History and Objectives: Due to the prevalence of antibiotic resistance in bacterial infection and lack of information on such patients residing in Kashan, the present report will address the factors involved in urinary infection and prevalence of the antibiotic resistance among patients referred to the Shaheed Beheshti hospital of Kashan in 1995-1997.

Materials and Methods: The study was carried out on the available data. Patient’s records with positive urine culture test and antibiotic sensitivity test were considered. The prevalence of urinary tract infection were studied and antibiotic sensitivity was determined for the years of the study. A descriptive analysis of data was presented.

Results: E.coli clebcia and enterobacter were the most prevalence type of infection respectively. The pattern of infection was similar for the 3 years of study. Resistance to ampicillin was augmented from 76% to 81% and to 90%. The resistance to co-trimoxazole was from 56% to 60% to 66% respectively. Resistance for cephalothin was increased from 48% to 51% to 59% respectively. The annual rate of the 3 antibiotic resistance was 3-9%.

Conclusion: It seems that the prevalence of the antibiotic resistance is fairly high and a trend of increasing resistance was observed for 3 antibiotics. The present situation requires annual assessment of antibiotic resistance among the patients. This will provide ample information for physicians treating urinary tract infection.