2024-03-29T13:15:23+03:30 http://feyz.kaums.ac.ir/browse.php?mag_id=2&slc_lang=fa&sid=1
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Effect of ethylene oxide sterilization on the osteoinductivity of demineralized allograft bone powder Mahdi Ghadri Golestani Seyyed Hamidreza Aghayan aghayan_itb@yahoo.com Babak Arjmand Anusheh Kazemian Seyyed Amirhosein Tavakkoli Seyyeyed Kazem Hoseini Farrokh Tiregari Seyyed Mohammadjavad Mortazavi Abstract: Background: Ethylene oxide is widely used for secondary sterilization of bone allograft to reduce the risk of infection and associated complications. In this study the effects of ethylene oxide gas sterilization on the osteoinductivity of demineralized bone powder is investigated. Materials and Methods: Two separate implants consisting 30 mg aseptically prepared, and 30 mg ethylene oxide-sterilized demineralized bone powder was placed into two different muscle pouches created in the paravertebral muscles of eighteen rats. After 4 weeks, they were removed with 0.5 cm normal surrounding tissue. Histological examination was done to determine the presence or absence of osteoinduction. Results: All except one of eighteen aseptically prepared demineralized bone powder sites histologically contained new bone elements (94.4 %) and fourteen (77.7%) out of eighteen ethylene oxide sterilized demineralized bone powder sites showed evidence of new bone elements. There is no significant difference in osteoblast formation in the two groups (p>0.05). Conclusion: It is concluded that ethylene oxide sterilization in 42˚C did not significantly reduce the osteoinductivity of demineralized bone powder. So, it can be considered as a suitable but not perfect method for secondary sterilization of demineralized bone powder. Allograft Demineralized bone powde Ethylene oxide Osteoinduction Sterilization Transplantation 2008 1 01 1 6 http://feyz.kaums.ac.ir/article-1-2-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Isolation of rabbit bone marrow mesenchymal stem cells and differentiontion into bone, cartilage, and adipose cell lineages Mohammad reza Baghban Eslaminejad bagesla@yahoo.com Hamid Nazarian Background: By far rabbit marrow-derived mesenchymal stem cells (MSCs) have been used in several experimental cell therapies especially in reconstruction of bone and cartilage defects. While in vitro differentiation potentials of these cells have rarely been investigated, it is the subject of the present study. Materials and Methods: In this experimental study, rabbit MSCs were extracted and culture-expanded through several passages using 0.5 ml bone marrow sample aspirated from the animal’s tibia. The passaged-3 cells were then cultivated in the osteogenic, adipogenic and chondrogenic conditions for 21 days after which differentiations were evaluated by specific staining as well as RT-PCR analysis for related gene expression.Results: The culture-expanded cells appeared to be fibroblastic in morphology. In osteoinductive cultures, the cells formed nodules which were positively stained red following alizarin red staining. In adipogenic cultures, the cells developed some lipid droplets which were positively stained red with oil red. The sections prepared from the chondroinductive cultures exhibited metachromatic property with toluidine blue staining. According to RT-PCR analysis, the bone-related genes including osteocalcin, osteopontin and collagen I, the adipocyte-specific genes such as LPL, PPAR-alpha and PPAR-gamma, and also the cartilage-specific genes including aggreacan, collagen II and X were expressed in the osteogenic, adipogenic and chondrogenic cultures respectively.Conclusion: Taken together, MSCs isolated from rabbit’s bone marrow are tripotent cells with the ability to differentiate into osteocytic, adipocytic and chondrocytic cell lineages. Bone marrow Cell differentiation Cartilage Mesenchymal stem cells Adipose bone 2008 1 01 7 13 http://feyz.kaums.ac.ir/article-1-5-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 The effectiveness of acupressure on intramuscular injection pain Negin Masoudi Alavi alavi@accir.com Marzieh Ataee Mina Mohammadi Maryam Alireazei Maryam Shafiee seyed Hamzeh Abbaszadeh Background: Intra muscular (IM) injection is a painful rout for drug administration. Acupressure or Shiatsu is a method for decreasing pain and anxiety. In this clinical trial study, the effectiveness of acupressure