[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 20, Issue 1 (Bimonthly 2016) ::
Feyz 2016, 20(1): 89-95 Back to browse issues page
Iron profile in obese compared to normal children
Fatemeh Tabatabaei , Mohammadreza Sharif , Davood Kheirkhah , Mahla Madani
Isfahan Endocrine and Metabolism Research Center , madani.mahla@yahoo.com
Abstract:   (4182 Views)

Background: Obese children are not only prone to various diseases, but due to the higher-caloric and lower nutritional values of their diet are also exposed to different micronutrient deficiencies. Therefore, this study was conducted to evaluate the iron profile in obese   compared to non-obese normal cases.

Materials and Methods: This Cross-sectional study was conducted on 200 children (5-15 years) during 2013-2014 in Isfahan. The case and control groups were consisted of 100 obese and none-obese children with no underlying diseases, respectively admitted to the pediatric endocrinology clinic. For all children serum iron, ferritin and total iron-binding capacity were measured. The data were analyzed using independent t-test and chi square tests.

Results: Forty three and 24% of the children were suffering from iron deficiency in the case and control groups, respectively )P<0.004(. Among the obese children 88.4% of the obese cases with iron deficiency had a serum ferritin value of >15µg/L.

Conclusion: Due to the increasing prevalence of iron deficiency among the obese children, screening for iron deficiency seems necessary in children and adolescents with high BMI.

