[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Biochemistry and Nutrition in Metabolic Diseases
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 27, Issue 6 (Bimonthly 2023) ::
Feyz Med Sci J 2023, 27(6): 619-628 Back to browse issues page
Impact of endurance training and Citrus aurantium L.var. amara Engl. (CAVAO) consumption on lipid profile, intercellular adhesion molecules-1 (ICAM-1) and vascular cell adhesion molecules-1 (VCAM-1) in aged Sprague-Dawley rats
Nasrin Rabiei Dargah , Saeed Keshavarz * , Seyed Ali Hosseini , Hamid Zahedi
Department of Physical Education and Sport Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran , saeed_keshavarz57@yahoo.com
Abstract:   (786 Views)
Background and Aim: Aging is often accompanied by inflammation and lipid abnormalities. This study aimed at investigating the effects of endurance training combined with Citrus aurantium L.var. amara Engl. (CAVAO) consumption on the lipid profile, intercellular adhesion molecules-1 (ICAM-1), and vascular cell adhesion molecules-1 (VCAM-1) in aged Sprague-Dawley rats.
Methods: In this experimental study, 35 aged Sprague-Dawley rats were divided into 7 groups: high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), HIIT with CAVAO (HIIT+CA), MICT with CAVAO (MICT+CA), CAVAO alone (CA) (300 mg/kg/day), control, and sham. Over eight weeks, HIIT was conducted at 85-110% VO2max intensity, while MICT was performed at 65-75% VO2max intensity. Lipid profiles were assessed using a kit, and ICAM-1 and VCAM-1 gene expressions were analyzed via RT-PCR.
Results: HIIT, MICT, HIIT+CA, MICT+CA, and CA resulted in a significant increase in HDL levels, with HIIT showing the most pronounced effect (P<0.05). LDL decreased significantly in all groups except CA (P<0.05). The HIIT+CA group exhibited a greater reduction in TG levels compared to the CA group. Cholesterol levels decreased in the HIIT, MICT+CA, and CA groups, with the CA group demonstrating a more substantial reduction than the HIIT and MICT+CA groups (P<0.05). VCAM-1 levels increased in all groups, while ICAM-1 levels decreased in all groups except HIIT+CA, where a more significant reduction in ICAM-1 was observed compared to other groups (P<0.05).
Conclusion: The combination of endurance training interventions and CAVAO antioxidant supplementation (HIIT, MICT, HIIT+CA, MICT+CA, CA) may offer cardiac protection against hyperlipidemia due to their antihyperlipidemic effects. The interactive effect of HIIT+CA and MICT+CA appears to have a more favorable impact on lipid profiles and ICAM-1 levels.
Keywords: Training, Citrus aurantium, Lipid Profiles, Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, Inflammation, Aging
Full-Text [PDF 535 kb]   (282 Downloads)    
Type of Study: Research | Subject: General
Received: 2023/05/12 | Revised: 2024/02/19 | Accepted: 2023/12/24 | Published: 2024/02/13
References
1. Hopkin S, Lord J, Chimen M. Dysregulation of leukocyte trafficking in ageing: Causal factors and possible corrective therapies. Pharmacological Res 2021;163:105323 doi:10.1016/j.phrs.2020.105323 PMid:33276099
2. Chung KW. Advances in Understanding of the Role of Lipid Metabolism in Aging. Cells 2021; 10 (4):880 doi:10.3390/cells10040880 PMid:33924316 PMCid:PMC8068994
3. Salminen A. Increased immunosuppression impairs tissue homeostasis with aging and age-related diseases. J Mol Med 2020:1-20 doi:10.1007/s00109-020-01988-7 PMid:33025106 PMCid:PMC7782450
4. Qin S, Huang L, Gong J, Shen S, Huang J, Ren H, Hu H. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J 2017;16(1):1-10 doi:10.1186/s12937-017-0293-y PMid:29020971 PMCid:PMC5637251
5. Park J, Willoughby DS, Song JJ, Leutholtz BC, Koh Y. Exercise-induced changes in stress hormones and cell adhesion molecules in obese men. J Inflammation Res 2018;11:69 doi:10.2147/JIR.S158294 PMid:29535548 PMCid:PMC5836718
6. Asad M, Sistani M, Barzegari A. The effect of eight weeks of continuous endurance training on ICAM-1 and VCAM-1 expression in the heart tissue of rats. J Babol Univ Med Sci 2019;21(1):230-6.
