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:: Volume 23, Issue 5 (Bimonthly 2019) ::
Feyz 2019, 23(5): 455-466 Back to browse issues page
Effect of hydro-alcoholic extract of pumpkin seeds on estrogen hormone and liver markers in adult female rats
Samaneh Motamed-Jahromi * , Sadegh Niami-Jahromi
Medical Faculty of Jahrom University of Medical Sciences and Bandar Abbas Educational Development Center, Bandar Abbas Medical University, Bandar Abbas, I.R. Iran. , sanammorsal400500@yahoo.com
Abstract:   (2408 Views)
Background: Alternative synthetic estrogen replacement hormone therapy has a deleterious effect on the liver tissue. It seems the pumpkin seeds can be a good alternative to hormone therapy. In this regard, this study aimed to investigate the effect of hydro-alcoholic extract of pumpkin seeds on the amount of estrogen hormone in adult female rats and its effects on liver markers And liver and ovarian tissue changes.
Materials and Methods: In this experimental study, 40 immature female wistar rats (in the weight range of 10±180 g and the age of 60 days) were divided into 5 groups of 8 animals: three experimental groups, control and sham groups. The hydro-alcoholic extract of pumpkin seeds was injected intraperitoneally for 21 consecutive days to the experimental groups (doses: 20, 50 and 100 mg/kg body weight). Serum levels of hepatic and ovarian markers were determined and histological studies were performed on the liver and ovary.
Results: Significant decrease in ALP and significant increase in FSH and LH and the graph follicles in experimental group 3 and a significant reduction in the number of primary and primary follicles in the three experimental groups compared to the group Controlling and the number of secondary follicles in the experimental group 1 were observed compared to the experimental groups 2 and 3 (P>0.05).
Conclusion: Estrogen in the hydro-alkali extract of pumpkin seeds without harmful effects on the liver tissue can lead to ovulation and is an appropriate alternative to artificial estrogens and regulating the gastrointestinal tract.
Keywords: Estrogen, Liver, Rats, Female, Extract
Full-Text [PDF 535 kb]   (2116 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/09/24 | Accepted: 2019/08/17 | Published: 2019/12/16
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Motamed-Jahromi S, Niami-Jahromi S. Effect of hydro-alcoholic extract of pumpkin seeds on estrogen hormone and liver markers in adult female rats. Feyz 2019; 23 (5) :455-466
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