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:: Volume 16, Issue 7 (Supplement 2013) ::
Feyz 2013, 16(7): 695-696 Back to browse issues page
Apoptosis and anti-tumor activities of newly synthesized metal complexes
Fereshteh Nazari , Mohammad Shabani , Mojtaba Falahati
Islamic Azad University , sagharnazary@yahoo.com
Abstract:   (18147 Views)

Background: Since the discovery of the anti-tumor activity of cisplatin, medicinal chemists have synthesized a wide range of metal complexes and examined their potential application toward anti-tumor activity both in vitro and in vivo. Although the metal-complexes show a marvelous effect on current cancer therapy, they are hampered by various side effects, resistance phenomena and limitation in different types of cancer treatments. The current study was designed to investigate the possible anti-tumor and apoptotic activity of metal complexes containing Pt, Pd, Co, Ni.

Materials and Methods: In this study, four metal complexes containing Pt, Pd, Co, Ni were synthesized and applied on (PC12) cancer cells using different concentrations and the MTT and LDH methods were performed to determine apoptosis.

Results: The results demonstrated that Pt (IC50=4.9 µM) substituted complexes were more active than other derivatives such as Pd (IC50=6.5 µM), Ni (IC50=39.5 µM) and Cu (IC50=64.3 µM). However, all these complexes showed LDH and apoptotic activity. Moreover, LDH release was concentration-dependent 200 µM concentration of Pt, Pd, Co, Ni caused 94%, 84%, 64% and 55% LDH release, respectively.

Conclusion: The nature and position of the substituents and the bridging group on the metal ligands play crucial roles in determining the anti-cancer activities of newly synthesized complexes.

Keywords: Anti-tumour, Apoptosis, Metal complex
Full-Text [PDF 96 kb]   (1570 Downloads)    
Type of Study: Research | Subject: General
Received: 2013/03/3 | Revised: 2013/03/3 | Published: 2013/03/15
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Nazari F, Shabani M, Falahati M. Apoptosis and anti-tumor activities of newly synthesized metal complexes. Feyz 2013; 16 (7) :695-696
URL: http://feyz.kaums.ac.ir/article-1-1814-en.html


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This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
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Volume 16, Issue 7 (Supplement 2013) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
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