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:: Volume 21, Issue 3 (Bimonthly 2017) ::
Feyz 2017, 21(3): 256-264 Back to browse issues page
Effect of eight weeks of resistance exercise on new biomarkers of cardiovascular disease in obese adult males
Sirvan Atashak *, Adel Ahmadi-Zad
Department of Sport Physiology, Islamic Azad University, Mahabad Branch, Mahabad, I. R. Iran. , sirvan.atashak@gmail.com
Abstract:   (4299 Views)
Background: Obesity and its related disorders are the cause of cardiovascular disease and an increased risk of morbidity and mortality. Nevertheless, the results of studies indicated that exercise training have beneficial health effects on obesity and risk markers of cardiovascular disease. Therefore, the purpose of this study was to examine the effect of 8 weeks of resistance training on lipocalin2 (LCN2) and fatty acid binding protein (FABP) in obese adult males.
Materials and Methods: In this quasi-experimental study, the obese adult men (n=24) were randomly assigned into Control and Exercise groups. Exercise group was participated in a resistance exercise program with 50-80% of one Repeated- Maximum (IRM) intensity for 8 weeks (three times per week). Venous blood samples were collected before and after the exercise. Moreover, body composition indexes were measured at pre- and post-training programme
Results: Resistance exercise caused a significant decrease in the body fat percent, waist circumference and waist to hip ratio (WHR) in Exercise group (P<0.05). Moreover, the results indicated a significant decrease in Exercise group for LCN2 concentration after resistance training (P=0.002) compared to Control group (P=0.799). Also a significant decrease in FABP4 concentration was found in Exercise group (P=0.002).
Conclusion: The results of the present study suggest that 8 weeks of resistance exercise   improve body composition and decrease the new cardiovascular biomarkers in obese men. However, further research is necessary to understand the molecular mechanisms involved.
Keywords: Resistance training, Obesity, Cardiovascular diseases, Lipocalin-2, FABP4 protein
Full-Text [PDF 272 kb]   (1708 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/06/11 | Accepted: 2017/05/11 | Published: 2017/07/30
1. Zhang H, Tong TK, Qiu W, Zhang X, Zhou SH, Liu Y, et al. Comparable Effects of High-Intensity Interval Training and Prolonged Continuous Exercise Training on Abdominal Visceral Fat Reduction in Obese Young Women. J Diabetes Res 2017; 2017.
2. Ndumele CE, Matsushita K, Lazo M, Bello N, Blumenthal RS, Gerstenblith G, et al. Obesity and subtypes of incident cardiovascular disease. J Am Heart Assoc 2016; 5(8). pii: e003921.
3. Mann DL, Zipes DP, Libby P, Bonow RO. Braunwald's heart disease: a textbook of cardiovascular medicine: Elsevier Health Sciences; 2014.
4. Shah A, Mehta N, Reilly MP. Adipose inflammation, insulin resistance, and cardiovascular disease. JPEN J Parenter Enteral Nutr 2008; 32(6): 638-44.
5. Abella V, Scotece M, Conde J, Gómez R, Lois A, Pino J, et al. The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases. Biomarkers 2015; 20(8); 565-71.
6. Choi KM, Kim TN, Yoo HJ, Lee KW, Cho GJ, Hwang TG, et al. Effect of exercise training on A-FABP, lipocalin- 2 and RBP4 levels in obese women. Clin Endocrinol (Oxf) 2009; 70(4): 569-74.
7. Luo L, Ma X, Pan X, Xu Y, Xiong Q, Xiao Y, et al. Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men. Medicine 2016 95(30): 30. e4039.
8. Atia RRA, Abulfadle KAA. Serum Lipocalin 2 levels in acute exercised prediabetic rat model in comparison to normal healthy control. AJCEM 2015; 3(3): 105-109.
9. Wu G, Li H, Fang Q, Shan J, Lei Zh, Jing Zh, et al. Elevated circulating lipocalin-2 levels independently predict incident cardiovascular events in men in a population-based cohort. Arterioscler Thromb Vasc Biol 2014; 34: 2457-64.
10. Furuhashi M, Saitoh S, Shimamoto K, Miura S. Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases. Clinical Medi-cine Insights. Cardiology 2014; 8(Suppl 3): 23-33.
11. Hao Y, Ma X, Luo Y, Hu X, Pan X, Xiao Y, et al. Associations of Serum Adipocyte Fatty Acid Binding Protein With Body Composition and Fat Distribution in Nondiabetic Chinese Women. Clin Endocrinol Metab 2015; 100(5): 2055-062.
12. Artinian NT, Fletcher GF, Mozaffarian D, Kris-Etherton P, Van Horn L, Lichtenstein AH, et al. Interventions to promote physical activity and dietary lifestyle changes for cardiovascular risk factor reduction in adults a scientific statement from the American Heart Association. Circulation 2010; 122(4): 406-41.
13. Taghian F, Zolfaghari M, Hedayati M. Effects of Aerobic Exercise on Serum Retinol Binding Protein4, Insulin Resistance and Blood Lipids in Obese Women. Iran J Public Health 2014; 43(5): 58-665.
