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:: Volume 21, Issue 5 (Bimonthly 2017) ::
Feyz 2017, 21(5): 398-406 Back to browse issues page
The effect of essential oil of Achillea wilhelmsii flowers on cisplatin-induced hepatotoxicity
Sahar Ghanbari , Leila Amjad , Kahin Shahanipur
Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, I. R. Iran. , amjad.leila@gmail.com
Abstract:   (21419 Views)
Background: The essential oil of Achillea wilhelmsii has‎ anti-inflammatory and antioxidant properties. Cisplatin is one of the most important anticancer drugs that are widely used to treat various types of cancers. This study aimed at examining the effects of the essential oil of A. wilhelmsii flowers on cisplatin-induced hepatotoxicity in rats.
Materials and Methods: In this study, 36 male Wistar rats weighing 200-250 g were  divided  into 6 groups: 1) control, 2) cisplatin (0.4 mg/kg), 3) cisplatin and essential oil (30 mg/kg), 4) cisplatin and essential oil (60 mg/kg), 5) essential oil (30 mg/kg) and 6) essential oil (60 mg/kg).The injection was performed in the groups every day for 8 weeks. Then, serum levels of liver enzymes were measured and the liver tissue was removed for histopathological studies.
Results: The results showed no significant changes in the albumin level (P>0.05). However, the activities of hepatic factors ALT, AST, ALP and bilirubin were decreased significantly in the groups received essential oil 30 and 60 mg/kg + cisplatin and in groups only received the essential oil 30 and 60 mg/kg compared to the cisplatin group (P<0.05). Histopathological analysis of liver showed a significant difference in all groups compared to the control group, which this difference in the group received essential oil 60 mg/kg + cisplatin was higher than other groups.           
Conclusion: The essential oil of A. wilhelmsii decreases serum levels of liver factors and bilirubin against cisplatin.
Keywords: Achillea wilhelmsii, Essential oil, Cisplatin, Liver
Full-Text [PDF 276 kb]   (2555 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/12/23 | Revised: 2017/12/10 | Accepted: 2017/08/28 | Published: 2017/11/13
References
1. Mohajeri D, Doustar Y. The protective effect of alcoholic extract of saffron against liver toxicity of cisplatin in rat. Med Sci J Islamic Azad Univer Tehran Med Bran 2011; 21(4): 251-61. [in Persian]
2. Farooqui Z, Afsar M, Rizwan S, Ahmed Khan A, Khan F. Oral administration of Nigella sativa oil ameliorates the effect of cisplatin on membrane enzymes, carbohydrate metabolism and oxidative damage in rat liver. Toxicol Rep 2016; 3: 328–35.
3. Izadi Z, Sorooshzadeh A, Modarres Sanavi SA, Esna-Ashari M, Davoodi P. Investigation on antimicrobial effects of essential oil of purple coneflower (Echinacea purpurea L.) and identification of its chemical compounds. Iranian South Med J 2014; 17(1): 58-69. [in Persian]
4. Amjad L, Anther Developmental Stages, Microsporogenesis, Allergy-forming Properties and Anti-allergy Plant Achillea wilhelmsii [Dissertation]. Tehran. Islamic Azad University, Science and Research. 2008.
5. [5] Asgary S, Naderi GH, Sarrafzadegan N, Mohammadifard N, Mostafavi S, Vakili R. AntIhypertensive and Antihyperlipidemic effect of Achillea wilhelmsii. Drugs Exp Clin Res 2000; 26(3): 89-93.
6. [6] Niazmand S, Erfanian Ahmadpour M, Hajzade M, Khoshnood E. The effects of aqueous-ethanol extract of Achillea wilhelmsii on gastric acid secretion at basal, vagotomized and vagal-stimulated conditions. Feyz 2008; 12(3): 12-6. [in Persian]
7. Sharififar F, Pournourmohammadi S, Arabnejad M. Immunomodulatory actirity of aqueous extract of Achillea wilhelmsii C. Koch in mice. Indian J Exp Biol 2009; 47(8): 668-71.