in reduction of IM injection pain was assessed in patients referring to Emergency Center No. 1 in Kashan city.Materials and Methods: It was a single blind cross over clinical trial in which the patients with two injections of the same drug were compared. One injection was followed by application of acupressure and the other without it. The numerical visual analogue scale from 0 to 10 was used for pain measurement. Results: The average pain score was 5 without acupressure and 3 with it (p<0.001). The mean pain reduction score with acupressure was 2.5. The acupressure technique was significantly more effective in male than in female (p<0.001). Age had significant reverse relationship with pain sensation. Conclusion: It seems that acupressure can effectively reduce the pain induced by IM injections. Acupressure Intramuscular injection Pain 2008 1 01 14 18 http://feyz.kaums.ac.ir/article-1-6-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Effect of castor oil on induction of labor Farzaneh Saberi saberi_f2002@yahoo.com Masoumeh Abedzadeh Zohre Sadat Alireza Eslami Background: Considering high complications of labor induction with drugs, finding an easy, inexpensive, confident method for induction of labor is important. This study was performed to evaluate the effect of castor oil on initiation of labor in pregnancies after 40 weeks in Shabihkhani Hospital in Kashan during 2004-2006. Materials and Methods: This randomized clinical trial study was performed on 200 women after their 40 weeks of pregnancy. Women were divided to two groups (100 women in case group and 100 women in control group). The case group took 60 ml castor oil while control group didn’t take any treatment. The two groups were compared for onset of labor in 24 hours, time of onset of labor, delivery time and method and Apgar score of their newborns by X2, CI, OR and t-tests. Results: Labor was induced in 70% of women in the case group versus 12% in the control group during 24 hours (p<0.001, OR=17.11, CI=8.17-35.84) and vaginal delivery happened in 28% of women in the case and 1% of women in the control group (p<0.001. OR=29.5. CI=5.86-226.4). There was no significant difference between the two groups in the method of delivery and newborns Apgar score. Conclusion: The use of castor oil can induce labor in pregnant women after 40 weeks without any increase in the complications of pregnancy including caesarean section, and drop in Apgar score. To confirm findings, it is recommended to perform further clinical randomized studies. Castor oil Labor Induction Vaginal delivery 2008 1 01 19 23 http://feyz.kaums.ac.ir/article-1-7-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Risk factors for antibacterial resistance of isolates producing extended-epectrum β-Lactamase in Gram Negative Bacilli of hospitalized neonates in Shahid Beheshti hospital Rezvan Moniri moniri_re@yahoo.com Ziba Mosayebi Gholamabbas Mousavi  Background: The occurrence of isolates producing extended-spectrum β-lactamase (ESBL) has increased worldwide. Gram-negative bacilli producing the extended-spectrum β-lactamase (ESBL) are responsible for resistance against oxy-imino beta-lactames and monobactams, and may be considered as the major pathogens in the neonatal intensive care units (NICU). The purpose of this study was to determine the rate of beta-lactam antibiotic resistance in fecal flora of newborns and the risk factors leading to their colonization.Materials and Methods: This descriptive study was carried out on 167 hospitalized newborns in Shahid Beheshti Hospital in Kashan in 2006. The fecal isolated gram-negative bacilli were prepared using standard tests. The pattern of sensitivity to antibiotics and the ESBL production was investigated on isolates with the criteria suggested by Clinical Laboratory Standards Institutes (CLSI). Data were analyzed statistically by Fischer’s exact and Chi square tests.Results: Colonization of fecal flora with gram-negative microorganisms was determined in 120 stool samples. Klebsiella pneumonia, Escherichia coli, and microorganisms producing ESBL were identified in 53 (44.2%), 34 (28.3 %), and 35 (29.2%), respectively. 