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:: Volume 21, Issue 4 (Bimonthly 2017) ::
Feyz 2017, 21(4): 305-316 Back to browse issues page
The effect of aqueous extract of Avicennia marina (Forsk.) Vierh. leaves on liver enzymes' activity, oxidative stress parameters and liver histopathology in male diabetic rat
Akram Hamzevi, Seyyed Damoon Sadoughi *, Raheleh Rahbarian
Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, I. R. Iran. , damoon.sadoughi@mshdiau.ac.ir
Abstract:   (3241 Views)
Background: Avicennia marina has antioxidant and anti-diabetic properties. This study was conducted to examine the effect of aqueous extract of A. marina on liver enzymes' activity, oxidative stress parameters and liver histopathology in diabetic rats.
Materials and Methods: In this experimental study, 28 male rats were allocated into the equal groups of control, diabetic control and experimental diabetic 1 and 2. The diabetes in diabetic control and experimental diabetic groups was induced using an intraperitoneal injection of 120 mg/kg alloxan. The experimental diabetic groups received the aqueous extract of A. marina (100 and 200 mg/kg, i.p.) in alternate days for one month. Sterile distilled water was injected to the animals of control and diabetic control groups. At the end of the treatment period, serum levels of ALT, AST, GGT and ALP were measured. Then, levels of SOD, GST, CAT and MDA were measured in the liver tissue. The liver sections were prepared and examined by an optical microscope.
Results: Results showed that administration of the A. marina extract (100 and 300 mg/kg, ip) to the diabetic rats significantly decreased the serum levels of liver enzymes and tissue level of MDA. Also, the activity of the liver tissue's antioxidant enzymes was increased (P<0.05). The A. marina extract dose-dependently decreased liver damages in diabetic rats.
Conclusion: Administration of the A. marina extract improves liver tissue oxidative stress indices and decreases the serum level of liver enzymes. Also, A. marina extract improves liver tissue injuries induced by diabetes.
Keywords: Diabetes mellitus, Avicennia marina, Liver enzymes, Oxidative stress, Rats
Full-Text [PDF 469 kb]   (990 Downloads)    
Type of Study: Research | Subject: General
Received: 2016/04/7 | Accepted: 2017/07/4 | Published: 2017/10/5
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Hamzevi A, Sadoughi S D, Rahbarian R. The effect of aqueous extract of Avicennia marina (Forsk.) Vierh. leaves on liver enzymes' activity, oxidative stress parameters and liver histopathology in male diabetic rat. Feyz. 2017; 21 (4) :305-316
URL: http://feyz.kaums.ac.ir/article-1-2961-en.html

Volume 21, Issue 4 (Bimonthly 2017) Back to browse issues page
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