7. Ryan AS, Li G, Hafer-Macko C, Ivey FM. Resistive training and molecular regulators of vascular-metabolic risk in chronic stroke. J Stroke Cerebrovasc Dis. 2017; 26(5): 962-8. doi:10.1016/j.jstrokecerebrovasdis.2016.11.003 PMid:27955950 PMCid:PMC5409877
8. Hasanzadeh Dolatabadi F, Jalali Dehkordi K, Taghian F, Hoseini S. The effect of eight weeks of aerobic training with Propolis on some mitochondrial biogenesis markers in cardiac tissue of ovariectomized diabetic rats. Armaghane Danesh. 2022; 27(2): 655-92 doi:10.52547/armaghanj.27.2.155
9. Salehi Rad E, Mousavi Sadati SK. The effect of 8 weeks of Pilates exercises on old menopausal women's psychological health. J Res Sport Rehabil 2023;10(20):41-9.
10. Nasirzadeh MR, Nourazar A, Khayat Nouri MH, Roshangar L. The Effect of Methanolic Soy Extract on Heart Tissue Changes in Ovariectomized Rats. J Ardabil Univ Med Sci 2012; 12(1): 97-105.
11. Leitão L, Marocolo M, de Souza HL, Arriel RA, Vieira JG, Mazini M, et al. Multicomponent Exercise Program for Improvement of Functional Capacity and Lipidic Profile of Older Women with High Cholesterol and High Triglycerides. Int J Environ Res Public Health 2021;18(20):10731 doi:10.3390/ijerph182010731 PMid:34682474 PMCid:PMC8535711
12. Mirzaei M. Comparison of the effect of emotional intelligence training and yoga exercises on social anxiety of women with depression. Novel Clin Med 2023; 2(2): 82-91. doi: 10.22034/ncm.2023.394935.1082
13. Mahmoud AM, Hernandez Bautista RJ, Sandhu MA, Hussein OE. Beneficial effects of citrus flavonoids on cardiovascular and metabolic health. Oxidative Med Cellular Longevity 2019; 2019 doi:10.1155/2019/5484138 PMid:30962863 PMCid:PMC6431442
14. Shekarchizadeh‐Esfahani P, Arab A, Ghaedi E, Hadi A, Jalili C. Effects of cardamom supplementation on lipid profile: A systematic review and meta‐analysis of randomized controlled clinical trials. Phytotherapy Res 2020;34(3):475-85 doi:10.1002/ptr.6543 PMid:31755188
15. Hamedi A, Jamshidzadeh A, Dana M, Pasdaran A, Heidari R. Investigation of the effect of essential oil from Citrus aurantium L. flowers on liver health parameters in a laboratory animal model. Feyz Med Sci J 2020;24(1):38-47
16. Shykholeslami Z, Abdi A, Hosseini SA, Barari A. Effect of Continuous Aerobic Training with Citrus Aurantium L. on Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinases Gene Expression in the Liver Tissue of the Elderly Rats. J Ilam Univ Med Sci 2021;29(6):81-9doi:10.52547/sjimu.29.6.81
17. He W, Li Y, Liu M, Yu H, Chen Q, Chen Y, et al. Citrus aurantium L. and its flavonoids regulate TNBS-induced inflammatory bowel disease through anti-inflammation and suppressing isolated jejunum contraction. Int J Mol Sci 2018;19(10):3057 doi:10.3390/ijms19103057 PMid:30301267 PMCid:PMC6213068
18. Yazdanparast Chaharmahali B, Azarbayjani MA, Peeri M, Farzanegi Arkhazloo P. The Effect of Moderate and High Intensity Interval Trainings on Cardiac Apoptosis in the Old Female Rats. Report Health Care 2018;4(1):26-35.
19. Zanetti HR, da Cruz LG, Lourenço CLM, Ribeiro GC, de Jesus Leite MAF, Neves FF, et al. Nonlinear resistance training enhances the lipid profile and reduces inflammation marker in people living with HIV: a randomized clinical trial. J Phys Act Health 201 ; 13 (7): 765-70 doi:10.1123/jpah.2015-0540 PMid:26901242
20. Ouerghi N, Ben Fradj MK, Khammassi M, Feki M, Kaabachi N, Bouassida A. Plasma chemerin in young untrained men: association with cardio-metabolic traits and physical performance, and response to intensive interval training. Neuroendocrinol Lett 2017;38(1):59-66.
21. Bakheet EN, Serry Z, Mohamed ME. Impact of whole body vibration versus resistive exercise training on lipid profile in elderly. World J Med Sci 2016; 13:1-8.
