2024-03-28T17:58:43+03:30 http://feyz.kaums.ac.ir/browse.php?mag_id=11&slc_lang=fa&sid=1
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 Evaluation of molecular genetics of glucose-6- phosphate dehydrogenase deficiency and male individuals in zanjan city during 2001-2003 Yousef Mortazavi Abdoreza Esmaeilzadeh Sadroddein Kalantari Background: Glucose-6-phosphate dehydrogenase (G6PD) is an X-Linked enzymopathy affecting about 400 million people worldwide. Neonatal jaundice, drug induced haemolysis and infection-induced haemolysis may happen in some deficient individuals and lead to considerable mortality. The distribution of G6PD deficiency and the molecular genetics of this enzyme vary widely among different ethnic groups. The aim of this study was to find out the frequency of G6PD deficiency and characterize the molecular type of this enzyme in deficient individuals in zanjan city.Materials and Methods: One thousand and five hundred unrelated normal male individuals were screened for G6PD deficiency by fluorescent spot test. DNA was extracted from peripheral white blood cells of the individuals who were deficient for G6PD.polymerase chain reaction (PCR) was used to amplify flanking regions of exons six and seven of this gene using a set of primers. The PCR products were digested by the enzyme Mboll and electrophoresed on 2.5% agarose gel.Results: Thirty three out of 1500(2.2%) individuals were shown to be deficient for G6PD enzyme. Twenty four out of 33 (72.7%) showed a mutation at nt 563 of G6PD gene which is characteristic of Mediterranean type of mutation. Nine individuals (27.3%) were negative for this mutation.Conclusion: The results of this study showed that the prevalence of G6PD deficiency was lower comparing with that of other provinces. A direct correlation has been shown between G6PD deficiency and malaria in regions in which malaria was prevalent. Since the frequency of malaria is very low in zanjan, therefore, this rate of deficiency was justifiable for this region. Despite different frequencies existing for deficiency of G6PD in central, north, northwest ant southeast regions of Iran, the results of this study and other studies carried out by us and others have shown that the prevalence for Mediterranean type of G6PD in all the above regions are approximately the same. This may indicate that the predominant G6PD mutation in Iran is of Mediterranean type and this mutation is an old mutation too. G6PD deficiency Mediterranean mutation PCR 2006 1 01 1 6 http://feyz.kaums.ac.ir/article-1-120-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 A study of nonthyroid illness (NTI) in patients admitted at intensive Care units at Hospitals of Kashan University of Medical Sciences Sayed Ali Reza Ebadi ebadi_ar@kaums.ac.ir Ali Reza Farrokhian Sayed Asghar Rasoulynejad Hossein Akbari Background: Since there are many controversies about the incidence and prevalence of thyroid hormone abnormalities in critically-ill patients, and because of lack of such information in our patients, this study was performed to determine the frequency of these abnormalities in patients admitted to Intensive Care Unit of Kashan Medical University hospitals in the second half of 2003. Materials and Methods: This descriptive study (with new data)was conducted on patients with severe illness admitted in Intensive Care Unit. The information on age, sex, primary diagnosis, vital signs was obtained. A sample of blood to assess thyroid hormone was taken too. Another sample to assess thyroid hormone was taken 8 weeks later. Results: The population under study included 99 cases with mean age of 58.04 ± 21 years, 61.6% of which were males and 49.5% of patients died in the course of admission. The prevalence of reduction in T4-T3-TSH-T3Ru on the beginning of admission was 22.2%, 31.3%, 29.3% and 22.2% respectively. The most common abnormality was decreased in T3 level and 71% of patients with this reduction died. Decrease related to T4 was 81.8% and related to simultaneous decreased of both hormones was 91.7%. The mean level of T4 was 76.10 ± 37.60 (nmol/lit) in died patients and 100.48 ± 37.84 (nmol/lit) in recovered patients (p<0.002). The measurement about T3 in died and recovered patients was 0.96 ± 0.58 (ng/ml) and 1.33 ± 0.65 (ng/ml) respectively (p<0.004). The mean of hormonal level in 50 recovered patients was 0.96 ± 