14. Mohammadi A, Khajehlandi A. Impact of Aerobic Exercise Training on Insulin Resistance and Plasma Lipocalin 2 levels in Obese Young Men. Biomed Pharmacol J 2014; 7(1): 47-52.
15. Nikseresht M, Rajabi H, Nikseresht A. The effects of nonlinear resistance and aerobic interval training on serum levels of apelin and insulin resistance in middle-aged obese men. Tehran Univ Med J 2015; 73(5): 375-83. [in Persian]
16. Brzycki M. Strength testing: predicting a one – rep max from repetitions-to-fatigue. J Phys Educ Recreat Dance 1993; 64(1): 88-8.
17. Jackson AS, Pollock ML. Generalized equations for predicting body density of men. Br J Nutr 1978; 40(3): 497-504.
18. Bird SP, Tarpenning KM, Marino FE. Designing resistance training programmes to enhance muscular fitness. Sports Med 2005; 35(10): 841-51.
19. Heydarpour P, Fayazi S, Haghighi Sh. Resistance Training Effect on Lipid Profile and Body Fat Percentage of Premenopausal Women. Jundishapur J Chronic Dis Care 2015; 4(2): e28339.
20. Dias I, Farinatti P, De Souza MD, Manhanini DP, Balthazar E, Dantas DL, et al. Effects of Resistance Training on Obese Adolescents. Med Sci Sports Exerc 2015; 47(12): 2636-44.
21. Tresierras MA, Balady GJ. Resistance training in the treatment of diabetes and obesity: 185 mechanisms and outcomes. J Cardiopulm Rehabil Prev 2009; 29(2): 67-75.
22. Willis LH, Slentz CA, Bateman LA, Shields T, Piner LV, Bales CW, et al. Effects of aerobic and/or resistance training on body mass and fat mass in overweight or obese adults. J Appl Physiol 2012; 113(12): 1831–7.
23. Maesta N, Nahas EA, Nahas N, Orsatti FL, Fernandes CE, Traiman P, et al. Effects of soy protein and resistance exercise on body composition and blood lipids in postmenopausal women. Maturitas 2007; 56(4): 350-8.
24. Mehrabani J, Damirchi A, Rahmaninia F. Effect of Two Aerobic Exercise Intensities on Lipocalin-2, Interleukin-1ß Levels, and Insulin Resistance Index in Sedentary Obese Men. Sport Physiology 2014; 6(21): 95-108. [in Persian]
25. Moghadasi M, Mohammadi Domieh A. Effects of Resistance versus Endurance Training on Plasma Lipocalin-2 in Young Men. Asian J Sports Med 2014; 5(2): 108-114.
26. Mohammadi Domieh A, Khajehlandi A. Lipocalin-2: Response to Resistance Training in Obese Young Men. Intl j Sport Std 2014; 4(4): 458-461.
27. Mohammadi Domiyeh A, Khajehlandi A. The effects of 8 eight weeks resistance versus endurance training on lipocalin-2 level in non-athlete male students. Armaghan-e-Danesh 2012; 17(5): 460-8. [in Persian]
28. Talebi-garakani E, Hoseini-Andargoli M, Fathi R, Safarzade AR. Changes of Adipose Tissue Lipocalin-2 gene Expression in Response to One Session Exercise in the Streptozotocin-Induced Diabetic Rats. Iran J Endocrinol Metab 2012; 14(2): 178-84. [in Persian]
29. Conde J, Otero M, Scotece M, Abella V, López V, Pino J, et al. E74-like factor 3 and nuclear factor-κB regulate lipocalin-2 expression in chondrocytes. J Physiol 2016; 594(21): 6133-46.
30. Lázaro I, Ferré R, Plana N, Aragonès G, Girona J, Merino J, et al. Lifestyle changes lower FABP4 plasma concentration in patients with cardiovascular risk. Rev Esp Cardiol 2012: 65(2): 152-7.
31. Moghadasi M, Abdollahpur N, Abdehgah E, Hosseini F, Hosseini SA. Effect of eight weeks resistance training on adipocyte fatty acid-binding protein in obese middle-aged men. Intl j Sport Std 2014; 4(10): 1198-1204.
32. Moghadasi M, Nuri R, Ahmadi N. Effects of 8 weeks high intensity aerobic exercise on serum retinol binding protein 4 levels in female athletes. Braz J Biomotricity 2013; 7(1): 37-42.
33. Safarzade A, Jafaee M, Talebi-Garakani E, Fathi R. Effects of Four Week Progressive Resistance Training on Plasma FABP4 and Lipid Profile Concentrations in Diabetic Rats Iran J Endocrinol Metab 2014; 15(6): 538-44.
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Atashak S, Ahmadi-Zad A. Effect of eight weeks of resistance exercise on new biomarkers of cardiovascular disease in obese adult males. Feyz. 2017; 21 (3) :256-264
URL: http://feyz.kaums.ac.ir/article-1-3022-en.html

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Volume 21, Issue 3 (Bimonthly 2017) Back to browse issues page
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