:: Volume 26, Issue 4 (Bimonthly 2022) ::
Feyz 2022, 26(4): 424-434 Back to browse issues page
Association between adiponectin gene single nucleotide polymorphisms with age of diabetes onset and initiating insulin therapy in patients with type 2 diabetes
Elaheh Mamashli , Farnaz Seifi-Skishahr , Marefat Siahkouhian , Manouchehr IranparvarAlamdari , Asadollah Asadi , Behzad Davarnia
Department of Medical Genetics and Pathology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, I.R. Iran. , b.davarnia@gmail.com
Abstract:   (919 Views)
Background: The incidence of type 2 diabetes is growing at an early age. Genetic factors probably play an important role in the early onset of type 2 diabetes. The present study aimed to effect of single nucleotide polymorphisms of adiponectin gene rs2241766 (+45 T/G), rs1501299 (+276 G/T) and rs17300539 (-11391G/A) on the age of diabetes onset and initiating insulin therapy in patients with type 2 diabetes.
Materials and Methods: In this case-control study, 183 patients with type 2 diabetes and 155 healthy individuals participated. Demographic and anthropometric data were collected. Genotyping was performed by using amplification refractory mutation system-PCR (ARMS-PCR). Data were analyzed by using SPSS software (version 26).
Results: According to results, in rs2241766 (SNP+45 T/G), the age of onset of diabetes and age of starting insulin therapy in the TG genotype carriers was significantly less than in TT genotype carriers (Respectively P=0.035, P=0.048). In SNP+45 T/G, 48.6% of patients with diabetes onset age<35 years were carrying the TG genotype (P=0.013). TG genotype (OR=2.381, 95% CI:1.430–7.994, P=0.006) was associated with the significantly increased risk of diabetes onset age <35 years.
Conclusion: According to the results of the present study, SNP+45 T/G of the adiponectin gene has a significant effect on the early onset of T2DM as well as the rapid progression of the disease. Evaluation of effective genetic variants can be useful in pre-diabetes screening for early detection and prevention.
Keywords: Adiponectin, Single nucleotide polymorphism, Age of diabetes onset, Age of initiating insulin therapy
Full-Text [PDF 391 kb]   (513 Downloads)    
Type of Study: Applicable | Subject: medicine, paraclinic
Received: 2022/03/28 | Revised: 2022/10/19 | Accepted: 2022/07/17 | Published: 2022/09/26
References
1. Organization WH. Global report on diabetes: executive summary. World Health Organization; 2016.
2. González EM, Johansson S, Wallander M-A, Rodríguez LG. Trends in the prevalence and incidence of diabetes in the UK: 1996–2005. J Epidemiol Community Health 2009; 63(4): 332-6.
3. Wilmot E, Idris I. Early onset type 2 diabetes: risk factors, clinical impact and management. Ther Adv Chronic Dis 2014; 5(6): 234-44.
4. Dabelea D, DeGroat J, Sorrelman C, Glass M, Percy CA, Avery C, et al. Diabetes in Navajo youth: prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care 2009; 32(Supplement_2): S141-S7.
5. Sharp PS, Brown B, Qureshi A. Age at diagnosis of diabetes in a secondary care population: 1992—2005. Br J Diabetes Vasc Dis 2008; 8(2): 92-5.
6. Feltbower R, McKinney P, Campbell F, Stephenson C, Bodansky H. Type 2 and other forms of diabetes in 0–30 year olds: a hospital based study in Leeds, UK. Arch Dis Child 2003; 88(8): 676-9.
7. Harron KL, Feltbower RG, McKinney PA, Bodansky HJ, Campbell FM, Parslow RC. Rising rates of all types of diabetes in south Asian and non-south Asian children and young people aged 0–29 years in West Yorkshire, UK, 1991–2006. Diabetes Care 2011; 34(3): 652-4.
8. Song S, Hardisty C. Early onset type 2 diabetes mellitus: a harbinger for complications in later years—clinical observation from a secondary care cohort. Int J Med 2009; 102(11): 799-806.
9. Piko P, Werissa NA, Fiatal S, Sandor J, Adany R. Impact of genetic factors on the age of onset for type 2 diabetes mellitus in addition to the conventional risk factors. J Pers Med 2020; 11(1): 6.
10. Mao X, Hong JY, Dong LQ. The adiponectin signaling pathway as a novel pharmacological target. Mini Rev Med Chem 2006; 6(12): 1331-40.
11. Hossain MM, Murali MR, Kamarul T. Genetically modified mesenchymal stem/stromal cells transfected with adiponectin gene can stably secrete adiponectin. Life Sci 2017; 182: 50-6.
12. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270(45): 26746-9.
13. [13] Howlader M, Sultana MI, Akter F, Hossain MM. Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review. Heliyon 2021; 7(8): e07851.
14. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002; 51(2): 536-40.
15. González-Sánchez JL, Martínez-Calatrava MaJ, Martinez-Larrad MT, Zabena C, Fernandez-Perez C, Laakso M, et al. Interaction of the− 308G/A promoter polymorphism of the tumor necrosis factor-α gene with single-nucleotide polymorphism 45 of the adiponectin gene: effect on serum adiponectin concentrations in a Spanish population. Clin Chem 2006; 52(1): 97-103.
16. Biswas D, Vettriselvi V, Choudhury J, Jothimalar R. Adiponectin gene polymorphism and its association with type 2 diabetes mellitus. Indian J Clin Biochem 2011; 26(2): 172-7.
17. Medicine ACoS. ACSM's health-related physical fitness assessment manual. 4nd ed. China: Lippincott Williams & Wilkins; 2013 Jan: 10-73.
18. Miller SA DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988; 16(3): 1215.
19. Hussain M, Khan HN, Awan FR. Development and application of low-cost T-ARMS-PCR assay for AGT and CYP11B1 gene polymorphisms. Mol Biol Rep 2019; 46(1): 443-9.
20. Zhang Z, Li Y, Yang X, Wang L, Xu L, Zhang Q. Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese. Gene 2018; 658: 10-7.
21. Takhshid MA, Haem Z, Aboualizadeh F. The association of circulating adiponectin and+ 45 T/G polymorphism of adiponectin gene with gestational diabetes mellitus in Iranian population. J Diabetes Metab Disord 2015; 14(1): 1-7.
22. Alimi M, Goodarzi MT, Nekoei M. Association of ADIPOQ rs266729 and rs1501299 gene polymorphisms and circulating adiponectin level with the risk of type 2 diabetes in a population of Iran: a case-control study. J Diabetes Metab Disord 2021; 20(1): 87-93.
23. Haines L, Wan KC, Lynn R, Barrett TG, Shield JP. Rising incidence of type 2 diabetes in children in the UK. Diabetes Care 2007; 30(5): 1097-101.
24. Shield J, Lynn R, Wan K, Haines L, Barrett T. Management and 1 year outcome for UK children with type 2 diabetes. Arch Dis Child 2009; 94(3): 206-9.
25. Bacha F, Lee S, Gungor N, Arslanian SA. From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation. Diabetes Care 2010; 33(10): 2225-31.
26. Gungor N, Arslanian S. Progressive beta cell failure in type 2 diabetes mellitus of youth. J Pediatr 2004; 144(5): 656-9.

XML   Persian Abstract   Print

Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 26, Issue 4 (Bimonthly 2022) Back to browse issues page