[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 16, Issue 1 (Bimonthly 2012) ::
Feyz 2012, 16(1): 1-8 Back to browse issues page
Effect of the adenosine A1 receptor agonist on demyelination and remyelination processes in lysolecithin induced demyelination in rat optic chiasm
Ali Akbar Asghari , Mahnaz Azarnia , Sayyed Javad Mirnajafi-Zadeh , Mohammd Javan
Tarbiat Modares University , mjavan@modares.ac.ir
Abstract:   (8458 Views)

Background: Demyelination in central nervous system is usually followed by remyelination however, chronic lesions with subsequent functional impairment result from the eventual failure of remyelination process, as seen in multiple sclerosis. Remyelination is the process through which oligodendrocyte-progenitor cells (OPCs) restore new myelin sheathes around demyelinated axons. This study aimed to investigate the effect of A1 receptor agonist, N6-cyclohexyladenosine (CHA), on the demyelination and remyelination processes in rat optic chiasm following lysophosphatidylcholine (LPC)-induced demylination.

Materials and Methods: In this experimental study, LPC was injected into the optic chiasm of three groups of rats (n=6). Control group received aCSF on different days following LPC injection. Two groups of animals received CHA on days 0-14 or 14-28 post-lesion. Demyelination and remyelination levels were evaluated by recording visual evoked potential (VEP) from the scalp.

Results: The highest level of demyelination was occurred on day 7 post-lesion LPC injection and gradually reduced during the days 7-28. The P-wave latency was significantly increased on day 7 and then partially restored during the days 7-28 post-lesion. CHA administration during the days 0-14 attenuated demyelination process. In addition, CHA administration in remyelination phase (days 14-28) was able to potentiate the endogenous myelin repair.

Conclusion: Injection of CHA could prevent the lysolecithin-induced variations in VEP. The effects of CHA may be mediated through increment of OPCs proliferation and their differentiation into myelinating oligodendrocytes.

Keywords: Demyelination, Remyelination, Multiple sclerosis, N6-Cyclohexyladenosine, Visual evoked potential, Oligodendrocyte progenitor cells, Neural stem cells, Rat
Full-Text [PDF 240 kb]   (1632 Downloads)    
Type of Study: Research | Subject: General
Received: 2012/01/8 | Revised: 2012/01/18 | Published: 2012/04/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Asghari A A, Azarnia M, Mirnajafi-Zadeh S J, Javan M. Effect of the adenosine A1 receptor agonist on demyelination and remyelination processes in lysolecithin induced demyelination in rat optic chiasm. Feyz 2012; 16 (1) :1-8
URL: http://feyz.kaums.ac.ir/article-1-1366-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 16, Issue 1 (Bimonthly 2012) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.04 seconds with 46 queries by YEKTAWEB 4645