History and Objectives: The regulation of glucose concentration in blood is one of the complex phenomenons, which is effected by several hormonal and neuronal systems. In addition to hormones, neurotransmitters like GABA also play a role in the homeostasis of blood glucose.

Materials and Methods: In this experimental study male albino mice weighting 20-25 grams were used. The effect of GABA agonist and antagonist on the glucose concentration was determined. The effect of various doses of drug on blood glucose was assessed. T-student test and one way variance analysis was carried out on two groups.

Results: The injection of bicucullin and picrotoxin induce a significant increase glucose concentration in two groups (P<0.05). Intraperitoneal injection of muscimol at 1, 2 and 4 mg/kg not only did not reduce blood glucose in the experimental group but that 6 mg/kg augment blood glucose levels to significant levels (P<0.05).

Conclusion: GABA-A through increase plasma insulin and reduced glucagon and somatostatine decreases blood glucose levels. Due to the complexity of GABA-A receptors further work is needed to understand the mechanism.