[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 22, Issue 3 (Bimonthly 2018) ::
Feyz 2018, 22(3): 267-273 Back to browse issues page
The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats
Saied Kamal Sadat-Hoseini , Valiollah Dabidi Roshan
Department of Exercise Physiology, Faculty of Physical Education, University of Mazandaran, Babolsar, I. R. Iran. , vdabidiroshan@yahoo.com
Abstract:   (3215 Views)
Background: In the last decade, cancer incidence increases progressively with age and older patients cannot participate in treatment programs due to the special physical condition and side effects of anti-tumor drugs. Therefore, the aim of this study was to examine the effect of six-week voluntary wheel running exercise on doxorubicin (DOX)-induced hepatotoxicity in aging model rats.
Materials and Methods: Thirty-two Wistar male rats were randomly assigned to exercise and control groups with 4 subgroups. All subjects received a daily injection of D-galactose for nine weeks (100 mg/kg/day, intraperitoneally). The training protocol included six weeks of voluntary wheel running exercise. Doxorubicin was administrated intraperitoneally (1mg/kg/day) for 15 days. Superoxide dismutase (SOD) and apoptosis-inducing factor (AIF) levels were measured after liver tissue homogenization by enzyme-linked immunosorbent assay (ELISA) method.
Results: Administration of cumulative dose of DOX caused no significant decrease in SOD and AIF levels (P=0.797, and P=0.869, respectively). Six weeks of voluntary wheel running exercise led to insignificant decrease in SOD and insignificant increase in AIF in comparison to the  control group (P=0.377, and P=0.948, respectively).
Conclusion: According to the results of the present study, the six-week voluntary wheel running exercise has no significant effect on DOX-induced hepatotoxicity in aging model rats.
Keywords: Voluntary exercise, Doxorubicin, Hepatic toxicity, Oxidative stress, Apoptosis
Full-Text [PDF 254 kb]   (1264 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/10/31 | Revised: 2018/08/5 | Accepted: 2018/06/17 | Published: 2018/08/4
References
1. Marques-Aleixo I, Santos-Alves E, Mariani D, Rizo-Roca D, Padrão AI, Rocha-Rodrigues S, et al. Physical exercise prior and during treatment reduces sub-chronic doxorubicin-induced mitocho‌ndrial toxicity and oxidative stress. Mitochondrion 2015; 20: 22-33.
2. Sadat-Hoseini SK, Dabidi Roshan V, Shojaei Shahrokhababdi M. Effects of time courses of treadmill training in tissue toxicity induced by Different doses of doxorubicin in multiple organs. RJMS 2017; 23 (151): 31-42. [in Persian]
3. Sakr S.A, Mahran H. A, Lamfon H.A. Protective effect of ginger (Zingiber officinale) on Adriamycin - induced hepatotoxicity in albino rats. J Med Plant Res 2011; 5(1): 133-40.
4. Zolfagharzadeh F, Dabidi Roshan VD. Pre‌treat‌ment Hepatoprotective Effect of Regular Aerobic Training against Hepatic Toxicity Induced by Doxorubicin in Rats. Asian Pacifi J Cancer Prev 2013; 14(5): 2931-6.
5. Katsuhito N, Shuhei F, Ayano O, Hiroki K. Protective effects of taurine on doxorubicin-induced acute hepatotoxicity through suppression of oxi‌dative stress and apoptotic responses. Anti-Cancer Drugs 2016; 27(1): 17-23.
6. Alishahi A, Dabidi-Roshan V, Hedayati M. Pretreatment Effects of Regular Aerobic Training on the IGF System and Hepatotoxicity Induced by Doxorubicin in Rats. Asian Pac J Cancer Prev 2013; 14 (12): 7427-31.
7. Jamali N, Dabidi Roshan V, Sadat-Hoseini SK. Hepatic damage and oxidative Stress induced by acute administration various dosages of Doxo‌rubicin: Pretreatment Effect of six weeks regular aerobic exercise. Urmia Med J 2016; 27(4): 310-20. [in Persian]
8. Sadat-Hoseini SK, Dabidi Roshan V. The Interactive Effects of two forced and voluntary exercise training method and Nanocurcumin sup‌plement on Doxorubicin-induced Hepatotoxicity in aging induced by D-galactose. Tehran Univ Med J 2017; 24 (11):807-816. [In Persian]
9. Waltke LJ. An Overview of Cancer Rehabi‌litation and Exercise in the Literature: Promoting Increased Referrals to Improve Oncology Out‌comes. J Patient Cent Res Rev 2014; 1(3): 137-141.
10. Campisi J. Aging, Cellular Senescence, and Cancer. Annu Rev Physiol 2013; 75: 685-705.
11. Fu C, Wang T, Wang Y, Chen X, Jiao J, Ma F, et al. Metabonomics study of the protective effects of green tea polyphenols on aging rats induced by d-galactose. J Pharm Biomed Ana‌l 2011; 55(5): 1067-74.
12. Lee J, Cho JY, Kim WK. Anti-inflammation effect of Exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis. Nutr‌ition Res Pract 2014; 8(3): 284-91.
13. Hydock DS, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity. Exp‌ Biol Med 2012; 237(12): 1483–92.
14. Ashrafi J, Dabidi-Roshan V, Zolfagharzadeh F. Tissue toxicity Induced by Doxorubicin in rats: protective role of aerobic regular exercise. Urmia Med J 2014: 25(4): 353-62. [in Persian]
15. Sardão VA, Oliveira PJ, Holy J, Oliveira CR, Wallace KB. Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts. Cancer Chemother Pharmacol 2009; 64(4): 811-27.
16. Moreira AC, Branco AF, Sampaio SF, Cunha-Oliveira T, Martins TR, Holy J, et al. Mitochondrial apoptosis-inducing factor is involved in doxo‌rubicin-induced toxicity on H9c2 cardiomyoblasts. Biochim Biophys Acta 2014; 1842(12): 2468-78.
17. Siu P, Bodyak N, Bae S, Rigor D, Kang P.M. Doxorubicin induces caspase-independent apop‌tosis in transgenic mice overexpressing CrmA. Circulation 2006; 114: II532.
18. Ascensão A, Magalhães J, Soares JM, Ferreira R, Neuparth MJ, Marques F, et al. Moderate endu-rance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the devel¬opment of cardiac apoptosis. Am J Physiol Heart Circ Physiol 2005; 289(2): 722-31.
19. Courtney SM, Kim JH, Macias BR, Canon CN, Lawler JM. The effects of exercise on caspase-independent mitochondrial proteins in regards to age-related apoptosis. Int J Exerc Sci 2009; 2(1): 37.
20. Lien CY, Jensen BT, Hydock DS, Hayward R. Short-term exercise training attenuates acute doxo-rubicin cardiotoxicity. J Physiol Biochem 2015; 71(4): 669-78.
21. Marques-Aleixo I, Santos-Alves E, Balça MM, Moreira PI, Oliveira PJ, Magalhães J, et al. Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cell-ular quality control signaling. Mitochondrion 2016; 26: 43-57.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sadat-Hoseini S K, Dabidi Roshan V. The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats. Feyz 2018; 22 (3) :267-273
URL: http://feyz.kaums.ac.ir/article-1-3153-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 22, Issue 3 (Bimonthly 2018) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.05 seconds with 46 queries by YEKTAWEB 4645