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:: Volume 24, Issue 5 (Bimonthly 2020) ::
Feyz 2020, 24(5): 473-480 Back to browse issues page
Investigating the effects of Crocin on pituitary-adrenal axis and thyroid hormones in streptozotocin-induced diabetic male rats
Raheleh Rahbarian * , Ghazal Ataei
Department of Biology, Faculty of Science, Payame Noor University of Tehran, Tehran, I.R. Iran. , ra_rahbarian@yahoo.com
Abstract:   (609 Views)
Background: Due to the antioxidant effects of saffron in improving diabetes, this study was conducted in order to investigate the effects of crocin on pituitary-adrenal axis and thyroid hormones in diabetic rats.
Materials and Methods: In this experimental study, which was performed at Payame Noor University, 28 male rats were divided into 4 groups: control, untreatment diabetic, 2 crocin (50, 100 mg/ml, 25 days intraperitoneal injection)-treated diabetic groups. The diabetic groups obtained with intraperitoneal injection of streptozotocin. Blood sampled from the heart of the rats 25 days after the start of the experimental. Then, pituitary-adrenal axis hormones (cortisol, aldosterone, adrenocorticotropin, and thyroid hormones (TSH, T3, and T4)) were evaluated. The results were analyzed by Kruskal Wallis and LSD tests.
Results: Crocin at concentrations of 50 and 100 mg/ml has led to a significant increase in cortisol, aldosterone, and adrenocorticotropin compared to the diabetic rats. Diabetes causes a significant decrease in the levels of thyroid hormones (TSH, T3, and T4). Prescribing crocin at concentrations of 50 and 100 mg/ml has significantly increased the level of thyroid hormones compared to the untreatment diabetic group (P<0.05). Comparing the two concentrations of crocin, the group treated with the concentration of 100 mg/ml has showed a significant increase in the studied indices compared to the group treated with 50 mg/ml of crocin. Also, crosin significantly reduced the level of glucose in diabetic rats.
Conclusion: Crocin can increase the level of pituitary-adrenal and thyroid hormones in diabetic male rats.

Keywords: Diabetes mellitus, Crocin, Pituitary gland, Adrenal gland, Thyroid hormones, Rat
Full-Text [PDF 1040 kb]   (154 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2020/04/19 | Accepted: 2020/10/26 | Published: 2020/12/15
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Rahbarian R, Ataei G. Investigating the effects of Crocin on pituitary-adrenal axis and thyroid hormones in streptozotocin-induced diabetic male rats. Feyz. 2020; 24 (5) :473-480
URL: http://feyz.kaums.ac.ir/article-1-4116-en.html

Volume 24, Issue 5 (Bimonthly 2020) Back to browse issues page
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