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Investigating the effect of high intensity interval swimming on Alpha-synuclein and cAMP response element-binding protein gene expression in rats with Parkinson's disease
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Mehdi Javidi    , Mehrzad Moghadasi , Mohammdamin Edalatmanesh , Mehdi Noora |
| Shiraz branch, Islamic Azad University, Shiraz, Iran , mehrzad.moghadasi@gmail.com |
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Abstract: (99 Views) |
Background and Aim: Parkinson’s disease (PD) is characterized by the increase of α-synuclein (α-Syn) and decrease of cAMP-responsive element-binding protein (CREB) in brain. The effect of exercise on α-Syn and CREB in PD is not well known. The aim of present study was to investigating the effect of high intensity interval swimming on α-Syn and CREB gene expression in rats with PD.
Methods: Twenty-one male Wistar rats (age 8 – 10 weeks) were selected. After PD induction with reserpine, fourteen rats were divided into PD group or training group randomly. Seven remaining rats were included in the healthy control group. The rats in the training group, performed high intensity interval swimming, including 20 times of 30 seconds of swimming with 30 seconds of rest between each time for 6 weeks. α-Syn and CREB gene expression were measured 48h after the last session of training.
Results: The study results indicated that α-Syn gene expression was higher in the PD group compare to the healthy group and training group (p=0.001 and p=0.002 respectively); while, no significant difference was observed between training group and healthy group (p=0.2). CREB gene expression was lower in the PD group compare to the healthy group and training group (p=0.006 and p=0.003 respectively); while, no significant difference was observed between training group and healthy group (p=0.6).
Conclusion: High intensity interval swimming by decreasing α-Syn and increasing CREB gene expression may be improve dopaminergic neurons survival and be effective for PD.
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| Keywords: Parkinson's disease, High intensity interval swimming, α-synuclein, CREB |
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Type of Study: Research |
Subject:
General
Received: 2024/01/7 | Revised: 2024/04/30 | Accepted: 2024/04/30
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