29 1029-7855 Kashan University of Medical Sciences 3274 General Effect of three months aerobic training on TCF7L2 expression in pancreatic tissue in type 2 diabetes rats induced by streptozotocin- nicotinamide Eizadi Mojtaba b Ravasi Ali Asghar c Soori Rahman d Baesi Kazem e Choubineh Sirus f b Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, I. R. Iran. c Department of Exercise Physiology, College of Physical Education and Sport Sciences, Tehran University, Tehran, I. R. Iran. d Department of Exercise Physiology, College of Physical Education and Sport Sciences, Tehran University, Tehran, I. R. Iran. e Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, I. R. Iran. f Department of Exercise Physiology, College of Physical Education and Sport Sciences, Tehran University, Tehran, I. R. Iran. 1 4 2017 21 1 1 8 25 02 2017 25 02 2017 Background: Although less is known about the molecular mechanisms responsible for its genetic compatibility, regular training is identified as a non-pharmacological treatment for obesity and type-II diabetes. This study aimed to determine the effect of a 3 months aerobic training on pancreatic TCF7L2 expression and glycemic profile in type II diabetic rats. Materials and Methods: In this experimental study, type II diabetes was induced in male Wistar rats (n=16, weight: 220±30 g) by intraperitoneal injection of streptozotocin- nicotinamide. Animals were randomly divided into Exercise (n=8) and Control (n=8) groups. Exercise group, but not Control group, was completed a 3 month aerobic training (3 sessions/week). Forty-eight hours after the last exercise session, the relative expression of pancreatic TCF7L2, fasting glucose and serum insulin were measured in two groups. Results: Compared to Control rats, exercise resulted in a significant decrease in fasting glucose in Exercise group (P=0.001). Serum insulin was increased significantly by aerobic training in Exercise group compared to Control one (P=0.014). However, pancreatic TCF7L2 expression   did not change by aerobic training (P=0.876). Conclusion: Based on these data, while we concluded that a long-term aerobic training effectively improves the glycemic profile and insulin concentration of type II diabetic rats, such improvements cannot be attributed to TCF7L2 expression in pancreatic tissue.
3294 General Optimizing conditions for the production of antifungal agents using the native Bacillus cereus SB15 Motamedi Hosein g Zahedi Elnaz h Zarei-Mahmoud Abadi Ali i g Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran. h Biotechnology and Biological Science Research Center, Shahid Chamran University of Ahvaz i Department of Mycology, Faculty of Medicine, JundiShapur University of Medical Sciences 1 4 2017 21 1 9 18 06 03 2017 06 03 2017 Background: With regard to the occurrence of fungal infections, finding new antifungal agents is necessary. Due to its biologic properties Bacillus spp. are suitable sources for this purpose. The aim of this study was to find native bacillus species with potential of antifungal agent production. Material and Methods: In this experimental study, bacillus species were isolated from heat-treated soil samples and following culturing in TSB, anti-fungal effects of their supernatants were determined by disc diffusion method. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) levels of the selected strains were obtained against two fungal pathogens. Growth curve of the isolate was obtained in different pH and temperatures. The effects of pH, temperature, carbon and nitrogen sources on antibiotic production by the isolate were also investigated. This isolate was identified through biochemical and molecular tests. Results: Three out of six bacillus isolates were able to produce the antifungal agents, among them Bacillus cereus strain SB15 showed the most significant antifungal effects against a wide range of fungi. Optimized conditions for antibiotic production by this isolate were: temperature=37˚C, pH=7, 48 h incubation and manitol and urea as the best carbon and nitrogen sources, respectively. The MIC and MFC of the produced antibiotic against Aspergillus niger were: 2 and 4 and against Aspergillus flavus 4 and 16 mg/ml, respectively. Conclusion: Based on the obtained results it may be concluded that this bacillus strain has optimum potential for antifungal agent production. The strain can be used for the control of fungal infections and also fungal growth in food industry and environment. 3276 General Effect of aqueous extract of mango kernel (Mangifera Indica) on basal activity of virgin rat uterine smooth muscle: role of muscarinic receptors Noureddini Mehdi j Dehghan-Sheibani Masoumeh k Alani Behrang l j Physiology Research Center, Kashan University of Medical Sciences, Kashan, I. R. Iran. k Hazrat -e- Ali Asghar Hospital, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. l Department of Applied Cell Sciences, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I. R. Iran. 1 4 2017 21 1 19 27 26 02 2017 26 02 2017 Background: Mango belongs to the Anacardiaceae and the extracts from its stems, leaves, fruit and kernel are reported to affect smooth muscle contractility. We studied the role of   cholinergic muscarinic receptors for the effects of aqueous extract of mango kernel (Mangifera indica) on the basal activity of virgin rat uterine smooth muscle. Materials and Methods: In this experimental study, mid-sections (n=24) of the uterine of healthy virgin rats were placed in an organ bath containing carbonated Tyrode’s solution under 1 g tension. The cumulative effects of the aqueous extracts of mango kernel (0.002, 0.02, 0.2, 2, 20, 200, and 2000 μg/mL) or extract vehicle (Tyrode’s solution) in the presence or absence of atropine were examined by isometric method using the strength, frequency and contractile activity of uterine smooth muscle. Results: The cumulative concentrations (0.002-20 µg/ml) of mango kernel aqueous extract was significantly decreased the strength, frequency and contractile activity of uterine smooth muscle, but the contractile activity was returned to the basal level at the concentrations of 200 and 2000 µg/ml. Atropine (1 µM) could not significantly change the effects of cumulative use of extract on the strength and contractile activity of uterine smooth muscle, but it significantly enhanced the contractile frequency at low concentrations. Conclusion: The effects of aqueous extract of mango kernel on the activity of the uterine smooth muscle might not be through cholinergic muscarinic receptors and atropine could enhance the effects of the extract on frequency through other receptors. 