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:: Volume 21, Issue 2 (Bimonthly 2017) ::
Feyz 2017, 21(2): 157-161 Back to browse issues page
Serum copper and iron levels in idiopathic tinnitus
Hamid Reza Abtahi , Farank Yazdkhasti
Department of E.N.T, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran. , fayaz.fy@gmail.com
Abstract:   (4814 Views)

Background: Tinnitus is a multi-factorial disorder. Many oxidative pathologies in different loci of auditory pathway can cause it. In this regard oxidative processes result in an imbalance in the trace elements in ear incorporated into the structure of enzymes responsible for antioxidant protection. Therefore, the present study is aimed to compare the concentration of iron (Fe) and cupper (Cu) as the trace elements in the serum of patients with tinnitus and the healthy subjects.

Materials and Methods: This cross-sectional study was conducted on patients with idiopathic tinnitus (n=55) and the healthy volunteers (n=47) referred to the ENT clinic of   Alzahra hospital (Isfahan, Iran) during 2014-2015. Among the healthy participants 47 age- and sex-matched cases were selected based on convenient sampling. The concentration of Fe and Cu were measured by flame atomic absorption spectroscopy.

Results: There was a significant decrease in mean serum Cu level in patients with tinnitus (112.48±27.59) compared to the control group (139.52±14.24), (P<0.001). Moreover there were no statistically significant differences between the mean serum Fe in patients with tinnitus (95.68±35.97) and control group (103.95±53/68), (P=0.38).

Conclusion: In the present study, a relationship was seen between the serum Cu level and the occurrence of tinnitus. Given the notion that trace elements are among the antioxidant micronutrients, defining such a cause-and-effect relationship between trace elements and tinnitus may shed some light on the treatment of the disease, which requires more studies.

Keywords: Tinnitus, Copper, Iron
Full-Text [PDF 160 kb]   (2560 Downloads)    
Type of Study: Research | Subject: General
Received: 2017/05/27 | Revised: 2017/07/17 | Accepted: 2017/05/27 | Published: 2017/05/27
References
1. Kalcioglu MT, Bayindir T, Erdem T, Ozturan O. Objective evaluation of the effects of intravenous Lidocain on innitus. Hear Res 2005; 199(1-2): 81-8.
2. Jastreboff PJ, Gray WC, Mattox DE. Tinnitus and hyperacusis. In: Cummings CW, editor. Otolaryngology head and necksurgery. 3rd ed. St Louis: Mosby; 1998. p. 3198–222.
3. Meyerhoff WL, Cooper JC. Tinnitus. In: Paparella MM, editor. Otolaryngology. 3rd ed. London: WB Saunders; 1991. p. 1169–79.
4. Yetiser S, Tosun F, Satar B, Arsalan M, Akcam T, Ozkaptan Y. The role of zinc in management of tinnitus . Auris Nasus Larynx 2002; 29(4): 329-33.
5. Henderson D, Bielefeld EC, Harris KC, Hu BH.The role of oxidative stress in noise-induced hearing loss. Ear Hear 2006; 27(1): 1-19.
6. Knight JA. Free radicals: their history and current status in aging and disease. Ann Clin Lab Sci 1998; 28(6): 331-46.
7. Attias J, Reshef I, Shemesh Z, Salomon G. Support for the central theory of tinnitus generation: a military epidemiological study. Int J Audiol 2002; 41(5): 301-7.
8. Neri S, Signorelli S, Pulvirenti D, Mauceri B, Cilio D, Bordonaro F, et al. Oxidative stress, nitric oxide, endothelial dysfunction and tinnitus. Free Radic Res 2006; 40(6): 615-8.
9. Hoekstra WG, Suttie JW, Ganther HG, Mentz W. Trace Elements Metabolism in Animals. Baltimore: University Park Press; 1974. p. 61. Vol 2.
10. Theophanides T, Anastassopoulou J. Copper and carcinogenesis. Crit Rev Oncol Hematol 2002; 42(1): 57-64.
11. Prutki M, Poljak-Blazi M, Mihaljevic B, Orescanin V, Zarkovic N. Uptake of anti-anemic substance ferric-sorbitol-citrate by normal and malignant cells and its effects on expression of transferrin receptor 1 and ferritin. Cancer Biother Radiopharm 2006; 21(6): 636-44.
12. Turi JL, Yang F, Garrick MD, Piantadosi CA, Ghio AJ. The iron cycle and oxidative stress in the lung. Free Radic Biol Med 2004; 36(7): 850-7.
13. Ghio AJ, Kennedy TP, Whorton AR, Crumbliss AL, Hatch GE, Hoidal JR. Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates. Am J Physiol 1992; 263(5 Pt 1): L511-8.
14. Prohaska JR, Hoffman RG. Auditory startle response is diminished in rats after recovery from perinatal copper deficiency. J Nutr 1996; 126(3): 618e27.
15. Huppke P, Brendel C, Kalscheuer V, Korenke GC, Marquardt I, Freisinger P, et al. Mutations in SLC33A1 cause a lethal autosomal-recessive disorder with congenital cataracts, hearing loss, and low serum copper and ceruloplasmin. Am J Hum Genet 2012; 90(1): 61e8.
16. Horvath R, Freisinger P, Rubio R, Merl T, Bax R, Mayr JA, et al. Congenital cataract, muscular hypotonia, developmental delay and sensorineural hearing loss associated with a defect in copper metabolism. J Inherit Metab Dis 2005; 28(4): 479e92.
17. McFadden SL, Ding D, Salvi R. Anatomical, metabolic and genetic aspects of age-related hearing loss in mice. Audiology 2001; 40(6): 313e21.
18. Scheffler IE. Mitochondria. John Wiley & Sons, Inc., New York, NY; 1999. p. 235–8.
19. Staecker H, Zheng QY, Van De Water TR. Oxidative stress in aging in the C57B16/J mouse cochlea. Acta Otolaryngol 2001; 121(6): 666–72.
20. Salvi RJ, Ding D, Wang J, Jiang HY. 2000. A review of the effects of selective inner hair cell lesions on distortion product otoacoustic emissions, cochlear function and auditory evoked potentials. Noise Health 2, 9–26.
21. Owen Jr CA. Copper deficiency and toxicity. 1 ed. Park Ridge, N.J: Noyes Publications; 1981.
22. Toyokuni S. Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med 1996; 20(4): 553-66.
23. Weinberg ED. Roles of iron in neoplasia. Promotion, prevention, and therapy. Biol Trace Elem Res 1992; 34(2): 123-40.
24. Sha SH. Schacht J. Formation of reactive oxygen species following bioactivation of gentamicin. Free Radic Biol Med 1999; 26(3-4): 341–7.
25. Lesniak W, Pecoraro VL, Schacht J. Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species. Chem Res Toxicol 2005; 18(2): 357–64.
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Abtahi H R, Yazdkhasti F. Serum copper and iron levels in idiopathic tinnitus . Feyz 2017; 21 (2) :157-161
URL: http://feyz.kaums.ac.ir/article-1-3355-en.html


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Volume 21, Issue 2 (Bimonthly 2017) Back to browse issues page
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