[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
AI::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 29, Issue 7 (Special Issue 2025) ::
Feyz Med Sci J 2025, 29(7): 735-739 Back to browse issues page
Development of nanoparticles as a novel strategy in the treatment of human platyhelminthes infections: A policy brief
Mohsen Arbabi * , Ali Sobhani Nasab
Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran , arbabi4.mohsen@yahoo.com
Abstract:   (174 Views)
Human infections caused by Platyhelminthes belonging to the class of cestodes and trematodes (e.g., taeniasis, hydatidosis, fascioliasis, schistosomiasis) result in significant morbidity, particularly in underdeveloped and underserved communities. While existing anthelmintic drugs like praziquantel and albendazole are effective against these diseases, they encounter challenges such as limited access issues, infection recurrence, and increasing concerns about drug resistance. This policy brief explores the use of nanoparticles as an innovative and targeted approach to drug delivery, offering a promising solution to overcome therapeutic obstacles, including drug resistance and pharmacokinetic limitations, in treating human infections caused by cestodes and trematodes.
 
Keywords: Nanoparticles, Infection, Platyhelminthes, Policy brief
Full-Text [PDF 327 kb]   (35 Downloads)    
Type of Study: Policy Brief | Subject: medicine, paraclinic
Received: 2025/12/20 | Revised: 2026/04/8 | Accepted: 2026/01/12 | Published: 2026/03/15
References
1. Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. Helminth infections: the great neglected tropical diseases. J Clin Invest. 2008; 118(4): 1311-21. doi: 10.1172/JCI34261. PMid:18382743 PMCid:PMC2276811
2. Del Brutto OH. Human Neurocysticercosis: An Overview. Pathogens. 2022;11:1212. doi: 10.3390/pathogens11101212. PMid:36297269 PMCid:PMC9607454
3. Badwaik N, Gharde P, Shinde RK, Tayade HT, Navandhar PS, Patil M. Hydatid Cyst or Echinococcosis: A Comprehensive Review of Transmission, Clinical Manifestations, Diagnosis, and Multidisciplinary Treatment. Cureus. 2024; 16(7): e63713. doi: 10.7759/cureus.63713.
4. Lo NC, Bezerra FSM, Colley DG, Fleming FM, Homeida M, Kabatereine N, et al. Review of 2022 WHO guidelines on the control and elimination of schistosomiasis. Lancet Infect Dis. 2022; 22(11):e327-35. doi: 10.1016/S1473-3099(22)00221-3. PMid:35594896
5. Tanabe MB, Caravedo MA, White AC Jr, Cabada MM. An Update on the Pathogenesis of Fascioliasis: What Do We Know? Res Rep Trop Med. 2024; 15: 13-24. doi: 10.2147/RRTM.S397138. PMid:38371362 PMCid:PMC10874186
6. Saelens G, Gabriël S. Currently Available Monitoring and Surveillance Systems for Taenia spp., Echinococcus spp., Schistosoma spp., and Soil-Transmitted Helminths at the Control/Elimination Stage: A Systematic Review. Pathogens. 2020; 9(1):47. doi: 10.3390/pathogens9010047. PMid:31935916 PMCid:PMC7168685
7. Hong ST. Albendazole and Praziquantel: Review and Safety Monitoring in Korea. Infect Chemother. 2018; 50(1):1-10. doi: 10.3947/ic.2018.50.1.1. PMid:29637747 PMCid:PMC5895825
8. Nixon SA, Welz C, Woods DJ, Costa-Junior L, Zamanian M, Martin RJ. Where are all the anthelmintics? Challenges and opportunities on the path to new anthelmintics. Int J Parasitol Drugs Drug Resist. 2020;14:8-16. doi: 10.1016/j.ijpddr.2020.07.001. PMid:32814269 PMCid:PMC7452592
9. Hamamoto Filho PT, Rodríguez-Rivas R, Fleury A. Neurocysticercosis: A Review into Treatment Options, Indications, and Their Efficacy. Res Rep Trop Med. 2022;13:67-79. doi: 10.2147/RRTM.S375650. PMid:36601353 PMCid:PMC9807125
10. Crellen T, Walker M, Lamberton PL, Kabatereine NB, Tukahebwa EM, Cotton JA, et al. Reduced Efficacy of Praziquantel Against Schistosoma mansoni Is Associated With Multiple Rounds of Mass Drug Administration. Clin Infect Dis. 2016;63(9):1151-9. doi: 10.1093/cid/ciw506. PMid:27470241 PMCid:PMC5064161
11. Tiwari R, Gupta RP, Singh VK, Kumar A, Madhukar P, Sundar S, et al. Nanotechnology-Based Strategies in Parasitic Disease Management: From Prevention to Diagnosis and Treatment. ACS Omega. 2023;8(45):42014-27. doi: 10.1021/acsomega.3c04587. PMid:38024747 PMCid:PMC10655914
12. Qadeer A, Ullah H, Sohail M, Safi SZ, Rahim A, Saleh TA. Potential application of nanotechnology in the treatment, diagnosis, and prevention of schistosomiasis. Front Bioeng Biotechnol. 2022; 10: 1013354. doi:10.3389/fbioe.2022.1013354. PMid:36568300 PMCid:PMC9780462
13. Yagublu V, Karimova A, Hajibabazadeh J, Reissfelder C, Muradov M, Bellucci S, et al. Overview of Physicochemical Properties of Nanoparticles as Drug Carriers for Targeted Cancer Therapy. J Funct Biomater. 2022;13(4):196. doi: 10.3390/jfb13040196. PMid:36278665 PMCid:PMC9590029
14. Benelli G. Gold nanoparticles - against parasites and insect vectors. Acta Trop. 2018;178:73-80. doi: 10.1016/j.actatropica.2017.10.021. PMid:29092797
15. Heshmati F, Sangar SG, Amoozadehsamakoosh A, Azadi E, Komeili N. The Role of Metallic Nanoparticles in the Prevention and Treatment of Parasitic Diseases in Poultry. J World's Poult Sci. 2023;2(3):13-9. doi: 10.58803/jwps.v2i3.15.
