Background: Kawasaki syndrome is considered as the leading cause of cardiovascular disease among children. The aim of the present study was to determine the prevalence of cardiovascular complications among Kawasaki patients of Yazd province.

Materials and Methods: In this cross-sectional study, the medical documents of all patients (no = 48) referring to Yazd hospitals with a diagnosis of Kawasaki syndrome (during the march 1996 – march 2006) were reviewed and the related demographic, clinical, paraclinical, echocardiographical and therapeutical data were collected through the questionnaire. The obtained data were analyzed using the Chi–square and t-test statistical tools.

Results: Nineteen (39.5%) out of the 48 Kawasaki diagnosed patients had cardiovascular affliction (male 63.2%). All Cardiovascular afflicted patients had coronary aneurysm and a history of more than 5 days fever, whereas this was the case in 89.7% of non- cardiovascular afflicted . ESR mean in cardiovascular afflicted patients was higher than that in the non–afflicted ones (p = 0.04) .

Conclusion: The high affliction of cardiovascular and coronary aneurysm among the Yazd Kawasaki patients is considerable. ESR levels may be helpful in diagnosing the high risk patients for Kawasaki syndrome.