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:: Volume 23, Issue 5 (Bimonthly 2019) ::
Feyz 2019, 23(5): 495-502 Back to browse issues page
Effect of aerobic exercise on some factors of cardiac apoptosis in male rats
Aghil Sadighi , Ahmad Abdi , Mohammad Ali Azarbayjani , Alireza Barari
Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, I.R. Iran. , a.abdi58@gmail.com
Abstract:   (3232 Views)
Background: Cardiac apoptosisplays an important role in myocardial diseases. Current evidence suggests that exercise training may modify some apoptosis-related signaling in myocardium. This study aimedto investigate the effect of aerobic training on cardiac Bax, Bcl2 and caspase-3 inmale rats.
Materials and Methods: In this experimental study, Sixteen Wistar male rats 10 weeks old with 299.74±19.32 g weight were randomly classified into control and training groups. Training groups have performed an aerobic running program (at 10-18 m/min, 10-40 min/day, and 5 days/week) on a motor-driven treadmill for six weeks.Forty eight hours after the last training session, rats were sacrificed; hearts were excised and immediately frozen in liquid nitrogen and stored at -80 °C.Bax, Bcl2 and caspase3 protein expression were evaluated by ELISA and western blot. Data were analyzed using Independent t-test and ANCOVA at P<0.05.
Result: The results showed that six weeks aerobic training significantly decreased heart Bax in rats (P=0.045). Also heart Bcl2 (P=0.003) and caspase-3 (P=0.040) were significantly increased in comparison to the training group.
Conclusion: Moderate-intensity aerobic exercise seems to modify some factors affecting the apoptosis of the heart tissue of male rats.
Keywords: Exercise training, Cardiac disease, Caspase3, Bax, Bcl2
Full-Text [PDF 290 kb]   (2234 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/01/15 | Revised: 2019/12/15 | Accepted: 2019/09/3 | Published: 2019/12/16
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Sadighi A, Abdi A, Azarbayjani M A, Barari A. Effect of aerobic exercise on some factors of cardiac apoptosis in male rats. Feyz 2019; 23 (5) :495-502
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Volume 23, Issue 5 (Bimonthly 2019) Back to browse issues page
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