exercise group (P=0.048) and exercise-supplement group (P=0.021) in the post-test compared to the pre-test, a significant decrease can be seen.
Conclusion: In this study, Irisin had a negative correlation with fasting blood glucose, BMI, which probably increase can have beneficial effects on glucose regulation, insulin resistance and obesity caused by overweight in women.
Mehdi Abbasi-Moghadam, Vahid Valipour-Dehnou, Mahdieh Molanouri Shamsi,
Volume 26, Issue 6 (12-2022)
Abstract
Background: Considering the hypoglycemic role of cysteine-rich acidic secreted protein (SPARC) and its effect on AMPK phosphorylation and GLUT4 expression, the present study aimed to investigate the effect of aerobic exercise with cinnamon extract supplementation on SPARC, AMPK and GLUT4 levels in type 2 diabetic rats.
Materials and Methods: 35 eight-week-old male Wistar rats were randomly and equally divided into five groups: control (C), diabetes (D), diabetes-supplement (DS), diabetes-exercise (DE), and diabetes-exercise-supplement (DES). The training program was performed 5 sessions per week for 8 weeks. Rats in DS and DES groups received 200 mg/kg of CE daily by gavage, and rats in C and DE groups received water during this period.
Results: Blood glucose was decreased in the DS, DE, and DES groups. SPARC, AMPK, and GLUT4 protein levels and weight significantly reduced in the D group. Also, GLUT4 levels in the DS group increased significantly. However, the SPARC, AMPK, and GLUT4 protein levels were significantly increased in both the DE and DES groups.
Conclusion: CE only increases GLUT4 but exercise increases the SPARC, AMPK, and GLUT4 in diabetic rats. However, exercise with CE have significantly greater effects on the SPARC, AMPK, and GLUT4 in diabetic rats and can be very useful in the treatment of hyperglycemia in diabetic patients.
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