[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 24, Issue 5 (Bimonthly 2020) ::
Feyz 2020, 24(5): 565-575 Back to browse issues page
Interactive effect of eight weeks combined training and curcumin consumption on serum levels of interleukin-12 and some anthropometric indicators in obese sedentary woman
Motahare Mirmahzoon , Abass Salehikia , Omid Mohammaddoost *
Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, I.R. Iran. , omid.mohammaddoust800@gmail.com
Abstract:   (893 Views)
Background: Activity has turned away from the human body by machine life and has replaced with obesity. This study aimed to investigate the interactive effect of eight weeks combined training and curcumin consumption on serum levels of interleukin-12 and some anthropometric indicators in obese sedentary woman.
Materials and Methods: Semi-experimental study, Forty-eight obese women with an age range of 20-30 years were purposefully selected and divided into four groups of 12 people: control, curcumin, exercise and exercise+curcumin and for eight weeks to do combination exercises (aerobic exercise with an intensity of 60 to 80% of the MHR and resistance training with an intensity of 55 to 75% of a maximum repetition) and daily intake of curcumin of 80 mg. Fasting blood samples were taken before and after the last training session and interleukin-12 levels were measured by ELISA using kits. Data were analyzed using dependent t-test and one-way analysis of variance and significance level less than 0.05 in SPSS-22.
Result: There was a significant difference in levels of interleukin-12 and body mass index between the groups of exercise, exercise+curcumin and curcumin consumption compared to the pretest (p<0.05 intragroup). The difference between pre- and post-test group differences on levels of interleukin-12 and body mass index was significantly different between the research groups (p<0.05 between groups).
Conclusion: Eight weeks of combined training and curcumin consumption had a significant change in levels of IL-12. Physical activity causes weight loss and thus a decrease in body mass index, but the consumption of curcumin alone does not change the anthropometric indicators of individuals.
Keywords: Circuit-based exercise, Curcumin, Interleukin-12, Health status indicators, Obese sedentary women
Full-Text [PDF 713 kb]   (251 Downloads)    
Type of Study: Research | Subject: General
Received: 2020/04/23 | Accepted: 2020/09/29 | Published: 2020/12/15
References
1. Nammi S, Koka S, Chinnala KM, Boini KM. Obesity: an overview on its current perspectives and treatment options. J Nutr 2004; 3(1): 3-10.
2. Ehsani M, Kouchechian H, Kashker S. Investigation and analysis of deterrents and the level of women's participation in recreational sports activities in Tehran. J Sports Sci 2007; 5(17): 63-87.
3. Ghroubi S, Elleuch H, Chikh T, Kaffel N, Abid M, Elleuch M. Physical training combined with dietary measures in the treatment of adult obesity. A comparison of two protocols. Ann Phys Rehabil Med 2009; 52(5): 394-413.
4. Fenning A, Voss A, Nabiollahi F, Reaburn P. The reduction of oxidative stress and inflammation in obese, Type II diabetic patients following resistance training. Heart Lung Circ 2008; (17): 239-44.
5. Fatouros I, Tournis S, Leontsini D, Jamurtas A, Sxina M, Thomakos P, et al. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol 2005; 90(11): 5970-7.
6. Tartibian B, Parseh R, Baghaei B. Interleukin-6, the causative agent of necrosis of alpha and cortisol, has been shown to be highly active in women athletes. RJMS 2015; 22(133): 1-7.
7. Herbold NH, Visconti BK, Frates S, Bandini L. Traditional and nontraditional supplement use by collegiate female varsity athletes. Int J Sport Nutr Exerc Metab 2004; 14(5): 586-93.
8. Phadke AS. A review on lipid lowering activities of Ayurvedic and other herbs. Nat Prod Radiance 2007; 6(1): 81-9.
9. Cerny D, Lekic N, Vanova K, Muchova L, Horinek A, Kmonickova E, et al. Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system. Fitoterapia 2011; 82(5): 786-91.
10. Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006; 71(10): 1397-421.
11. Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V. Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. J Altern Complement Med 2009; 15(8): 891-7.
12. Singh R, Chandra R, Bose M, Luthra PM. Antibacterial activity of Curcuma longa rhizome extract on pathogenic bacteria. Curr Sci 2002; 10(2): 737-40.
13. Zhang DW, Fu M, Gao SH, Liu JL. Curcumin and diabetes: a systematic review. Evid Based Complementary Altern Med 2013.
14. Meng B, Li J, Cao H. Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications. Curr Pharm Des 2013; 19(11): 2101-13.
15. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta 2010; 411(11): 785-93.
