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Showing 2 results for Navardi
Mahnaz Navardi, Ramin Shabani, Shahram Gholamrezaoo Darsara,
Volume 28, Issue 5 (Bimonthly 2024)
Abstract
Background and Aim: Alzheimer's disease (AD) is a major health challenge in the world today. The present study aimed to determine the effect of aerobic exercise and Melissa officinalis extract on the expression of p53, p21, and caspase-3 genes in male rats with AD.
Methods: In this experimental study, 48 rats were randomly divided into 6 groups: control, AD, control + aerobic exercise, AD + aerobic exercise, AD + aerobic exercise + extract, and AD + extract. The AD model was induced by injecting amyloid beta 42-1 into the hippocampus. Aerobic exercise was performed for 8 weeks. Melissa officinalis extract was dissolved in 2 ml of distilled water at a dose of 100 mg/kg body weight and gavaged to rats for 8 weeks. Real-Time PCR was used to determine the expression levels of p53, p21, and caspase-3 genes.
Results: After 8 weeks of aerobic exercise combined with Melissa officinalis extract, the expression of the p21 gene in the intervention groups significantly increased compared to the AD group (P<0.05). Moreover, p53 and caspase-3 were significantly decreased in the AD + aerobic exercise and AD + aerobic exercise + extract groups compared to the AD group (P<0.05).
Conclusion: It seems that aerobic exercise combined with Melissa officinalis extract can inhibit AD by suppressing apoptosis, however, further studies in this field are needed.
Mahnaz Navardi, Ramin Shabani, Shahram Gholamrezaeidarsara,
Volume 29, Issue 1 (Bimonthly 2025)
Abstract
Background and Aim: Alzheimer's disease is a progressive neurodegenerative disorder characterized by the gradual destruction of brain tissue and the onset of severe cognitive impairments. The present study aimed to evaluate the effects of aerobic exercise combined with Melissa officinalis extract on working memory, reference memory, and beta-amyloid deposition in the hippocampal tissue of induced Alzheimer’s male rats.
Methods: In this experimental study, 32 adult male rats were randomly assigned to four groups: control, aerobic exercise, aerobic exercise combined with the extract, and extract alone. The Alzheimer's model was induced by intrahippocampal injection of beta-amyloid 1-42. The exercise protocol was conducted for 8 weeks, with three sessions per week. Working memory was assessed using the eight-arm maze test, and beta-amyloid deposition in the hippocampus was quantified by the ELISA method.
Results: Working memory performance in the intervention groups (aerobic exercise, exercise with extract, and extract alone) showed significant improvement compared to the control group (P<0.05). Additionally, beta-amyloid deposition in the hippocampus was significantly reduced in these groups (P<0.05).
Conclusion: Aerobic exercise and Melissa officinalis extract appear to play a significant role in improving working memory performance in male rats with Alzheimer's disease by reducing beta-amyloid deposition. However, further studies are necessary to confirm these findings.
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