65.7% (23 out of 35) of microorganisms producing ESBL were K.pneumoniae. Risk factors for colonization of gram negative bacilli producing ESBL were birth weight ≤ 2500gr. (P<0.00008), any antibiotic usage in infants (P<0.0001), preterm neonates (P<0.00013), total parenteral feeding (P<0.0007), administration of ampicillin (P<0.0017), respiratory disease (P<0.0037), ventilator support (P7 days (P<0.0082), administration of cefotaxime (P<0.0247), and C-section delivery (P<0.048).Conclusion: To decrease the morbidity and mortality rates following the infection caused by ESBLs colonized in the intestine of infants, protection of normal non-pathogenic bacterial flora is important. This can be provided by the efficient application of infection control measures, and limitation of antibiotic usage to strict clinical indications.   Antibacterial resistance Beta-lactamase I Hospitalized neonates Gram negative bacilli 2008 1 01 24 30 http://feyz.kaums.ac.ir/article-1-8-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Correlation of serum cholinesterase and liver transaminases level changes in pesticide factory workers Hamid Reza Joshaghani hr_joshaghani@yahoo.com Alireza Ahmadi Naser Behnampour Background: There are two types of cholinesterase enzymes in human, red blood cell or true and plasma or false cholinesterases. Some chemical constituents of the pesticides such as organophosphates, and carbamates, either interfere or inhibit the cholinesterase activity. The determination of cholinesterase activity has a high application in damage to the liver by the pesticides. The employees in pesticide factories are one of the groups exposed to poisoning with the pesticides. Aim this research was study of effect of this toxins on the serum cholinesterase and transaminases levels in workers.Materials and Methods: This cohort study was carried out in 2006 on 63 employees of a pesticide factory with sampling from the subjects in days 1 and 90. Cholinesterase level was determined with butyrylthiocholine substrate and alanin and aspartate transaminase levels with kinetic techniques.Results: The mean serum cholinesterase level in phase 1 was 9569 ± 2496 IU/L, while in the second phase it was 7970 ± 2067 IU/L. This drop in cholinesterase level was statistically significant (paired t test, mean = 1599, 95%CI=1140-2058, P<0,001). Alanine transaminase increase in the second phase compared with the first one was statistically meaningful (Paired t test, mean=-7.9, 95% CI=-10.9-4.9, p<0.001). Eight subjects (12.7%) had more than 35% reduction in cholinesterase activity. Conclusion: In spite of was not correlation between reduction serum cholinesterase with increase of serum transaminases, considering reduction of cholinesterase activity in 17 (27%) of workers in a three months period it seems logical to set a program to have a routine check up of cholinesterase activity in workers engaged in such occupations. Cholinesterase Factory workers Pesticides Phosphoric acid esters Serum transaminases 2008 1 01 31 35 http://feyz.kaums.ac.ir/article-1-24-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Diabetes mellitus in patients with Herpes Zoster Mohammad Nassaji-Zavareh hnassaji@yahoo.com Ramin Taheri Raheb Ghorbani Maryam Aminian Background: Herpes Zoster (HZ) is the reactivation of latent varicella-zoster virus due to such risk factors as aging and immunosupression. Diabetes Mellitus (DM) causes immunosupression and can activate HZ. This study focuses on the relationship between Herpes Zoster and Diabetes Mellitus. Materials and Methods: In this cross-sectional study 103 patients referred to the dermatology and infectious disease clinics with HZ (cases) and 142 with other diseases (control) were enrolled to the study. They had no history of DM. Both groups were matched for age, gender and family history of DM. FBS was checked for all participants and FBS ³ 126mg/dl was defined as DM. Results: 35.9% of patients with HZ and 19.7% of control group had DM. There was a significant relationship between HZ and undiagnosed DM (OR=2.28, 95% CI: 1.28-4.06, p=0.0046). On the other hand, DM was 2.28 times more common in HZ patients than in normal population. Conclusion: Undiagnosed DM can cause HZ so the patients suffering from HZ but have no history of DM should be monitored for diabetes. Diabetes Mellitus Herpes Zoster Undiagnosed Diabetes Mellitus 2008 1 01 36 39 http://feyz.kaums.ac.ir/article-1-25-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Effect of vitamin E on glycemic control and lipid profile in type 2 diabetes Mina Khabaz rashidy_maryam_nr@yahoo.com Maryam Rashidi Fatemeh Kaseb Mohammad Afkhami-Ardekani