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Showing 2 results for Parastesh
Behzad Aria, Mohammad Parastesh, Mohamadreza Bayatiani, Leyli Khavari Khorasani,
Volume 26, Issue 4 (Bimonthly 2022)
Abstract
Background: Heart damage is one of the complications of radiotherapy. Due to the favorable effect of exercise training on the heart, this study aimed to investigate the impact of HIIT training on Troponin I and B-type natriuretic peptide in rats undergone radiotherapy.
Materials and Methods: In this experimental study, 24 male Wistar rats were randomly divided into four groups: control, HIIT, radiotherapy, and radiotherapy + HIIT. After anesthesia, radiotherapy was performed using an 11 Gy dose of the linear accelerator. The training program of HIIT and HIIT + radiotherapy groups included 10 weeks of HIIT. To assess the serum levels of troponin-I and B-type natriuretic peptide (BNP), five ml of blood was taken 24 hours after the last training session. One-way ANOVA was used to analyze the data at a significance level of P<0.05.
Results: The results showed that the levels of troponin I in HIIT or radiotherapy + HIIT groups were not significantly different from the control group (P<0.05). But there was a significant difference between the radiotherapy group and the other three groups (P<0.05). Furthermore, no significant difference was observed between the BNP values of any of the groups (P<0.05).
Conclusion: Radiotherapy seems to increase troponin I, but HIIT does not have this effect and even reduces its increased levels. Also, neither HIIT nor radiotherapy has an impact on BNP. Therefore, patients undergoing radiotherapy can use HIIT as an effective therapeutic intervention.
Shahram Azarrang, Mohammad Parastesh, Abbas Saremi,
Volume 28, Issue 2 (Bimonthly 2024)
Abstract
Background and Aim: Diabetes, along with morphine, can lead to metabolic damage in testicular tissue through oxidative stress. This study aimed at investigating the effects of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in the testicular tissue of diabetic rats with acute morphine withdrawal syndrome.
Methods: In this experimental study, 32 male Wistar rats were randomly divided into four groups of eight: 1) diabetes control, 2) morphine + diabetes, 3) diabetes + moderate-intensity endurance training, and 4) morphine + diabetes + moderate-intensity endurance training. Diabetes was induced and morphine was administered to create the acute morphine withdrawal syndrome. The training groups underwent an eight-week endurance training protocol. Oxidant and antioxidant indices, including MDA, TAC, GPX, and SOD, were measured in the testicular tissue at the end of the study.
Results: The concentration of the oxidant index MDA significantly increased in the diabetes group compared to the other groups (P=0.001). However, moderate-intensity endurance training led to a significant decrease in MDA concentration (P=0.001) and a significant increase in the levels of antioxidant indices (TAC, GPX, and SOD) compared to the diabetes group (P=0.001).
Conclusion: Moderate-intensity endurance training could reduce the oxidant index and increase antioxidant indices in the testicular tissue of diabetic rats with morphine withdrawal syndrome. This suggests a potential reduction in infertility complications in these rats.
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