16. Soleymani N, Sadr S, Santucciu C, Rahdar A, Masala G, Borji H. Investigating the Therapeutic Effects of Albendazole, Mebendazole, and Praziquantel Nanocapsules in Hydatid Cyst-Infected Mice. Pathogens. 2025;14(3):240. doi: 10.3390/pathogens14030240. PMid:40137725 PMCid:PMC11944628
17. Sun Y, Chen D, Pan Y, Qu W, Hao H, Wang X, et al. Nanoparticles for antiparasitic drug delivery. Drug Deliv. 2019;26(1):1206-21. doi: 10.1080/10717544.2019.1692968.PMid:31746243 PMCid:PMC6882479
18. Farhadi M, Haniloo A, Rostamizadeh K, Ahmadi N. In vitro evaluation of albendazole-loaded nanostructured lipid carriers on Echinococcus granulosus microcysts and their prophylactic efficacy on experimental secondary hydatidosis. Parasitol Res. 2021;120(12):4049-60. doi: 10.1007/s00436-021-07343-0. PMid:34669034
19. Pensel PE, Gamboa GU, Fabbri J, Ceballos L, Bruni SS, Alvarez LI, et al. Cystic echinococcosis therapy: Albendazole-loaded lipid nanocapsules enhance the oral bioavailability and efficacy in experimentally infected mice. Acta Trop. 2015; 152:185-94. doi: 10.1016/j.actatropica.2015.09.016.PMid:26409727
20. Yetisgin AA, Cetinel S, Zuvin M, Kosar A, Kutlu O. Therapeutic Nanoparticles and Their Targeted Delivery Applications. Molecules. 2020;25(9):2193. doi: 10.3390/molecules25092193. PMid:32397080 PMCid:PMC7248934
21. Ciftci F, Özarslan AC, Kantarci IC, Yelkenci A, Tavukcuoglu O, Ghorbanpour M. Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment. Molecules. 2020;25(9):2193. doi: 10.3390/molecules25092193. PMid:32397080 PMCid:PMC7248934
22. Ng'etich AI, Amoah ID, Bux F, Kumari S. Anthelmintic resistance in soil-transmitted helminths: One-Health considerations. Parasitol Res. 2023;123(1):62. doi: 10.1007/s00436-023-08088-8. PMid:38114766 PMCid:PMC10730643
23. Qi SS, Sun JH, Yu HH, Yu SQ. Co-delivery nanoparticles of anti-cancer drugs for improving chemotherapy efficacy. Drug Deliv. 2017; 24(1):1909-26. doi: 10.1080/10717544.2017.1410256. PMid:29191057 PMCid:PMC8241150
24. Khalifa HO, Oreiby A, Mohammed T, Abdelhamid MAA, Sholkamy EN, Hashem H, et al. Silver nanoparticles as next-generation antimicrobial agents: mechanisms, challenges, and innovations against multidrug-resistant bacteria. Front Cell Infect Microbiol. 2025;15:1599113. doi: 10.3389/fcimb.2025.1599113. PMid:40895297 PMCid:PMC12390974
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: IR.KAUMS.MEDNT.REC.1398.060



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Arbabi M, Sobhani Nasab A. Development of nanoparticles as a novel strategy in the treatment of human platyhelminthes infections: A policy brief. Feyz Med Sci J 2025; 29 (7) :735-739
URL: http://feyz.kaums.ac.ir/article-1-5470-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 29, Issue 7 (Special Issue 2025) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.12 seconds with 46 queries by YEKTAWEB 4741