Background: Type 2 diabetes is associated with elevated oxidative stress and decline in antioxidant defense. Vitamin E supplementation reduces oxidative stress level in diabetic patients. Also some studies showed that vitamin E enhances insulin sensitivity and improves lipid profile. The aim of this study was to evaluate the effect of vitamin E supplementation on glycemic control and lipid profile in type 2 diabetic patients. Materials and Methods: In this study 31 type 2 diabetic subject who referred to Yazd Diabetes Research Center with Fasting blood suger:140-200 mg/dl,2-hour postprandial BS <250 md/dl, Triglyceride <400mg/dl, Total Cholesterol ≤300 mg/dl and mild hypertension (systolic blood pressure: 140-160mmHg,diastolic BP:90-100mmHg) were selected. Subjects received vitamin E 800 IU/day for 3 months. At first and end of treatment period FBS, TC, TG, LDL, HDL, Glycated hemoglobin and fasting insulin level were measured. Results: In this study 31 type 2 diabetic patients (19 female, 12 male) with mean age 53.03 ± 8.87 years and mean duration of diabetes 2.16 ± 0.89 years were studied. Vitamin E supplementation for 3 months had no positive effect on type 2 diabetic patients. As FBS, TG and fasting insulin decreased but this decline was not significant. Also TC levels, systolic and diastolic BP changes was not remarkable. Conclusion: Results of this study showed that 800 IU vitamin E administration for 3 months could not improve blood glucose, lipids, HbA1C, fasting insulin, systolic and diastolic BP in type 2 diabetic patients. Type 2 diabetes Vitamin E Insulin Glycated hemoglobin 2008 1 01 40 45 http://feyz.kaums.ac.ir/article-1-26-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Average length of third stage of labor in singleton delivery at shabihkhani hospital, Kashan, 2005-2006 Mahboubeh Taebi Masoumeh Abedzadeh Zohreh Sadat Farzaneh Saberi Background: The third stage of labor has been described as the most dangerous stage. Concerning importance of the third stage, this study was performed to determine the length of this stage and its related factors.Material s and Methods: This cross-sectional study was carried out on 1000 deliveries in shabihkhani Hospital, in Kashan, during 2005-2006. Gestational age >20 weeks, singleton pregnancy, and vaginal delivery without any instrument were the including criteria. Data were analyzed using c 2 , OR and CI . Results: Mean and median of the third stage of labor were 6.03 and 5 minutes, respectively. There was significant association between the number of parturitions (p= 0.04), induction with oxytocin (p=0.002), analgesia during labor (pethedin) (p=0.008), and umbilical cord drainage for the third stage management (p<0.001). There was no significant association between history of abortion, gestational age, third stage management (oxytocin), fetal sex, and weight. Conclusion: Use of induction, and analgesics during labor and umbilical cord drainage increased the length of the third stage but multiparty decreased it. It is recommended to consider these factors for prediction and prevention of dangers of prolonged third stage of labor. Third stage of labor; Postpartum hemorrhage; Placenta delivery; Normal vaginal delivery 2008 1 01 46 51 http://feyz.kaums.ac.ir/article-1-27-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 The effect of pars plana lensectomy and Anterior vitrectomy on visual acuity in hereditary lens subluxation of Marfan\'s syndrome Davoud Aghadoost dawood_aghadoost@yahoo.com Maryam Jamei Seyyed Gholamabbas Mousavi Background: This study was designed to evaluate the visual results of lensectomy and Anterior Chamber intraocular lens implantation in patients with Marfan syndrome and hereditary sublaxation of lens in Matini Hospital of Kashan-Iran from 2001-2006.Materials and Methods: In an interventional case series, records of patients with hereditary sublaxation of lens with a surgical correction were reviewed. The criterion involved was low visual acuity (VA) due to uncorrectable refractive error. All patients were followed for at least 3 months. Data on age, sex, pre and post operative best corrected visual acuity (BCVA), Intraocular Pressure (IOP) and complications were recorded.Results: The study group included 19 eyes of 11 patients with mean age of 34.7 years (range of 12 to 48 years). Sixty-three percent of patients were male. All patients were followed for at least 3 