Anaplastic cervical cancer in a virgin girl without any known risk factor, is rare. With respect to its rarity, severity and prognosis, we introduce a case referred to Shohada hospital in Tehran, in 1378.

The case, a 31 years old virgin girl with acute urinary retention, anemia, fever and abnormal uterine bleeding was admitted. Many times, she expelled vaginally some tissues with pathologic report of highly malignant neoplasm of unknown cellular origin. Regarding clinical and paraclinical data, the patient underwent radical hysterectomy (Wertheim) and pelvic lymph node dissection. Pathologic report was highly malignant anaplastic neoplasm with massive lymphatic invasion to cervix. The operation followed by chemotherapy and radiotherapy. Five months later, the patient managed by chemoradiation, because of recurrence of tumor in para-aortic lymph nodes. Finally nine months following the first diagnosis, she expired from uremia.

In conclusion, supposing unknown risk factors for cancer of cervix, probability of this cancer in virgins should be considered. Early detection of cervical cancer in this group who are apparently without any known risk factors, is of utmost importance.