16. Association NIRS. The value of recreational sports in higher education: Human Kinetics Publishers 2004.
17. Abdavi F, Iskander-Nejad M, Fakhri F. Confusing factors hindering women's participation in leisure and recreational sports activities. National Conference on Sports and Recreation of Tehran Municipality 2011. [in Persian]
18. Patel A. The role of inflammation in depression. Psychiatr Danub 2013; 25(2): 216-23.
19. Delavar A. Statistical methods in psychology and educational science. Tehran, Payame Noor University Press 1998. [in Persian]
20. Haghighi A, Ravasi A, Gaini A, Aminian-Razavi T, Hamedinia M. Effect of resistance training on cytokines associated with inflammation and insulin resistance in obese men. Olympic Mag 2006; 14(2): 19-29. [in Persian]
21. Smith LL. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress. MSSE 2000; 32(2): 317-24.
22. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. J Med 2000; 342(12): 836-43.
23. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000; 101(15): 1767-72.
24. Guenova E, Volz T, Sauer K, Kaesler S, Müller MR, Wölbing F, et al. IL‐4‐mediated fine tuning of IL‐12p70 production by human DC. J Immunol Res 2008; 38(11): 3138-49.
25. Sharma R, Gescher A, Steward W. Curcumin: the story so far. Eur J Cancer 2005; 41(13): 1955-68.
26. Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, et al. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol 2008; 76(11): 1590-611.
27. Preedy VR, Watson RR, Zibadi S. Dietary Components and Immune Function: Humana 2010.
28. Peake J, Wilson G, Hordern M, Suzuki K, Yamaya K, Nosaka K, et al. Changes in neutrophil surface receptor expression, degranulation, and respiratory burst activity after moderate-and high-intensity exercise. J Appl Physiol 2004; 97(2): 612-8.
29. Aggarwal BB, Kumar A, Aggarwal MS, Shishodia S. Curcumin derived from turmeric (Curcuma longa): a spice for all seasons. ATCC 2005; 23(4): 351-87.
30. Gleeson M. Immune function in sport and exercise. Elsevier Health Sciences 2006.
31. Nieman DC, Pedersen BK. Nutrition and exercise immunology: CRC Press 2000.
32. Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol 2003; 42(5): 861-8.
33. Nicklas BJ, Ambrosius W, Messier SP, Miller GD, Penninx BW, Loeser RF, et al. Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial. J Clin Nutr 2004; 79(4): 544-51.
34. Bruunsgaard H, Bjerregaard E, Schroll M, Pedersen BK. Muscle strength after resistance training is inversely correlated with baseline levels of soluble tumor necrosis factor receptors in the oldest old. JAGS 2004; 52(2): 237-41.
35. Pedersen BK, Steensberg A, Schjerling P. Muscle‐derived interleukin‐6: possible biological effects. J Physiol 2001; 536(2): 329-37.
36. Mackinnon LT. Advances in exercise immunology: J Hum Kinet 1999.
37. Shariatzadeh Junidi M, Moghaddam Z, Maleki L, Keshavarz A, Hedayati M. Short-term effect of two types of high-intensity intermittent exercise on plasma levels of TNF-α, IL-6, CRP, and lipid profile of overweight women. J S Biol Sci 2017; 9(2): 195-207. [in Persian]
38. Mosaferi-Ziaaedini M, Ebrahin K, Amani D, Arabnarmi Z. Effect of supplementary consumption of coenzyme Q10 on TNF-α serum levels during maximal training. JAUMS 2012; 12(3): 303-11. [in Persian]
39. Lim CL, Byrne C, Chew SA, Mackinnon LT. Leukocyte subset responses during exercise under heat stress with carbohydrate or water intake. Aviat Space Envir MD 2005; 76(8): 726-32.
40. Rosendal L, Sogaard K, Kjaer M, Sjogaard G, Langberg H, Kristiansen J. Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise. J Appl Physiol 2005; 98(2): 477-81.
41. Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 2003; 3(9): 745-52.
42. Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM. Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile. J Surg Res 2000; 89(2): 169-75.
43. Salimi Avanser M. Evaluation of the effect of eight weeks of intermittent exercise and consumption of curcumin on the levels of the neurotransmitter alpha alpha-neurotrophic factor derived from the brain in men with metabolic syndrome. JAUMS 2017; 17(2): 1-7. [in Persian]
44. Baravati S, Mogharnasi M, Badiakhar H, Rahimi E. Response and compatibility of plasma levels of Nesfatin-1, glucose and insulin resistance index to circuit resistance training in obese disabled men. IIOAB J 2016; 7(8): 74-81. [in Persian]
45. Nayebifar S, Afzalpour ME, Kazemi T, Eivary SHA, Mogharnasi M. The effect of a 10-week high-intensity interval training and ginger consumption on inflammatory indices contributing to atherosclerosis in overweight women. JRMS 2016; 9(6): 21-8. [in Persian]
46. Beigi F, Bijeh N, Ghahremani moghaddam M. Effect of eight weeks of concurrent tarining on the levels of some cardiovascular factors in inactive women with type II diabetes. J Diabetes Nurs 2018; 6(3): 596-83. [in Persian]
