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Showing 3 results for Gharib Naseri
Gholam Reza Komeili, Saleh Zahedi Asl, Mohamamd Kazem Gharib Naseri, Volume 2, Issue 3 (Quaterly 1998)
Abstract
History and Objectives: Due to the role of aluminum on inhibition of calcium channels and use of preparations containing aluminum as anti acid and in order to determine the effect of the veinal injection of aluminum (Systemic) on secretion of gastric acid due to distension, the present study was conducted on anesthetized rats. Materials and Methods: An experimental study on anesthetized tracheostomized rats was undertaken. 1.5ml/100g distension was created. In control group (10 rats) and control groups (8 rats in each group) physiological saline solution placed in gastric cavity. Aluminum chloride (25, 50, 100, 200 ?g aluminum/kg body weight) and saline solution (0.5ml total volume) was injected to experimental and control groups respectively. At 15 minutes intervals, gastric acid content was measured by titration. Results: Significant acid secretion in control group compared to the basal level was absorbed (P<0.001) while distension did not culminate acid secretion in any significant extent. Conclusion: It seems that preparations containing aluminum not only creat buffer effect in gastric cavity (As an antacid) but also it inhibits gastric acid secretion in systematic manner.
Mohamamd Kazem Gharib Naseri, Volume 7, Issue 2 (Quarterly 2003)
Abstract
Background: Zizyphus spina Christi is a native plant of Iran. In traditional medicine, it is mainly used to wash hair. The present study was conducted to determine the effect of hydroacoholic Zizyphus spina christi leaf extract on perfused frog heart contractility and frequency. Materials and Methods: It was an experimental study. The frog heart was cannulated through vena cava and then perfused with standard ringer solution. Having completed the oxygenation and feeding, the ringer solution was extracted through another cannulated tube via left branch of aorta. After recovery, the extract was added to reservoir to achieve the final concentrations of 0.625, 1.25, 2.5, 5, 10, and 20 mg/ml. Percentage changes of contractility and heart rates were recorded before and after adding the extract. Ringer solution, 20-22 degrees centigrade and PH=8.4 was kept on pressure of 5.5cmH2O as a constant venous pressure. For comparison, paired t-test and ANOVA were used. Results: Twenty-five frogs have been studied. The extract could dose-dependently reduce the contractility and heart rate (p<0.0001). Concentration of 20 mg/ml in most cases caused cardiac arrest but contractility was restored by fresh Ringer's solution. Cardiac arrest was not affected by atrial electrical stimulation. Conclusion: It seems as if the extract contains materials that disturb the usage of Ca2+ during contraction mechanism.
Mohammad Kazem Gharib Naseri, Ali Asghar Pilehvaran, Negin Shamansouri, Volume 11, Issue 3 (Quarterly 2007)
Abstract
Background: In spite of the use of industrially prepared drugs for control of diarrhea complications, the attempts to find plants that reduce intestinal smooth muscle motility are going on. The plant celery (Apium Graveolens) from Apiaceae with both nutritional and pharmacological properties contains flavonoids and has hypotensive, antinociceptive, anti- inflammatory and diuretic effects. The aim of the present study was to investigate the antispasmodic effect of celery leaf extract on the rat ileum. Materials and Methods: Celery leaf powder was extracted by maceration in 70% alcohol for 72 hours. A terminal portion of ileum from Wistar male rat was dissected and its contractions were recorded isotonically under one gram tension in an organ bath containing Tyrode solution. t-test, and one and two-way ANOVA were used to compare the results. Results: Extract cumulative concentrations (0.25, 0.5, 1, 2 and 4 mg/ml) reduced the ileum contractions induced by KCl (60 mM) and carbachol (10 μM) dose-dependently (ANOVA, P<0.0001). The antispasmodic effect of extract was not reduced by tissue incubation with propranolol (1 μM, 30 min), naloxone (1 μM, 30 min), L-NAME (100μM, 20 min), glibenclamide (10 μM, 5 min) and tetraethylammonium (1 mM, 5 min). In Ca2+-free with high K+ (60 mM) Tyrode solution, the extract (1mg/ml) reduced the ileum contractions induced by cumulative concentrations of CaCl2 (5-8 mM) dose-dependently (two way ANOVA, P<0.0001). Conclusion : Celery leaf extract inhibited the ileum contractions dose dependently. It seems that voltage dependent calcium channels and receptor-operated calcium channels are involved in this activity, but β-adrenoceptors, opioid receptors, NO, and potassium channels are not involved in this effect. It is possible that apigenin as the celery flavonoid is responsible for this activity.
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