0.58 (ng/ml) and 1.33 ± 0.65 (ng/ml) respectively (p<0.004). The prevalence of NTI according to hormonal assessment 8 week after discharge-related to T3,T4,T3RU and TSH was 88.9, 66.7, 100, 0 percents respectively. Conclusion: Our research showed that hormonal change in Nonthyroid illness (NTI) in intensive care unit is common, and has prognostic value. Therefore, recognition of this abnormality in critically-ill patients is needed. Experimental clinical trials are recommended to choose the appropriate approach. Nonthyroid illness (NTI) Thyoid hormone Intensive care unit (ICU) 2006 1 01 7 12 http://feyz.kaums.ac.ir/article-1-115-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 A study on the low dose effect of venous fentanyle in pain reduction due to lumbar puncture in infants Mahmoud Noori Shadkam Mir Mohammad Jalili Lumbar Puncture CHEOPS Midazolam Fentanyle 2006 1 01 13 17 http://feyz.kaums.ac.ir/article-1-117-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 Third stage of labor is one of the most important stages which can cause partum hemorrhage and maternal mortality Leili Salehi Azam Bahiraei Fateme Vasegh Background: Active management of labor in low risk women is controversial. The present research is a clinical trial study in which the researcher tries to determine the difference in the active and physiologic management of the third stage of labor. Materials and Method: The subject were divided into two group of 47.All subjects in active group received 10 unit syntocinone in 500 cc injection serum and cord immediate clamped and cut and placenta delivered by Brant-Andrews manover and the physiologic group received 1cc placebo in 500 cc serum,no clamping of the cord until pulsation had ceased and placenta delivered by minimal traction on the cord and maternal effort without Brandt-Androws manover after expulsive the placenta and membrane in view of completing were examined. Results: As a result, the case of post partum hemorrhage in physiologic group (14.587%) was higher than active group (10.64"%) but the statistical tests showed no significant difference between two groups (p=0.2945). The mean length of the third stage of labor in the physiologic group (13minute) was higher than active group (t=2.379, df=92) but the statistical test showed no significant between the two groups. The statistical tests showed no significant difference between retained placenta and piece of the placenta and membrane (p=0.2428). The statistical tests showed no significant difference between duration and complication of the third stage in two groups. Conclusion: Therefore, the study showed that the physiologic management of third stage is a good choice for managing the low risk women Third stage of labor Active and Physiologic management Postpartum hemorrhage Third stage complication 2006 1 01 18 22 http://feyz.kaums.ac.ir/article-1-121-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 Results of clinical and sonographic estimation of fetal weight Fariba Behnamfar Zohre Sadat sadat@kaums.ac.ir Sayed Gholam Abbas Moosavi Fateme Moosavi Background: Accurate estimated fetal weight (EFW) has importance in the management of labor and delivery. Estimated fetal weight was done in two sonographic and clinical ways (Palpation of abdomen). Many studies have been conducted for comparing clinical and sonographic EFW. With regard to contraindications and absence of studies in this area, this research was conducted on women admitted due to termination of pregnancy in Shabih Khani Maternity Hospital in 1383 Materials and Methods: This research as a cross-sectional study was done on 100 women with gestational 37/42-week ages admitted for termination of pregnancy. Excluded criteria consists of premature rupture of membrane, placenta abruption- placenta previa , preeclampsia, fetal abnormality , amniotic fluid disorder Clinical estimation in labor was performed by senior resident or obstetrician and sonographic estimation was performed by sonographists. The actual birth weight was determined by electronic scales and recorded in the chart immediately after delivery. Accuracy of birth weight estimation was determined by calculating the percentage error, and the proportion of estimates within 10% of the actual birth weight. Then processing of information performed by chi-square, fisher exact test and relative risk was determined Results : study on 100 pregnant woman showed mean age was 22.5 ± 4.5 and mean gestational age was . 