:: Volume 23, Issue 3 (Bimonthly 2019) ::
Feyz 2019, 23(3): 216-222 Back to browse issues page
The effect of zinc chloride on the passive avoidance memory of female rats ovariectomized in the pre-pubertal stage
Pooran Ghahramani , Hooman Eshagh Harooni , Seyed Raza Fatemi Tabatabaei , Ahmad Ali Moazedi
Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran. , p.ghahramani1393@gmail.com
Abstract:   (2548 Views)
Background: Many studies have shown that zinc has an important effect on learning, memory and cognition. On the other hand, ovariectomy in adult female rats reduces memory and learning. Also, regarding the contradictory reports on the effects of zinc chloride on memory and learning, this study aimed to examine the effect of zinc chloride on passive avoidance memory of ovariectomized female rats in the pre-pubertal stage.
Materials and Methods: In this experiment, fifty female rats were ovariectomized at postnatal day 21-22 and were divided into six groups; control, sham (saline), ovariectomized (saline) and the ovariectomized groups received zinc chloride 5, 10 and 20 mg/kg at puberty. Then on postnatal day 77, passive avoidance memory was examined by the shuttle box. Different doses of zinc chloride were administered 30 min before training and the test took place 24 hours later.
Results: Ovariectomy decreased the stopping time in the dark room compared with the sham group, non-significantly. Groups received zinc chloride 5 mg/kg showed a significant increase in stopping time in the dark room compared to the ovariectomized group received saline (P<0.01).
Conclusion: The findings of this study show that pre-pubertal ovariectomy has no effect on passive avoidance memory and injection of zinc chloride can be reduced memory and learning.
Keywords: Pre-pubertal ovariectomy, Zinc chloride, Shuttle box, Passive avoidance
Full-Text [PDF 229 kb]   (970 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2018/05/15 | Revised: 2019/08/17 | Accepted: 2019/05/18 | Published: 2019/07/31
References
1. Assunção M, Santos-Marques MJ, Carvalho F, Andrade JP. Green tea averts age-dependent decline of hippocampal signaling systems related to antioxidant defenses and survival. Fre Rad Biol Med 2010; 48(6): 831-8.‌
2. Maret W, Sandstead H. Zinc requirements and the risks and benefits of zinc supplementation. J Trac Elemen Med Biol 2006; 20(1): 3-18.
3. Takeda A. Movement of zinc and its functional significance in the brain. Brain Res Rev 2000; 34(3): 137-48.‌
4. Piechal A, Blecharz-Klin K, Pyrzanowska J, Widy-Tyszkiewicz E. Maternal zinc supplementation improves spatial memory in rat pups. Biol Trac Elemen Res 2012; 147(1-3): 299-308.
5. Gower‐Winter SD, Levenson CW. Zinc in the central nervous system: from molecules to behavior. Biofactors 2012; 38(3): 186-93.
6. Palizvan M, Mosleh M. Effect of sumatriptan on the field potentials of the CA1 region of hippocampus in male rats. AMUJ 2013; 15(69): 77-84.
7. Gould E, Woolley CS, Frankfurt M, McEwen BS. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci 1990; 10(4): 1286-91.‌
8. Sun AY, Wang Q, Simonyi A, Sun GY. Botanical phenolics and brain health. Neuromolecul Med 2008; 10: 259-74.
9. Talebi A, Naghdi N, Sepehri H, Rezayof A. The Role of Estrogen Receptors on Spatial Learning and Memory in CA1 Region of Adult Male Rat Hippocampus. Iranian J Pharmaceut Res 2010; 9(2): 183-91.
10. Goldin M, Segal M, Avignone E. Functional plasticity trigger formation and pruning of dendritic spines in culured hippocampal networks. J Neurosci 2001; 21(1): 186-93.‌
11. Woolley CS. Estrogen-mediated structural and functional synaptic plasticity in the female rat hippocampus. Horm Behav 1998; 34(2): 140-48.‌
12. Sunar F, Baltaci AK, Ergene N, Mogulkoc R. Zinc deficiency and supplementation in ovariectomized rats: their effect on serum estrogen and progesterone levels and their relation to calcium and phosphorus. Pakistan J Pharmaceut Sci 2009; 22(2): 150-4.
