History and Objectives: Since the fungus Kumbuja contains various useful chemicals and the significant of treatment of open wounds and for evaluation of the effect of this fungus, this study was conducted in laboratory of anatomy of Shaheed Beheshti Unv. Med. Sci. in 1998.

Materials and Methods: The experimental strategy of this study was carried out on 70 male adult rats in two groups, i.e. control and experimental groups. Then, each group was divided into 3 sub-groups according to duration of study (4, 7 and 15 days). The experimental group received the fungus Kumbuja for a period of 30 days and control group received tap water. Then, a wound was created in the skin. At the end of study, two samples of skin were taken. After histological processing, number of fibroblasts, macrophages and neutrophils were counted. In addition, tensile strength of the tissue was calculated. Student’s t-test was used for statistical analysis.

Results: Number of fibroblasts in control and experimental groups were 88±10.9 and 103.6±13.5 respectively. The increase of fibroblasts at 4th day (P<0.05), the decrease of neutrophils (P<0.01) and the increase of tensile strength (P<0.05) at 7th day was significant.

Conclusion and Recommendations: It is concluded that consumption of this fungus can accelerate healing of open wound in rats and it is recommended to conduct more studies for isolation of its effective chemicals and its applicability in human beings.