47. Tanaka H, Monahan KD, Seals DR. Age-predicted maximal heart rate revisited. J Am Coll Cardiol 2001; 37(1): 153-6.
48. Karvonen J, Vuorimaa T. Heart rate and exercise intensity during sports activities. Sports Med 1988; 5(5): 303-11.
49. Brzycki M. A practical approach to strength training: Masters Press Grand Rapids, MI 1989.
50. Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Metz-Schimmerl S, Pacini G, et al. The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Archives of Phys Med Rehabil 2005; 86(8): 1527-33.
51. Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, et al. Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study. Am J Hypertens 2012; 25(6): 651-6.
52. Tsai JL, Priya TJ, Hu KY, Yan HY, Shen ST, Song YL. Grouper interleukin-12, linked by an ancient disulfide-bond architecture, exhibits cytokine and chemokine activities. Fish Shellfish Immunol 2014; 36(1): 27-37.
53. Su W, Ito T, Oyama T, Kitagawa T, Yamori T, Fujiwara H, et al. The direct effect of IL-12 on tumor cells: IL-12 acts directly on tumor cells to activate NF-κB and enhance IFN-γ-mediated STAT1 phosphorylation. Biochem Biophys Res Commun 2001; 280(2): 503-12.
54. Hosseini Zadeh A. The effect of an endurance training course on tissue interleukin 12 (IL-12) levels and tissue tumor volume of mice with breast cancer: Islamic Azad University - Islamic Azad University, Central Tehran Branch-Faculty of Physical Education and Sports Sciences 2013. [in Persian]
55. Kang B, Song Y, Kim KM, Choe YK, Hwang S, Kim TS. Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin‐12 production in macrophages. Br J Pharmacol 1999; 128(2): 380-4.
56. Taghavi K, Farnia P, Anousheh S, Bayat M, Kazempour M, Masjidi M. Comparison of serum levels of α-TNF, interleukin-10, interleukin-12 and interferon gamma in diseases caused by Mycobacterium tuberculosis and non-tuberculosis. Shahid Sadoughi Univ Med Sci 2010; 18(4): 355-60. [in Persian]
57. Feresht F. Effect of garlic extract on interleukin-12 and interleukin-10 levels of leishmaniasis-infected macrophages. Qom Univ Med Sci J 2011; 5(1): 83-90. [in Persian].
58. Ehsan-Bakhshian D, Sheikh-Shahrokhi d. Investigation of serum levels of interleukin 12 in patients with latent hepatitis B infection in Chaharmahal and Bakhtiari province. The First International Congress and The 13th Iranian Genetic Congress 2014. [in Persian]
59. Payande A, Momenpour R, Alipour A, Yari Kh, Payende M. Determining the effect of simultaneous exercise on the response of inflammatory agents in postmenopausal women with breast cancer. First National Conference on Sports Science with the Approach of Engineering Technical Sciences: Ministry of Science, Research and Technology - Isfahan University of Technology 2018. [in Persian].
60. Rhind SG, Castellani JW, Brenner IK, Shephard RJ, Zamecnik J, Montain SJ, et al. Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure. J Physiol Regul 2001; 281(1): 66-75.
61. Andersson J, Jansson JH, Hellsten G, Nilsson TK, Hallmans G, Boman K. Effects of heavy endurance physical exercise on inflammatory markers in non-athletes. Atherosclerosis 2010; 209(2): 601-5.
62. Germanou EI, Chatzinikolaou A, Malliou P, Beneka A, Jamurtas AZ, Bikos C, et al. Oxidative stress and inflammatory responses following an acute bout of isokinetic exercise in obese women with knee osteoarthritis. Knee 2013; 20(6): 581-90.
63. Jaydari F, Johari H, Taati M, Asadian P, Alirezaei M, Sheikhzadeh F. The effects of fruit extract on catalase activity and lipid peroxidation in the heart and erythrocytes of rats following chronic ethanol consumption. J Vet Res 2011; 3(2): 179-83. [in Persian]
64. Chandra D, Gupta S. Anti-inflammatory and anti-arthritic activity of volatile oil of Curcuma longa (Haldi). Eur J Med Res 1972; 60(1): 138-43.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mirmahzoon M, Salehikia A, Mohammaddoost O. Interactive effect of eight weeks combined training and curcumin consumption on serum levels of interleukin-12 and some anthropometric indicators in obese sedentary woman. Feyz. 2020; 24 (5) :565-575
URL: http://feyz.kaums.ac.ir/article-1-4119-en.html


Volume 24, Issue 5 (Bimonthly 2020) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4319