months with mean of 25 months (ranging 3-60 months). Pre operation mean of BCVA was 3/10 in 82.5% post operatively (P<0.05). No visual-threatening complications such as glaucoma, hypotony or retinal detachment was observed in the studied subjects. The most common post operative complication was sterile uveitis (21.1%) which was treated successfully with medications.Conclusion: Pars plana lensectomy with implantation of AC IOL and prophylactic band in Marfan patients with hereditary sublaxation of lens improves visual acuity without serious complications. Lens sublaxation Marfan syndrome Vitrectomy Visual acuity 2008 1 01 52 55 http://feyz.kaums.ac.ir/article-1-28-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Frequency of ADHD among 3-17 year old epileptic children at Kashan in 2005 Ahamd Talebian Talebianmd@yahoo.com Hadi Khodaparast Hamzeh Sediqi Mohsen Taqaddosi Seyyed Gholamabbas Mousavi Background: Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders in children and accounts for 5 to 10% of patients who refer to pediatric psychologists. With respect to more frequency of ADHD in epileptic patients than in general population and because some of the antiepileptic drugs can cause or aggravate this disorder we conducted this study to evaluate the frequency of ADHD in the epileptic children. Materials and Methods: This descriptive cross sectional study was done on 50 epileptic children referring to neurology clinic of Kashan in 2005. Data gathered through two questionnaires containing DSM IV diagnostic criteria of ADHD, and personal history, and were analyzed by Chi square and Fisher exact tests. Results: Among 50 epileptic children 21 (42%) had ADHD (45.8% Female and 38.4%: Male). ADHD occurred in 3-7 years old children (69.2%) and the older ones (32.4%) (P = 0.025). ADHD frequency in the first child of the family was 50% and in the others was 26.9% (P = 0.024). Fifty-two percent of ADHD children and 27.5% of normal children had history of febrile seizure. In 57.1% of patients, ADHD began after epilepsy occurrence and in 42.8% existed before it. In 41.6% of children ADHD started after using antiepileptic drugs while in 33% of them ADHD was exacerbated. Phenobarbital had the main role in inducing or increasing ADHD symptoms. Conclusion: Because ADHD was more common in epileptic children than in normal population, it is recommended to perform psychiatric consultation for them. Also close attention should be paid in selecting antiepileptic drugs. ADHD Epilepsy Child Attention Deficit Disorder with Hyperactivity 2008 1 01 56 60 http://feyz.kaums.ac.ir/article-1-29-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2008 11 4 Evaluation of hearing loss and related fctors in patients referred to audiometry clinic of Matini hospital, Kashan, 2006 Ahmad Yeganehmoghaddam Mohamamd Hajijafari dr_hajijafari@yahoo.com Moireh Ghorbani Ababs Dalirian Background: Hearing loss is a common problem affecting private and social life of the involved individuals. Prevalence and type of hearing loss vary in different communities. This study was conducted to identify the frequency of hearing loss and its related factors on patients referred to audiometry clinic of Kashan University Matini hospital in 2006. Materials and Methods: In a cross sectional study from November 2005 to April 2006, 462 patients referred to the audiometry clinic were enrolled to the study. The causative mechanisms of hearing loss, with a decrease of more than 10db, were considered in 3 main categories of conductive, neuro-sensory, and mixed types on the base of audiogram charts. The data were analyzed with c2 and fisher exact tests. Results: Of 462 patients, 203 (43.9 %) had hearing loss, 53.7% of whom were male. Mean age was 33.4±19.5. Neuro-sensory hearing loss was the most common type (41.9%), followed by conductive hearing loss (38.9%) and mixed hearing loss (19.2%). The rates of bilateral and unilateral hearing loss were 65%, and 35%, respectively. Most cases had moderate (40-60 db) hearing loss. Among different factors causing hearing loss, otitis media was the most common (34%). Conclusion: hearing loss is highly prevalent. neuro-sensory loss was the most common type and otitis media the most common cause. These factors are totally treatable, so more attention should be paid to their proper treat. Audiometry Sensorineural 2008 1 01 61 67 http://feyz.kaums.ac.ir/article-1-30-en.pdf