39.2 ± 0.9 and mean birth weight was 3513 ± 370.3 .Birth weight in %10 of new born was less than 3000 gr and %12 of birth weight was more than 4000 gr . In total pregnant women clinical estimation in (83 women) 83% and sonographic estimation in (67 women) 67% was acceptable in which statically were important (P= 0.009).In birth weight less than 3000 gr sonographic estimate better than clinical estimate p<0, 03 Conclusion: regarding that most of fetus is reneged between 3000-4000 gr. accuracy of clinical estimation is often more than sonographic estimation so that we can perform EFW by simple weight and without cost. But in cases such as low birth weight that sonographic estimation of weight as direct diagnosis are defined and in obese women due to difficulty of clinical estimation , we suggest sonographic estimation to use. Clinical estimation Sonographic estimation Macrosomia Low birth weight 2006 1 01 23 26 http://feyz.kaums.ac.ir/article-1-113-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 Etiology of blindness and low vision in an OPD- Ophthalmology Clinic Setting Davoud Aghadoost aghadoost_d@kaums.ac.ir Ahmad Yeganeh Moghaddam Batool Jamei Background: To determine the cause of monocular and binocular blindness and low vision in an OPD-ophthalmology clinic setting Materials and Methods: In a prospective OPD-based cross-sectional study, 420 subjects were examined in general ophthalmology clinic in Kashan from June 2003-2004. All patients underwent dilated pupil examination by an ophthalmologist. Low vision and blindness defined as best corrected visual acuity< 20/70 (<3/10) or < 20/200 respectively. Results: Of 420 patients enrolled in this study186 (44.3%) were males. Three hundreds and two of cases were blind and 18 had low vision. Common causes of low vision and blindness in order of frequency were: cataract 39.8%, diabetic retinopathy 10.9%, myopic fundus 9.5%, amblyopia 9.3% and ARMD 7.9% The most common anatomic site of decreased vision were lens, retina, optic nerve and visual pathway Conclusion: Cataract, retinal diseases including diabetic retinopathy and myopic degeneration are the leading cause of low vision and blindness. Trauma is a significant cause of sever, unilateral vision loss, especially in the young and in newly presenting subjects. Diabetes was the leading cause of blindness among the working age group population. Blindness Low vision Cataract 2006 1 01 27 30 http://feyz.kaums.ac.ir/article-1-112-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 Bacterial vaginosis in patients referring to medical centers in shahrekord, 2004-2005 Afsane Taghriri Azar Danesh Background: Bacterial vaginosis was reported to have great influences on pregnancy and fetus health. Since the true epidemiologic profile of bacterial vaginosis is not obvious in shahrekord, the present study was performed on patients referring to medical centers, between 2004 and 2005. Materials and Methods: For this descriptive study, initial data was gathered via history, direct smear, KOH test, Variables: Bacterial vaginosis, marital status, occupation, husband’s job, signs (dysparonia, vaginal burning), direct smear, Wiff test, colour and smell and form of vaginal discharge. Results: Of 210 patients, 60 (%28/6) were revealed to be infected with bacterial vaginosis. These 53 (% 88/4) had bad odour and 33 (%55) had yellow-gray discharge and had 48 (%80) watery discharge and 25 (%41/6) had dysparonia and 11 (%18/3) had vaginal burning .60 (%100) had positive direct smear and 29 (%48/3) had Whiff test or positive KOH test .There exists association between result of direct smear and Whiff test. This is not similar to those patients with Whiff test and direct smear. There exists association between bacterial vaginosis and bad smell discharge, dysparonia, vaginal burning and yellow-gray discharge and no association between bacterial vaginosis and occupation, marital status and husband’s job. Conclusion: Bacterial vaginosis is a common infection in Shahrekord .it is associated with preterm delivery and premature birth. We recommend that for control and prevention of bacterial vaginosis at pregnancy, educational and hygienic programs should be considered regarding all patients in Shahrekord. Epidemiology Bacterial