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Showing 5 results for kazemzadeh
Zahra Mahzoon, Sanaz Mirzayan Shanjani, Yaser Kazemzadeh,
Volume 26, Issue 3 (Bimonthly 2022)
Abstract
Background: this study aimed to evaluate the effect of eight weeks of moderate intensity aerobic exercise with Resveratrol supplementation on vascular adhesion molecules (VCAM-1 and ICAM-1) and tumor necrosis factor alpha (TNF-α) in the heart tissue of male rats with type 2 diabetes.
Materials and Methods: The present study was experimental. Statistical samples included 2-month-old male rats weighing 270-230 g. Rats were divided into 5 groups of 6 after familiarity with training protocols; Healthy control, diabetic control (Streptozocin), diabetes supplement, diabetic exercise and exercise + diabetic supplement. 9 mg / kg Resveratrol was given daily to each rat. The study lasted eight weeks.
Results: The amount of TNF-α in the exercise + diabetic supplement group was significantly reduced compared to the diabetic control group (P=0.001), and in the exercise + diabetic supplement group was significantly reduced compared to the diabetic exercise group (P= 0.001). The levels of ICAM-1 and VCAM-1 in the exercise + diabetic supplement group were significantly reduced compared to the diabetic control group (P=0.001). The level of ICAM-1 in the diabetic exercise + diabetic supplement group was significantly reduced compared to the diabetic supplement group and the diabetic exercise group, and the level of VCAM-1 in the exercise + diabetic supplement group was significantly reduced compared to the diabetic supplement group (P=0.001).
Conclusion: The results showed that diabetes increases TNF-α, ICAM-1 and VCAM-1, but exercise and Resveratrol reduce it. Also, a combination of exercise and Resveratrol can lead to better effects.
Masoumeh Mehrabi, Yaser Kazemzadeh, Ali Gorzi, Seyed Ali Hosseini, Saeid Sedaghati,
Volume 26, Issue 6 (Bimonthly 2022)
Abstract
Background: Anabolic-androgenic steroids can cause disturbances in the antioxidant system and some inflammatory markers such as nuclear factor kappa B (NF-KB) and cyclooxygenase-2 (COX-2) in kidney of athletes. So, this study aimed to investigate the effect of eight weeks of testosterone enanthate consumption on antioxidant activity, NF-KB and COX-2 genes expression in kidney tissue of resistance-trained male rats.
Materials and Methods: 24 male rats were divided into three groups: control, training, training + testosterone after a week of familiarization. Rats in the training and training + testosterone groups performed resistance training for eight weeks and five sessions per week. Also, rats in the training + testosterone group received 20 mg/kg/week of testosterone enanthate by intramuscular injection three days a week. One-way analysis of variance was used to analyze the research findings (P≤0.05).
Results: The results of one-way analysis of variance showed that COX-2 gene expression in the training group (P=0.001) and the training + testosterone group (P=0.001) had a significant increase compared to the control group. Also, a significant increase was observed in the Training + testosterone group compared to the training group (P=0.001). NF-kB gene expression in the training group (P=0.003) and the training + testosterone group (P=0.001) compared to the control group significantly was higher. Also, a significant increase was observed in the training + testosterone group compared to the training group (P=0.002).
Conclusion: It seems that intense resistance training and testosterone consumption can lead to an increase in inflammatory factors in the kidney tissue of resistance trained rats.
Jalal Pourjafarian, Yaser Kazemzadeh, Sajjad Arshadi, Abdolali Banaefar, Yahya Mohammadnajad Panahkandi,
Volume 27, Issue 6 (Bimonthly 2023)
Abstract
Background and Aim: Apoptosis is regulated by a complex interplay of gene products that either activate or inhibit this process. This study aimed at assessing the combined impact of nanocurcumin supplementation and resistance training on TERF2 (Telomeric Repeat Binding Factor 2) gene expression and the p21-p53 axis in the muscle tissue of male rats.
Methods: In this experimental study, 24 male Wistar rats were randomly allocated into four groups: a healthy control group, a resistance training group, a nanocurcumin group, and a resistance training + nanocurcumin group. Resistance training was conducted over a 4-week period following a specific protocol. Concurrently, rats in the nanocurcumin groups received 80 mg of the supplement per kilogram of body weight. The expression levels of TERF2, p53, and p21 genes were assessed using the Real-Time PCR method.
