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:: Volume 21, Issue 3 (Bimonthly 2017) ::
Feyz 2017, 21(3): 247-255 Back to browse issues page
Response of glycemic index and liver tissue damage to aerobic exercise followed by coriander seed extract in streptozotocin-induced diabetic rats
Ahmad Abdi *, Asieh Abbassi-Daloii, Iman Akbari
Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, I. R. Iran. , a.abdi58@gmail.com
Abstract:   (2840 Views)

Background: The aim of this study was to investigate the response of glycemic index and liver tissue damage to aerobic training along with coriander seed extract in Streptozotocin-induced diabetic rats.
Materials and Methods: diabetic male Wistar rats (n=40, average age: 12 weeks; weight: 130±10 g) were randomly divided into four groups: Control, Extract, Exercise and Exercise+Extract. The diabetes model in rats was induced with a single injection of Streptozotocin-(60 mg/kg) dissolved in citrate buffer (0.05 mole). The high glucose level of 250 mg/dl is defined as the diabetic criterion. The extract was administered orally (150 mg/kg/day). The exercise program was six weeks of aerobic exercise, 5 times a week with 50-55% of maximal oxygen consumption.  
Results: The application of aerobic training followed by coriander seed extract in diabetic rats had a significant effect on total serum glucose (P=0.002), AST (P=0.001), ALT (P=0.005) and ALP (P=0.033); however, it had no significant effect on insulin level (P=0.656) and insulin-resistance (P=0.458).
Conclusion: It seems that the combination of a regular aerobic exercise and coriander seed extract in diabetic rats had beneficial effects on liver tissue damage and possibly can prevent and improve liver tissue damage via the  reduction of the of some liver tissue damage markers.

Keywords: Aerobic training, Diabetes, Coriander seed extract, Glycemic index, liver tissue damage
Full-Text [PDF 320 kb]   (1450 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/09/25 | Accepted: 2017/05/11 | Published: 2017/07/30
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Abdi A, Abbassi-Daloii A, Akbari I. Response of glycemic index and liver tissue damage to aerobic exercise followed by coriander seed extract in streptozotocin-induced diabetic rats. Feyz. 2017; 21 (3) :247-255
URL: http://feyz.kaums.ac.ir/article-1-3116-en.html

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Volume 21, Issue 3 (Bimonthly 2017) Back to browse issues page
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