Vaginosis Parturient Shahrekord 2006 1 01 31 35 http://feyz.kaums.ac.ir/article-1-118-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 Effect of nutrition education on metabolic control of subjects with type 1 diabetes Nadia Rezaei Faride Tahbaz Masoud Kimiagar Hamid Alavi Majd Background: Medical-nutritional management can reduce the risk of progression of complications. Therefore the aim of this study was to evaluate the effect of nutrition education on metabolic control of patients with type 1 diabetes in Aligoodarz in year 2001. Methods and Materials: Firstly , Patients with type 1 diabetes were traced and recruited from medical centers. Then the study was performed with a semi experimental (self-control) design. Anthropometric measurements, diet survey and KAP study were conducted on patients with type 1 diabetes by a nutritionist. Biochemical indices were measured on blood and urine samples. The comparisons were made by paired t-test and MacNemar test. P values less than 0.05 were considered as significant. Results: In total, for 30 patients FBS (239.84 ±12.61 vs 183.74±91.02) and TC (224.23±60.86 vs 163.86±34.08) decreased significantly (p<0.001). Also HbA1c%, LDL-C, and 24 hr urinary protein (for all p<0.001) and serum creatinine (p<0.008) decreased significantly. Cholesterol intake decreased (p<0.01) and dietary fibre, vitamin C and folate increased significantly (for all p<0.001). Both Knowledge and Practice scores increased significantly (for both p<0.001), while Attitude was not significantly changed. Conclusion: Findings of this project highlights the importance of nutrition education of patients with type 1 diabetes for better metabolic control. Thus setting up a diabetes unit in cities like Aligoodarz is recommended, to register patients and monitor their metabolic control regularly. Nutrition education Type 1 Diabetes Metabolic control Knowledge Attitude and Practice (KAP) 2006 1 01 36 42 http://feyz.kaums.ac.ir/article-1-119-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 Accuracy and precision of body temperature measurement with infrared tympanic and axiliary thermometers compared with standard oral mercury thermometer Ahmad Khosravi Mohammad Bagher Sohrabi Hossein Haratipoor Poune Zolfaghari Background: Monitoring patients’ temperatures is an important aspect of clinical nursing. Oral temperature readings have long been considered as a gold standard. However, oral temperature measurements may be contraindicated in some patients, that is cases with level of consciousness and seizure. Axiliary and tympanic temperature monitoring are often the next choices. We decided to evaluate these methods compared with standard oral temperature readings. Materials and Methods: Subjects were a convenient sample of 81 adult patients over 17 years old in Shahrood Imam Hussein hospital. The study time course spanned a 1-mounth in December, 2004. Body temperature is measured in the evening using mercury oral and axiliary thermometers and “Omeron” tympanic thermometer.Results: From 81 patients studied, there were 35(43.2%) males and 46(56.8%) females and their mean age was 46.0 ±19.2 (range 17-85). The mean for oral temperature was 36.9±0.56°C, axiliary: 36.5±0.53 °C, tympanic: 36.5±0.49° C. Oral thermometry identified a fever in 8 of 81 (9.9%) patients. The ROC analysis for determining a cut point with 100% sensitivity is used. For axiliary measurement at 36.95 °C, 82% specificity and for tympanic measurement at 36.45 °C, 55% specificity is recorded. Alpha coronbach for reliability of tympanic thermometer is equal to 0.98. The correlation between right to right and left to right ear temperature were 0.96 and 0.94, respectively. Conclusion: We conclude that axiliary thermometer with carefully use and suitable cut point is an effective instrument. With regard to specificity of tympanic thermometer for detection of fever, we do not recommend electronic tympanic measurement. Accuracy Precision Oral thermometer Axiliary thermometer Tympanic thermometer 2006 1 01 43 49 http://feyz.kaums.ac.ir/article-1-116-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 Evaluation of bacterial contamination in medical devices and anti- bacterial resistance of isolated gram negative bacilli in shahid beheshti Hospital in Kashan, Iran, 2004 Rezvan Moniri moniri@kaums.ac.ir Mansoure Momen Heravi Background: This study