Results: The results showed significant differences in the expression levels of TERF2, p53, and p21 genes among the four groups (P<0.05). In the resistance training + nanocurcumin group, the expression of TERF2, p53, and p21 genes was significantly higher compared to the control group (P<0.05). Additionally, p53 gene expression in the resistance training group was significantly higher than in the nanocurcumin supplement group (P<0.05). The combined resistance training and nanocurcumin supplementation did not significantly affect the expression of the TERF2 gene in the muscle tissue of male rats compared to either training or supplementation alone (P<0.05). Furthermore, the synergistic effect of resistance training and supplementation significantly increased the expression of p21 and p53 genes (P<0.05).
Conclusion: Resistance training and nanocurcumin supplementation enhance TERF2 gene expression, potentially reducing telomere shortening and aging. Moreover, the upregulation of p53 and p21 gene expression during resistance training and nanocurcumin supplementation may induce cell cycle arrest and apoptosis.
Zahra Mohseni, Bahram Abedi, Yaser Kazemzadeh,
Volume 28, Issue 2 (Bimonthly 2024)
Abstract
Background and Aim: Various factors in the body, such as omentin-1 (an adipokine of fat tissue) and FGF21 (an endocrine hormone with anti-inflammatory properties), decrease after periods of inactivity. This study aimed to investigate the effects of high-intensity interval training (HIIT) and thyme supplementation on the serum levels of omentin-1 and FGF-21 in sedentary young girls.
Methods: In this clinical trial, 48 young girls were randomly assigned to four groups (n=12 each): HIIT training, thyme supplementation, HIIT + thyme, and control. Serum samples were collected at two time points: pre-test and post-test. Serum levels of omentin-1 and FGF21 were analyzed using specific ELISA kits.
Results: The results showed that there was no significant difference in serum omentin-1 levels before (P=0.505) and after (P=0.542) the test in all four groups. However, post-test FGF-21 levels varied significantly among the groups (P=0.014). Post-test results indicated that FGF-21 levels were significantly higher in the HIIT + Thyme group (P=0.019; effect size=0.465), HIIT group (P=0.049; effect size=0.406), and thyme group (P=0.037; effect size=0.424) compared to the control group. Furthermore, a significant increase in the FGF-21 levels was observed in the thyme (P=0.001), HIIT (P=0.002), and HIIT + thyme (P=0.003) groups after the interventions.
Conclusion: The study suggests that the increase in FGF-21 is a beneficial outcome of HIIT exercises with or without thyme supplementation. Combining HIIT exercises with thyme supplements may lead to a greater increase in FGF-21 levels. However, further research is required to confirm these findings.
Vajihe Varzandeh, Yaser Kazemzadeh, Sanaz Mirzayan Shanjani, Hossein Shirvani,
Volume 29, Issue 0 (7-2025)
Abstract
Background and Aim: Capsaicin, known for its anti-inflammatory and antioxidant properties, plays a critical role in regulating the expression of genes associated with the health of various tissues, including bone. This study aimed to evaluate the effect of eight weeks of capsaicin supplementation on the expression of Runx2 and ALP genes in the bone tissue of aged male Wistar rats.
Methods: In this experimental study, 16 aged male Wistar rats were randomly assigned to two groups: capsaicin supplementation (n=8) and control (n=8). The supplementation group received capsaicin at a dose of 5 mg/kg body weight via oral gavage for eight weeks. Forty-eight hours after the final supplementation dose, the rats were anesthetized with intraperitoneal ketamine and xylazine and subsequently euthanized. Femoral bone tissue samples were collected under sterile conditions, and the expression of Runx2 and ALP genes was assessed using RT-PCR.
Results: Runx2 gene expression was significantly increased in the capsaicin supplementation group compared to the control group (fold change = 3.69%, P=0.038). In contrast, ALP gene expression showed a non-significant increase in the supplementation group (fold change = 4.28%, P=0.029).
Conclusion: Eight weeks of capsaicin supplementation significantly upregulated Runx2 gene expression in the bone tissue of aged rats. Given the pivotal role of Runx2 in osteogenesis, these findings suggest that capsaicin may contribute to improved bone mass in aged rats by enhancing Runx2 expression. Further studies are warranted to confirm these results.
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