8. Azadbakht M, Morteza-Semnani K, Khansari N. The essential oils composition of Achillea wilhelmsii C. Koch leaves and flowers. J Med Plan 2003; 2(6): 55-8. [in Persian]
9. Amjad L, Majd A, Fallahian F, Saadatmand S. Comparative study of allergenicity of mature and immature pollen grains of Achillea wilhelmsii. Arak Univ Med Sci J 2008; 11(2): 1-9. [in Persian]
10. Zargari A. Medicinal plants. Tehran: Tehran University Press; 1992. [in Persian]
11. Omidbeygi R. Processing of medicinal plants. Mashhad: Behnashr; 2005. [in Persian]
12. Ghahreman A. Flore Iran. Tehran: Research Institute of Forests and Rangelands; 1989. [in Persian]
13. Pieroni A, Quave CL, Villanelli ML, Mangino P, Sabbatini G, Santini L, et al. Ethnopharmacognostic survey on the natural ingredientsused in folk cosmetics, cosmeceuticals and remedies for healing skin diseases in the inland Marches, Central-Eastern Italy. J Ethnopharmacol 2004; 91(2): 331-4.
14. Mohammadi-Sichani M, Amjad L, Mohammadi-Kamalabadi M. Antibacterial activity of methanol extract and essential oil of Achillea wilhelmsii against pathogenic bacteria. Zahedan J Res Med Sci 2011; 13(3): 9-14. [in Persian]
15. Mandour MA, Al-Shami SA, Al-Eknah MM, Hussein YA, El-Ashmawy IM. The acute and lomg-term safety evaluation of aqueous methanolic and ethanolic extracts of Achillea fragrantissima. Afr J Pharm Pharmacol 2013; 7(32): 2282-90.
16. Habibi E, Shokrzadeh M, Chabra A, Naghshvar F, Keshavarz-Maleki R, Ahmadi A. Protective effects of Origanum vulgare ethanol extract against cyclophosphamide-induced liver toxicity in mice. Pharm Biol 2015; 53(1): 10–15.
17. Moshtaghi AA. Clinical Biochemistry blood and urine. Tehran: Chahar; 1990. [in Persian]
18. Aragon G, Younossi ZM. When and how to evaluated mildly elevated liver enzymes in apparently healthy patients. Clevel Clin J Med 2010; 77(3): 195-204.
19. Mohajeri D, Doustar Y, Mousavi G. Protective and antioxidant activities of turnip root ethanolic extract against cisplatin induced hepatotoxicity in rats. Zahedan J Res Med Sci 2012; 13(9): 8-15. [in Persian]
20. Yousef MI, Saad AA, El-Shennawy LK. Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats. Food Chem Toxicol 2009; 47(6): 1176-83.
21. El-Banna H, Soliman M, Al-wabel N. Hepatoprotective effects of Thymus and Salvia essential oil on paracetamol- induced toxicity in rats. J Phy Pharm Adv 2013; 3(2): 41-7.
22. Maheswari R, Manohari S. Syzygium cumini (L.) seeds extract ameliorates cisplatin induced hepatotoxicity in male wistar rats. Int J Pharm Sci Res 2015; 6(2): 444-50.
23. Joydeep P, Nasiruddin M, Ali Khan R, Saydeeul HA. Protective role of Nigella sativa oil in isoniazid induced hepatotoxicity in rats. Eur J Pharm Med Res 2016; 3(10): 307-312.
24. Shahraki MR, Miri Moghadam E, Palan MJ, Mirshekari H, Shahraki E. The survey of Teucrium Polium toxicity effect on liver and serum lipoproteins in normoglycemic male rats. Zahedan J Res Med Sci 2006; 8(3): 227-32.
25. Gilani AH, Janbaz KH. Protective effect of Artemisia scoparia extract against acetaminophen-induced hepatotoxicity. General Pharmacol Vascular System 1993; 24(6): 1455-1458.
26. Kalantari H, Galehdari H, Zaree Z, Gesztelyi R, Varga B, Haines D, et al. Toxicological and mutagenic analysis of Artemisia dracunculus extract. Food Chem Toxicol 2013; 51: 26-32.
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Ghanbari S, Amjad L, Shahanipur K. The effect of essential oil of Achillea wilhelmsii flowers on cisplatin-induced hepatotoxicity. Feyz 2017; 21 (5) :398-406
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Volume 21, Issue 5 (Bimonthly 2017) Back to browse issues page
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