was conducted for assessing the role of medical devices such as thermometers, stethoscopes, and cuffs in transmission of nosocomial infections in Shahid Beheshti Hospital in Kashan, Iran in 2004. Materials and Methods: This Descriptive study was carried out on 166 medical devices such as thermometers, stethoscopes, and cffs used in various wards of Shahid Beheshti Hospital in Kashan, Iran,2004. Samples were taken randomly from the outer surfaces of the medical instruments by use of sterile swabs poured in sterile saline. The samples immediately were transported to the microbiology laboratory of Kashan University of Medical Sciences. In laboratory, the samples were inoculated in blood agar and Eosin-Methylene Blue agar and preserved in 37° C. Identification of the isolated colonies were based on Gram staining, and biochemical standard tests such as indole, methyl red, vogesproskaur, citrate (IMViC), oxidase, and β-glucoronidase. Antimicrobial susceptibility of the isolates gram negative bacilli were performed by the disk diffusion method according to standards developed by the National Committee for Clinical Laboratory Standards (NCCL). Results: The overall contamination rate was 65.7% (109 out of 166). The contamination rates for cuffs and stethoscope at the various wards were 100%, and the overall for alcohol used as disinfectant of thermometers were 50%. The highest contamination rates of alcohol were seen in women in surgery ward about 100%. From the total 124 isolated micro-organisms, the gram positive cocci were 57 cases (%46), gram negative bacilli 33 (%26.6 ), gram negative cocci 14 (%11.3), gram positive bacilli 11 (%8.9), yeast 6 (%4.8), and fungi 3 (%2.4). The antibacterial susceptibility test were done on isolated gram negative bacilli and resistance to the first and third generations of cephalosporin, ciprofloxacin, and co-trimoxazole were notable Conclusion : According to high contamination of medical devices with gram negative bacilli and their role in spread of nosocomial infections, the use of private thermometer per patients or use of disposable cover for rectal thermometers, and periodic disinfection of the stethoscope and cuffs are reasonable ways to reduce the risk of transmission. Bacterial contamination Medical devices Antibacterial resistance 2006 1 01 50 55 http://feyz.kaums.ac.ir/article-1-114-en.pdf
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Feyz Medical Sciences Journal Feyz 1029-7855 2008-9821 2006 9 4 Evaluation of peroxide concentration in Zoolbia and Bamieh in Kashan City in 2003 – 2004 Zatollah Asemi Shima Ziya Mohammad Ali Doulati Tarane Abedi Ahmad Hosseini Hossein Yosefi Background : Peroxide is the first compound that is produced after fats and oils are oxidated. Whenever peroxide concentration reaches to a certain amount, different changes occur and volatile essences are created which make unfavoured odour and flavour in oils and fats. The present article is a report of evaluation of peroxide concentration in Zoolbia and Bamieh which was planned and applied in kashan city in 2003-2004. Materials and methods : The research was accomplished by a descriptive study on 57 samples of Bamieh and 36 samples of Zoolbia during 2 years. In this study, firstly, certain amount of sample oil was extracted by Suxeleh method, and then the amount of available peroxide in the oil was measured by titration (Sodium thiosulfate 0.02 Normal). To determine the amount of peroxide, the sodium thiosulfate consumption was measured and calculated by related formula. Statistical analyses were accomplished by use of test. Results : From total 57 samples of Bamieh, 42 samples (73.7 %) were consumable and 15 samples (26.3 %) were inconsumable. Also 19 samples of total 36 samples Zoolbia samples (52.8 %) were consumable and 17samples (47.2 %) were inconsumable. The maximum peroxide level in Zoolbia and Bamieh samples were 65 and 38.3, respectively. Conclusions : The results of this study show that most of Zoolbia and Bamieh samples had been inconsumable . According to high amount of peroxide in the most samples and also to dangerous effects that peroxide have on the health it seems that the presentation of continuos planning and practical approaches will be necessary by regional health professional. Peroxide Zoolbia Bamieh Kashan 2006 1 01 56 60 http://feyz.kaums.ac.ir/article-1-111-en.pdf