13. Valizadah Z, Moazedi AA, Parham GH. The role of NMDA receptor the hippocampus (CA1) in the absence or presence of zinc chloride on learning and memory in adult male rats. J Physiol Pharmacol 2009; 12 (3): 245-53.
14. Phirozy S, Khosh Sokhan Mozaphar M. effect of hydro-alcholic extract of stachys lavandulifolia on Passive avoidance learning in gonadectomized male rats. Novel Findings in Bioscience Agriculture 2015 May 31, Zabol, Iran.
15. Roshanaei K, Rezazadeh Amin SA, Heidarieh N. Effects of Valeriana officinalis extract on passive avoidance learning in Wistar rats gonadectomized. First National Conference on Medicinal Plants and Sustainable Agriculture, 2013 Oct 18, Hamedan, Iran.
16. Moazedi AA, Ghotbeddin Z, Parham GH. Comparison of the effects of dose-dependent zinc chloride on short term and long-term memory in adult male rats. Pakistan J Biol Sci 2007; 10(16): 2704-8.‌
17. Lashgari R, Motamedi F, Zahedi Asl S, Shahidi S, Komaki A, Behavioral and electrophysiological studies of chronic oral administration of L-type calcium channel blocker verapamil on learning and memory in rats. Behav Brain Res 2006; 171(2): 324-8.‌
18. Moazedi AA, Ghotbedin Z, Parham GH. The effect of Zncl2 on passive avoidance and motor activity learing due to administration of Alcl3 in male rats. J Physiol Pharmacol 2008; 146-152.
19. Shahidi S, Motamedi F, Bakeshloo SA, Taleghani BK. The effect of reversible inactivation of the supramammillary nucleus on passive avoidance learning in rats. Behav Brain Res 2004; 152(1): 81-7.‌
20. Shojaei A, Shabani M, Pilevarian A, Parsania Sh, Razavinasab M. Effect of acute administration of Cisplatin on memory, motor learning, balance and explorative behaviours in rats. J Physiol Pharmacol 2012; 16 (2): 121-35.
21. Levinoff EL, Chertkow H.The biological and cognitive effects of estrogen on the aging brain. Drug Aging 2002; 5: 41-4.
22. Ghahramani P, Harooni HE, Fatemi Tabatabaei SR, Moazedi AA. Effects of zinc chloride on passive avoidance memory of male rats, in gonadectomized peri-pubertaly. Urmia Med J 2018: 28(11): 708-14.
23. Cole TB, Martyanova A, Palmiter RD. Removing zinc from synaptic vesicles does not impair spatial learning, memory, or sensorimotor functions in the mouse. Brain Res 2001; 891(1): 253-65.‌
24. Flinn JM, Hunter D, Linkous DH, Lanzirotti A, Smith LN, Brightwell J, Jones BF. Enhanced zinc consumption causes memory deficits and increased brain levels of zinc. J Physiol Behav 2005; 83(5): 793-803.‌
25. Hamadani JD, Fuchs GJ, Osendarp SJ, Huda SN, Grantham McGregor SM. Zinc supplementation during pregnancy and effects on mental development and behavior of infants: a follow-up study. Lancet 2002; 360(9329): 290–4.
26. Turner TY, Soliman MR. Effects of zinc on spatial reference memory and brain dopamine (D1) receptor binding kinetics in rats. Prog Neuropsychopharmacol Biol Psychiatry 2000; 24(7): 1203–17.
27. Mocchegiani E, Bertoni-Freddari C, Marcellini F, Malavolta M. Brain, aging and neurodegeneration: role of zinc ion availability. Prog Neurobiol 2005; 75(6): 367-90.
28. Nakashima AS, Dyck RH. Zinc Cortical Plasticity Brain Res Rev 2009; 59(2): 347-73.‌


XML   Persian Abstract   Print



Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 23, Issue 3 (Bimonthly 2019) Back to browse issues page