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Showing 2 results for Valipour-Chahardah-Charic
Saeed Valipour-Chahardah-Charic , Mahnaz Kesmati, Akbar Vahdati , Seyyed Ebrahim Hoseiny ,
Volume 19, Issue 1 (Bimonthly 2015)
Abstract
Background: Some beneficial effects of zinc oxide nanoparticles (nano ZnO) in medicine have been widely considered in the food and pharmaceutical industries. Despite its beneficial effects and the contradictory oxidant and antioxidant properties of these nano ZnO on cognitive and memory processes, a challenge would be on the medicinal application of these nanoparticles. This study aimed to evaluate the parameters of hippocampal oxidative stress in memory deficits induced by nano ZnO.
Materials and Methods: In this study, 28 adult male Wistar rats (200-250g) were allocated into 4 groups (n=7): control (Saline injection) and three experimental groups with different doses of ZnO (1.25, 2.5 and 5 mg/kg). Long-term memory in an inhibitory avoidance paradigm was examined at one day after the treatment and training. The malondialdehyde (MDA) level as an index of lipid peroxidation and the total thiols (- SH) were evaluated using the biochemical analysis of the hippocampus.
Results: Nano ZnO at 1.25, 5 and also 2.5 mg/kg resulted in the impairment of memory (P<0.001 and P<0.01, respectively) with no change in the locomotor activity a decrease in thiols levels in groups received the higher doses of nano ZnO (2.5 and 5 mg/kg) and an increase in the thiols levels in groups that received the highest dose of nano ZnO wereseen (P<0.001).
Conclusion: It can be concluded that memory impairment induced by nano ZnO in rats may not be attributed to the effects of oxidative stress in the hippocampus.
Maryam Rafieirad, Saeed Valipour-Chahardah-Charic,
Volume 22, Issue 3 (Bimonthly 2018)
Abstract
Background: In recent years, the potential effects of nanoscale materials on the central nervous system have become even more noticeable. The cerebellum is one of the areas of the brain with high absorption of zinc. The aim of this study was to investigate the effects of zinc oxide nanoparticles (NPs) on oxidative stress indices in rat cerebellum in the presence and absence of vitamin C.
Materials and Methods: In this experimental study, male Wistar rats (250-200g) were divided into the following groups (n=7): a normal saline group (control), three groups that received different doses of zinc oxide NPs (1.25, 2.5 and 5 mg/kg), three groups that received different doses of vitamin C (30, 60 and 120 mg/kg) and three groups that received 1.25, 2.5 and 5 mg/kg of zinc oxide NPs combined with 30 mg/kg of vitamin C. Half an hour after receiving the medication, the rats were anesthetized and then their cerebellum was removed and the malondialdehyde (MDA) and thiol groups of the cerebellum region were measured.
Results: The MDA level decreased significantly in the groups received 5mg/kg of zinc oxide NPs, in the groups received different doses of vitamin C, and in the groups received different doses of zinc oxide NPs combined with 30 mg/kg vitamin C compared with the saline group. Total thiol concentration did not change significantly in the different study groups compared to the control group.
Conclusion: Zinc oxide NPs alone or in combination with vitamin C has a reduced effect on oxidative stress in the rat cerebellum.
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