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:: Volume 22, Issue 1 (Bimonthly 2018) ::
Feyz 2018, 22(1): 25-30 Back to browse issues page
The effect of Syrian mesquite (Prosopis farcta) seed extract on thioacetamide-induced oxidative stress in rats
Maryam Mohammad Pour Zehab , Fariborz Shariati-Sharifi , Abbas Jamshidian , Mohammad Reza Hajinezhad
Department of Pathobiology, Faculty of Veterinary, University of Zabol, Zabol, I. R. Iran. , hajinezhad@gmail.com
Abstract:   (19597 Views)
Background: This experimental study aimed at investigating the effect of Prosopis farcta seeds hydro-alcoholic extract on thioacetamide-induced oxidative stress in rats.
Materials and Methods: In this study, 30 adult male rats were randomly divided into three groups: healthy control, positive control, and P. farcta- treated group received thioacetamide. The healthy control rats received normal saline orally. The positive control rats received thioacetamide (50 mg/kg IP) for three times at one-day interval (oxidative stress induction). The P. farcta seed extract (100 mg/kg) was administered orally for 21 days. At the end of the experiment, blood samples were taken from the rats' heart to separate serum and the serum catalase (CAT) and superoxide dismutase (SOD) activities were determined. After euthanasia, liver and kidney were separated to determine malondialdehyde (MDA) levels.
Results: The activities of CAT and SOD were significantly lower in the thioacetamide- intoxicated group compared to those in the healthy control group (P<0.001). The treatment with P. farcta seed extract significantly increased the activities of these enzymes compared to the positive control group (P<0.001). Moreover, after three weeks of oral treatment, the P. farcta seed extract significantly reduced the liver MDA concentrations compared with the positive control rats (P<0.05).
Conclusion: It can be concluded that P. farcta seed hydro-alcoholic extract can protect against thioacetamide-induced oxidative stress.
Keywords: Thioacetamide, Liver, Prosopis farcta, Rats
Full-Text [PDF 170 kb]   (1037 Downloads)    
Type of Study: Applicable | Subject: General
Received: 2017/05/20 | Revised: 2018/03/14 | Accepted: 2018/01/3 | Published: 2018/02/24
References
1. Ishizaka Y, Yamakado M, Toda A, Tani M, Ishizaka N. Relationship between serum uric acid and serum oxidative stress markers in the Japanese general population. Nephron Clin Pract 2014; 128(1-2): 49-56.
2. Milanlioglu AP, Çilingir AP, Aydın MN. Serum antioxidant enzymes activities and oxidative stress levels in patients with acute ischemic stroke: influence on neurological status and outcome. Wiener Klinische Wochenschrift 2016; 128(5-6): 169-74.
3. Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 2014; 59(2): 713-23.
4. Bessone F. Drug induced liver injury and various complications: 22 case reports. Reactions 2016; 1594: 68-26.
5. Niki E. Biomarkers of lipid peroxidation in clinical material. Biochim Biophysic Acta 2014; 1840(2): 809-17.
6. Iqubal A, Iqubal MK, Haque SE. Experimental hepatotoxicity inducing agents: A Review. Int J Clin Pharmacol Res 2016; 30; 6(11): 325-35.
7. Totah RA, Rettie AE. Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevance. Clin Pharmacol Ther 2005 77(5): 341-52.
8. Khoubnasabjafari M, Ansarin K, Jouyban A. Critical review of malondialdehyde analysis in biological samples. Curr Pharm Anal 2016; 12(1): 4-17.
9. Persia FA, Rinaldini E, Hapon MB, Gamarra-Luques C. Overview of Genus Prosopis Toxicity Reports and its Beneficial Biomedical Properties. J Clin Toxicol 2016; 6(326): 2161-0495.
10. Zargar S. Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi J Biological Sci 2014; 21(2): 139-45.
11. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95(2): 351–8.
12. Saidi MR, Farzaei MH, Miraghaee S, Babaei A, Mohammadi B, Bahrami MT, Bahrami G. Antihyperlipidemic Effect of Syrian Mesquite (Prosopis farcta) Root in High Cholesterol Diet–Fed Rabbits. J Evid Based Complementary Altern Med 2016; 21(4): NP62-6.
13. Indo HP, Yen HC, Nakanishi I, Matsumoto KI, Tamura M, Nagano Y, et al. A mitochondrial superoxide theory for oxidative stress diseases and aging. J Clin Biochem Nutr 2015; 56(1): 1-7.
14. Sharma N, Garg V, Paul A. Antihyperglycemic, antihyperlipidemic and antioxidative potential of Prosopis cineraria bark. Indian J Clin Biochem 2010; 25(2): 193-200.
15. Afanas'ev IB, Dcrozhko AI, Brodskii AV, Kostyuk VA, Potapovitch AI. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem Pharmacol 1989; 38(11): 1763-9.
16. Zhuang Y, Liu P, Wang L, Luo J, Zhang C, Guo X, et al. Mitochondrial oxidative stress-induced hepatocyte apoptosis reflects increased molybdenum intake in caprine. Biol Trac Elem Res 2016; 170(1): 106-14.
17. Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. ‎Free Radic Biol Med 1996; 20(7): 933-56.
18. Lajnef HB, Mejri H, Feriani A, Khemiri S, Saadaoui E, Nasri N, et al. Prosopis farcta Seeds: Potential Source of Protein and Unsaturated Fatty Acids?. J Am Oil Chem Soc 2015; 92(7): 1043-50.
19. Hajinezhad M, Esmaeel Zadeh Bahabadi S, Miri H, Davari I, Darvish Sargazi M. Effect of Hydroalcoholic Extract of Prosopis farcta Pod on Liver Histopathology and Malondialdehyde Level in Streptozotocin Diabetic Rats. Horizon Med Sci 2015; 21(1): 31-6. [in Persian]
20. Hajinezhad M, Davari S, EsmaeelZadeh S, Miri H, Akbari M, KamaliJavan S. Protective effect of hydro alcoholic extract from prosopisfarcta leaves on lipid peroxidation of serum and liver tissue in diabetic rats. JNKUMS 2015; 7(2): 267-78. [in Persian]
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Mohammad Pour Zehab M, Shariati-Sharifi F, Jamshidian A, Hajinezhad M R. The effect of Syrian mesquite (Prosopis farcta) seed extract on thioacetamide-induced oxidative stress in rats. Feyz 2018; 22 (1) :25-30
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Volume 22, Issue 1 (Bimonthly 2018) Back to browse issues page
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