Keywords: Iron profile, Iron deficiency, Obese children
Full-Text [PDF 195 kb]   (3244 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2016/04/13 | Revised: 2017/08/2 | Accepted: 2016/04/13 | Published: 2016/04/13
References
1. Buchanan AO, Marquez ML. Pediatric nutrition and nutritional disorders. In: Marcdante KJ, Kliegman RM. Nelson Essentials of Pediatrics. 7th ed. Philadelphia: Elsevier Saunders; 2015. p. 86-105.
2. Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA 2010; 303(3): 242-9.
3. Gills L, Gills A. Nutrient inadequacy in obese and non obese youth. Can J Diet Pract Res 2005; 66(4): 2.
4. Li C, Ford ES, Zhao G, Mokdad AH. Prevalence of pre diabetes and it's association with clustering of cardiometabolic risk factors and hyperinsulinemia among us adolescents: NHANES 2005- 2006. Diabetes Care 2009; 32(2): 342-7.
5. Pinhas-Hamiel O, Doron-Panush N, Reichman B, Nitzan-Kaluski D, Shalitin S, Geva-Lerner L. Obese children and adolescents a risk group for low vitamin B12 concentration. Arch Pediatr Adolesc Med 2006; 160(9): 933-6.
6. Zimmermann MB, Hurrell RF. Nutritional iron deficiency. Lancet 2007; 370(9586): 511–20.
7. Panepinto JA, Punzalan CP, Scott JP. Hematology. In: Marcdante KJ, Kliegman RM. Nelson Essentials of Pediatrics. 7th ed. Philadelphia: Elsevier Saunders; 2015. p. 506-33.
8. Bahrami M. Malnutrition and it's effect on development of Iranian children. J Pediatr Dis 2004; 14: 149-56.
9. Safavi M, Sheikhoeslam R, Abdollahi Z, Naghavi M, Sadeghian S, Sadeghzadeh E. Assessment of iron status and its related factors in Iranian pregnant women 2001 spring. Iran J Epidemiol 2006; 1: 1-10.
10. Karen G, Halterman J, Kaczorowski JM, Auginar P, Weitzman M. Overweight children and adolescents: a risk group for iron deficiency anemia. Pediatrics 2004; 114: 104-8.
11. Ghaemi N, Jafarzadeh M, Bagheri S. Relationship between Obesity and Iron, Calcium and Phosphorus levels in Obese Children 2 - 16 Years Old. Med J Mashhad Univ Med Sci 2012; 55(3): 134-8.
12. Ghadiri-Anari A, Nazemian N, Vahedian-Ardakani HA. Association of Body Mass Index with Hemoglobin Concentration and Iron Parameters in Iranian Population. ISRN Hematol 2014; 2014: 525312.
13. Lefebvre P, Letois F, Sultan A, Nocca D, Mura T, Galtier F. Nutrient deficiencies in patients with obesity considering bariatric surgery: a cross-sectional study. Surg Obes Relat Dis 2014; 10(3): 540-6.
14. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, et al. 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11 2002; (246): 1-190.
15. Larner NB, Sills R. Iron- Deficiency Anemia in: Kliegman RM, Stanton BF, Geme JW, Schor NF, Behrman RE. Nelson Text Book of Pediatrics. 19th ed. Philadelphia: Elsevier Saunders; 2011. p. 1655-58.
16. Cepeda-Lopez AC, Osendarp SJ, Melse-Boon‌stra A, Aeberli I, Gonzalez-Salazar F, Feskens E, et al. Sharply higher rates of iron deficiency in obese Mexican women and children are predicted byobesity-related inflammation rather than by differences in dietary iron intake. Am J Clin Nutr 2011; 93(5): 975-83.
17. Zafon C, Lecube A, Simó R. Iron in obesity. An ancient micronutrient for a modern disease. Obes Rev 2010; 11(4): 322-8.
18. Zimmermann MB, Zeder C, Muthayya S, Winichagoon P, Chaouki N, Aeberli I, et al. Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes (Lond) 2008; 32(7): 1098–1.
19. Sonnweber T1, Ress C, Nairz M, Theurl I, Schroll A, Murphy AT, et al. High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal ironabsorption. J Nutr Biochem 2012; 23(12): 1600-8.
20. Cepeda-Lopez AC, Aeberli I, Zimmermann MB. Does obesity increase risk for iron deficiency? A review of the literature and the potential mechanisms. Int J Vitam Nutr Res 2010; 80(4-5): 263-70.
21. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Guzman G, Holterman AX, et al. Elevated systemic hepcidin and iron depletion in obese premenopausal females. Obesity (Silver Spring) 2010; 18(7): 1449–56.
22. Tussing-Humphreys LM, Nemeth E, Fantuzzi G, Freels S, Holterman AX, Galvani C, et al. Decreased serum hepcidin and improved functional iron status 6 months after restrictive bariatric surgery. Obesity (Silver Spring) 2010; 18(10): 2010–16.
23. del Giudice EM, Santoro N, Amato A, Brienza C, Calabro P, Wiegerinck ET, et al. Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency. J Clin Endocrinol Metab 2009; 94(12): 5102–7.
24. Tussing-Humphreys L, Pusatcioglu C, Nemeth E, Braunschweig C. Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, andobesity: introducing hepcidin. J Acad Nutr Diet 2012; 112(3): 391-400.
25. Aeberli I, Hurrell RF, Zimmermann MB. Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children. Int J Obes (Lond) 2009; 33(10): 1111–17.
26. Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D. Novel urine hepcidin assay by mass spectrometry. Blood 2005; 106(9): 3268-70.
27. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003; 101(7): 2461-63.
28. Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 2006; 131(3): 788-96.
29. Laftah AH, Ramesh B, Simpson RJ, Solanky N, Bahram S, Schumann K, et al. Effect of hepcidin on intestinal iron absorption in mice. Blood 2004; 103(10): 3940-44.
30. Knutson MD, Oukka M, Koss LM, Aydemir F, Wessling-Resnick M. Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 over expression and down-regulated by hepcidin. Proc Natl Acad Sci USA 2005; 102(5): 1324-28.
31. Sanad M, Osman M, Gharib A. Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: a case control study. Ital J Pediatr 2011; 37: 34.
32. Amato A, Santoro N, Calabrò P, Grandone A, Swinkels DW, Perrone L, et al. Effect of body mass index reduction on serum hepcidin levels and iron status in obese children. Int J Obes (Lond) 2010; 34(12): 1772-4.
33. Mujica-Coopman MF, Brito A, López de Romaña D, Pizarro F, Olivares M. Body mass index, iron absorption and iron status in childbearing age women. J Trace Elem Med Biol 2015; 30: 215-9.
34. Nead KG, Halterman JS, Kaczorowski JM, Auinger P, Weitzman M. Overweight children and adolescents: a risk group for iron deficiency. Pediatrics 2004; 114(1): 104-8.
35. Neymotin F, Sen U. Iron and obesity in females in the United States. Obesity (Silver Spring) 2011; 19(1): 191-9.
36. Moafi A, Rahgozar S, Ghias M, Ahar EV, Borumand A, Sabbaghi A, et al. A study on body mass index, blood pressure, and red blood cell indices in new entering students of the University of Isfahan. Int J Prev Med 2011; 2(4): 280-5.
37. Eftekhari M, Mozaffari-Khosravi H, Shidfar F. The relationship between BMI and iron status in iron-deficient adolescent Iranian girls. Public Health Nutr 2009; 12(12): 2377-81.
38. Sharma AP, McKenna AM, Lepage N, Nieuwenhuys E, Filler G. Relationships among serum iron, inflammation, and body mass index in children. Adv Pediatr 2009; 56: 135-44.
39. Moschonis G, Chrousos GP, Lionis C, Mougios V, Manios Y. Healthy Growth Study group. Association of total body and visceral fat mass with iron deficiency in preadolescents: the Healthy Growth Study. Br J Nutr 2012; 108(4): 710-9.
40. Manios Y, Moschonis G, Chrousos GP, Lionis C, Mougios V, Kantilafti M, et al. The double burden of obesity and iron deficiency on children and adolescents in Greece: the Healthy Growth Study. J Hum Nutr Diet 2013; 26(5): 470-8.
41. Gartner A, Berger J, Bour A, E Ati J, Traissac P, Landais E, et al. Assessment of iron deficiency in the context of the obesity epidemic: importance of correcting serum ferritin concentrations for inflammation. Am J Clin Nutr 2013; 98(3): 821-6.
42. Menzie CM, Yanoff LB, Denkinger BI, McHugh T, Sebring NG, Calis KA, et al. Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. J Am Diet Assoc 2008; 108(1): 145-8.
43. Yanoff LB, Menzie CM, Denkinger B, Sebring NG, McHugh T, Remaley AT, et al. Inflammation and iron deficiency in the hypoferremia of obesity. Int J Obes (Lond) 2007; 31(9): 1412-9.
44. McClung JP, Karl JP. Iron deficiency and obesity: the contribution of inflammation and diminished iron absorption. Nutr Rev 2009; 67(2): 100-4.
45. Tussing-Humphreys LM, Liang H, Nemeth E, Freels S, Braunschweig CA. Excess adiposity, inflammation, and iron-deficiency in female adolescents. J Am Diet Assoc 2009; 109(2): 297-302.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tabatabaei F, Sharif M, Kheirkhah D, Madani M. Iron profile in obese compared to normal children. Feyz 2016; 20 (1) :89-95
URL: http://feyz.kaums.ac.ir/article-1-2979-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 20, Issue 1 (Bimonthly 2016) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.06 seconds with 46 queries by YEKTAWEB 4645