Background: Asthma is a prevalent chronic pulmonary disease presented in 20% of population. Steroids have been shown to be effective in asthma treatment however, controversies are arisen in the route of administration. The present study was conducted in a private clinic in Kashan to determine the effects of different routes of corticosteroid administration (Oral, injection and inhalation) on asthma attack.

Materials and Methods: 120 patients had entered this clinical trial. Patients were distributed in three groups oral, injection and inhalation group. All subjects received salbutamol. Spirometry was performed before and after the therapy and then results were analyzed.

Results: The study population included 63 males (52%) and 57 females (48%) with the mean age of 39.9 years. Comparison of FEF25-75, FEV1 and FVC results showed non-significant differences between the oral and injection groups, however, they were more effective than inhalation corticosteroids.

Conclusion: Administration of corticosteroids either orally or by injection can be easily used to control asthma attack. Inhalation therapy is less effective and is not recommended.