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Background: Matrix Gla protein chelates calcium ions from subendothelial space of the vessels to the circulation and is known to be a calcium scavenger. Thus, this study aimed to evaluate the association of rs1800801G>A polymorphism, serum MGP and stenosis of coronary artery.

Materials and Methods: One hundred and eighty-two subjects who underwent coronary angiography were recruited. The controls (n=70) had normal coronary arteries (up to 5% stenosis). The patients (n=112) subdivided into the three subgroups: single-vessel disease (SVD), two-vessel disease (2VD) and three-vessel disease (3VD). Genotyping was performed by ARMS-PCR and serum MGP measured by ELISA kit.

Results: The serum MGP and genotype distributions showed no significant difference in the patients compared to the control group (P=0.432 and P=0.079, respectively). In addition, there was no significant difference between rs1800801G>A frequency and gender (P=0.404), and also patient subgroups (P=0.473). AA+AG versus GG showed no association with the severity of the disease.

Conclusion: A (rs1800801) polymorphism within the MGP promoter and serum MGP are not related to the stenosis of coronary artery, and total serum MGP can not be used as a diagnostic factor of coronary stenosis.

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Background: Recent research has shown that there is a relationship between exercise and pain threshold and exercise can change the pain threshold. Also, some researchers claim that there is a relationship between the type and intensity of exercise and pain relief. Therefore, this study aimed to compare the effects of aerobic and resistance training on inflammatory pain threshold changes in male rats.
Materials and Methods: In this experimental study, 25 healthy male rats weighing 200-300 g were selected and divided into two experimental groups (aerobic training and resistance training) and a control group. Pre-test and post-test of inflammatory pain threshold was measured by formalin test (pain measurement) and pain test due to stimulation of nerve terminals (tail flick) was performed on the groups. Then, the two experimental groups performed the exercise training program for 6 weeks. Data were analyzed using one- way ANOVA at (P <0.05).
Results: There is a significant difference between the effects of the two training methods (P <0.05). The inflammatory pain threshold was increased in the aerobic group in the Tail-Flick test. But in formalin test, no significant difference was observed between the groups (P <0.05).
Conclusion: Based on the findings of this study, aerobic exercise is effective in increasing the pain threshold. The reducing effects of aerobic exercise on the production of inflammatory factors can be effective and lead to the inflammatory analgesic effect in the animal model. Therefore, further research in this area is recommended.