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:: Volume 26, Issue 1 (Bimonthly 2022) ::
Feyz 2022, 26(1): 30-37 Back to browse issues page
The effect of eight weeks of high intensity interval training on Let-7a, NO and VEGF levels in cardiac tissue of young rats with type 2 diabetes
Maryam Bagherinia , Bahram Abedi , Hosein Fatolahi
Department of Exercise Physiology, Mahallat Branch, Islamic Azad University, Mahallat, I.R. Iran. , maryambagheri14@yahoo.com
Abstract:   (1121 Views)
Background: Diabetes interferes with some of the factors that contribute to cardiac angiogenesis. So, this study aimed to investigate the effect of eight weeks of high-intensity interval training (HIIT) on VEGF, NO and Let-7a in young rats with type 2 diabetes.
Materials and Methods: The present study is an experimental study in which the statistical population consisted of young rats (8 weeks) with type 2 diabetes. A total of 24 young rats (8 weeks old) were divided into three groups: diabetic + HIIT, healthy + HIIT + healthy control. ELISA was used to measure VEGF and NO and Real time PCR was used for Le7-a.
Results: Diabetes + HIIT group had more VEGF compared to healthy control group (P= 0.005) and healthy + HIIT group had more VEGF than healthy control group (P=0.001). The healthy + HIIT group also had higher VEGF than the diabetes + HIIT group (P=0.005). The diabetes + HIIT group had more NO than the healthy control group (P=0.041) and the healthy + HIIT group had more NO compared to the healthy control group (P=0.005). Also, the difference between the healthy + healthy group in comparison with the diabetes + healthy group was not significant in terms of NO (P=0.07). The diabetic + healthy group had more Let-7a than the healthy control group (P=0.009) and the healthy + HIIT group had more Let-7a than the healthy control group (P=0.001). Also, the healthy + HIIT group had a higher Let-7a value compared to the diabetes + HIIT group (P=0.001).
Conclusion: The findings of this study showed that HIIT increases VEGF, Let-7a and NO in diabetic and healthy rats. However, the increase in these variables was higher in healthy samples than in diabetic samples.
Keywords: Type 2 diabetes, High-intensity interval training, Angiogenesis
Full-Text [PDF 334 kb]   (520 Downloads)    
Type of Study: Research | Subject: General
Received: 2021/07/24 | Revised: 2022/04/6 | Accepted: 2021/12/28 | Published: 2022/04/4
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Bagherinia M, Abedi B, Fatolahi H. The effect of eight weeks of high intensity interval training on Let-7a, NO and VEGF levels in cardiac tissue of young rats with type 2 diabetes. Feyz 2022; 26 (1) :30-37
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Volume 26, Issue 1 (Bimonthly 2022) Back to browse issues page
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