22. Magalhães JP, Santos DA, Correia IR, Hetherington-Rauth M, Ribeiro R, Raposo JF, et al. Impact of combined training with different exercise intensities on inflammatory and lipid markers in type 2 diabetes: A secondary analysis from a 1-year randomized controlled trial. Cardiovasc Diabetol 2020; 19(1):1-11 doi:10.1186/s12933-020-01136-y PMid:33028418 PMCid:PMC7539392
23. Miri A, Roshanzadeh M, Masoudi R, Kheir, S, Tajabadi A, Davoodvand S. Comparison of the effect of local cold therapy and hand and foot massage on blood pressure in post-operative patients. Novel Clin Med 2023; 2(1): 24-31. doi: 10.22034/ncm.2023.380439.1060
24. Mattusch F, Dufaux B, Heine O, Mertens I, Rost R. Reduction of the plasma concentration of C-reactive protein following nine months of endurance training. Int J Sports Med 2000; 21(01): 21-4 doi:10.1055/s-2000-8852 PMid:10683094
25. Jafari M, Pouryamehr E, Rabbani H, Heydari M. Effect of Eight Weeks High Intensity Interval Training (HIT) on Adhesive Molecules in Obese Young Women. J Appl Exercise Physiol 2020; 16(31): 145-54.
26. Yoshimura Y, Nakamura H, Shimomura M, Iide K, Oda K, Imamura H. Effects of high-intensity circuit training on calcaneal bone status in collegiate women. J Athl Enhanc. 2016; 5(5):1-4 doi:10.4172/2324-9080.1000240
27. Bagheri MR, Banaifar A, Arshadi S, Sohayli S. The effect of intense aerobic training on ICAM-1, VCAM-1 and RAGE expression in heart tissue in type 2 diabetes obese rats. Med J Mashhad Univ Med Sci 2020; 63(4): 2529-40
28. Linares-Segovia B, Guízar-Mendoza J, Amador-Licona N, Barbosa-Sabanero G, Malacara J. Effect of an exercise program, on hemodynamic, metabolic and inflammatory markers in obese Mexican adolescents. Endocrinol Metab Synd S 2013; 2: 2161-1017 doi:10.4172/2161-1017.S2-003
29. Tenório TR, Balagopal PB, Andersen LB, Ritti-Dias RM, Hill JO, Lofrano-Prado MC, et al. Effect of low-versus high-intensity exercise training on biomarkers of inflammation and endothelial dysfunction in adolescents with obesity: A 6-month randomized exercise intervention study. Pediatr Exerc Sci. 2018; 30 (1):96-105 doi:10.1123/pes.2017-0067 PMid:28787243
30. Strömberg A, Rullman E, Jansson E, Gustafsson T. Exercise-induced upregulation of endothelial adhesion molecules in human skeletal muscle and number of circulating cells with remodeling properties. J Appl Physiol 2017;122(5):1145-54 doi:10.1152/japplphysiol.00956.2016 PMid:28183821
31. Zuo X, Gu Y, Wang C, Zhang J, Zhang J, Wang G, et al. A systematic review of the anti-inflammatory and immunomodulatory properties of 16 essential oils of herbs. Evid Based Complement Alternat Med 2020;2020 doi:10.1155/2020/8878927 PMid:33354224 PMCid:PMC7735857
32. Shen CY, Jiang JG, Zhu W, Ou-Yang Q. Anti-inflammatory effect of essential oil from Citrus aurantium L. var. amara Engl. J Agricultural Food Chem 2017;65(39):8586-94 doi:10.1021/acs.jafc.7b02586 PMid:28906110
33. KH S, Tharwat SA, Abdel Megeid AA. Potential Effect of Sour Orange Peel (Citrus Aurantium) Supplementation on Lipid Profile and Liver Function of Albino Rats Fed on High Fat Diet. Egyptian J Nutr 2019;34(3):93-111. doi:10.21608/enj.2019.144749
34. Osfor M, Hegazy A, El-Moaty M, Elmadbouly MA, Afify R, Elbahnasawy AS. Hypo-cholesterolemic and hypoglycemic effects of orange albedo powder (Citrus aurantium L.) on male albino rats. Int J Nutr Food Sci 2013;2(2):70-6 doi:10.11648/j.ijnfs.20130202.17
35. Li J, Luo Y, Zhan L, Gu Y, Zhang W, Wen Q, et al. Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering. J Pharmaceutical Biomedical Analysis 2022;211: 114621. doi:10.1016/j.jpba.2022.114621 PMid:35123328
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rabiei Dargah N, Keshavarz S, Hosseini S A, Zahedi H. Impact of endurance training and Citrus aurantium L.var. amara Engl. (CAVAO) consumption on lipid profile, intercellular adhesion molecules-1 (ICAM-1) and vascular cell adhesion molecules-1 (VCAM-1) in aged Sprague-Dawley rats. Feyz Med Sci J 2023; 27 (6) :619-628
URL: http://feyz.kaums.ac.ir/article-1-4878-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 27, Issue 6 (Bimonthly 2023) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.06 seconds with 46 queries by YEKTAWEB 4660