Evaluating the efficacy of anti-cyclic citrullinated peptide antibody in the diagnosis of rheumatoid arthritis disease
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Batol Zamani , Kamal Esalatmanesh , Alireza Fakhrzad , Hasan Ehteram , Sayyed Gholam Abas Mousavi , Mohsen Arbabi |
, zamani-b@kaums.ac.ir |
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Abstract: (9964 Views) |
Background: Rheumatoid arthritis is one of the most common autoimmune diseases. Early diagnosis can prevent side effects and disability. Anti-cyclic citrullinated peptide antibody is a specific marker to diagnose rheumatoid arthritis. This study was carried out to evaluate the efficacy of anti-cyclic citrullinated peptide in comparison with rheumatoid factor in rheumatoid arthritis patients referred to Behshti Hospital of Kashan city during 2006-7. Materials and Methods: This diagnostic value study was done on 98 randomly selected rheumatoid arthritis patients and 75 patients with other rheumatic diseases. In this study rheumatoid factor titer>35 IU/ml and anti-cyclic citrullinated peptide>6.25 IU/ml were considered positive. Results: Anti-cyclic citrullinated peptide compared to rheumatoid factor had a higher sensitivity (73.5% vs. 69.4%), specificity (88% vs. 84%), positive predictive value (88.9% vs. 85%), and negative predictive value (71.7% vs. 67.7%) for rheumatoid arthritis. The use of rheumatoid factor and anti-cyclic citrullinated peptide test together increased the specificity and positive predictive value for diagnosis of rheumatoid arthritis to 93.3% and 92.4%, respectively. The mean anti-cyclic citrullinated peptide showed a significant difference in Rheumatoid arthritis (46.8 IU/ml( in comparison to non rheumatoid arthritis patients (5.3 IU/ml). Conclusion: Anti-cyclic citrullinated peptide had a better diagnostic value when compared to rheumatoid factor for detection of rheumatoid arthritis. Also combined use of rheumatoid factor and anti-cyclic citrullinated peptide had a higher specificity and positive predictive value than each alone for the diagnosis of rheumatoid arthritis. |
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Keywords: Rheumatoid arthritis, Rheumatoid factor, Anti-cyclic citrullinated peptide, Sensitivity and specificity, Predictive value of tests |
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Full-Text [PDF 168 kb]
(3189 Downloads)
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Type of Study: Research |
Subject:
General Received: 2010/02/1 | Revised: 2010/02/7 | Published: 2010/02/15
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