3277 General Evaluation of anticancer peptide VEGF111b secretion in HEK293 human cells Sadeghi Morteza m Hojati Zohreh n m Human Genetic Research Center, Baqiyatallah Medical Sciences University, Tehran, I. R. Iran. n Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, I. R. Iran. 1 4 2017 21 1 28 34 26 02 2017 26 02 2017 Background: VEGF111b is a new isoform of vascular endothelial growth factor (VEGF) recently considered as a new anticancer drug. The aim of this study was to evaluate the VEGF111b secretion from HEK293 cell wall in order to commercial production of this recombinant factor. Materials and Methods: After the design of VEGF111b sequence using OLIGO software and NCBI gene bank data, it was cloned into the pBUD.cE4.1 vector. The pBUD.VEGF111b recombinant vector was transfected into HEK293 cells using lipofectamine kit. Forty-eight hours after the transfection the production of VEGF111b was estimated by Western blotting and Human anti VEGF antibody. The VEGF111b secretion   into cell culture and cell lysate extract was measured using ELISA.   Results: The correct cloning of VEGF111b into pBUD.cE4.1vector was confirmed using enzymatic digestion and gel electrophoresis. The observed production of recombinant peptide in HEK293 was confirmed with 12KDa band in cell lysate extract of Western blotting. The ELISA results at 450 nanometer absorbance for cell culture media and cell lysate extract were 19.20±2.81 pg/ml and 32.87±7.42 pg/ml, respectively. However, no VEGF111b expression was observed in negative controls. Conclusion: The findings of this study indicate the powerful ability of   transformation and secretion of VEGF111b from HEK293 cell  wall to cell culture media with no breaking and proteolytic digestion. It seems that the commercial production and purification of this therapeutic peptide from HEK293 cell culture would be possible with high efficiency. 3280 General Association of Interleukin-27 gene rs153109 polymorphism and chronic hepatitis B infection Mokhtari Samira o Hosseini Seyyed Masud p Mohebbi Seyyed Reza Azimzadeh Pedram Zali Mohammad Reza o Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, I. R. Iran. p Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, I. R. Iran. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1 4 2017 21 1 35 41 27 02 2017 27 02 2017 Background: According to World Health Organization (WHO) report about 400 million people are chronically infected with hepatitis B virus (HBV). Host immune responses which are mainly controlled by cytokines, can be either effective in disease progression or control the infection. Interleukin-27 (IL-27) is a pro-inflammatory cytokine which promotes Th1 responses. Genetic variations (e.g. single nucleotide polymorphisms [SNPs]) can affect the product or activity of IL-27 gene. The aim of present study was to determine the association between IL-27 rs153109 and chronic HBV infection among the Iranian population. Materials and Methods: In this study chronic HBV patients (n=120, Anti-HBc Ab positive and HBsAg positive for more than 6 months) and controls (n=120) from healthy individuals referred to Tehran Taleghani hospital (2013-2014) were studied. Genotypes of IL-27 gene polymorphism were detected by PCR-RFLP. DNA sequencing was applied on 10% of samples to validate the genotyping results. The studied variables were polymorphism genotypes/alleles, clinical status, age and gender. Results: Results showed no statistically significant difference for patients and control groups   neither in genotype frequencies of AA among the chronic group (30%) compared to healthy controls (32.5%) (P=0.368); nor in allele frequency A) 60.4%) for patients against A 59.2% in control groups (P=0.780). Conclusion: Despite the importance of IL-27 in the immune response, the findings of this study suggests that genetic variants of IL-27 SNP 153109A/G were not associated with susceptibility to the chronic infection of HBV. 3281 General Effects of local alendronate sodium gel as an adjunct to scaling and root planing on smokers with chronic periodontitis: a pilot study Kiany Farin Montaseri Hashem Adibi Sadaf Golshah Masoud Golshah Saba Department of Periodontology, Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Department of Oral and Maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. Department of Periodontology, School of Dentistry, Kashan University of Medical Sciences, Kashan, I. R. Iran. Dental Student, Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, I. R. Iran. 1 4 2017 21 1 42 50 27 02 2017 27 02 2017 Introduction: Chemical treatments for the modulation of host response are applied along with mechanical modalities as adjunctive to periodontal treatment. The objective of this pilot study was to investigate the effects of locally-delivered alendronate sodium gel in adjunction to scaling and root planning on periodontal indices and bone formation within vertical  defects of smokers with chronic periodontitis. Methods and Materials: In this study vertical defects (n=8) with depth>5 mm have been investigated. After performing the phase I of periodontal treatment, alendronate sodium gel (1%) was applied into the periodontal pockets. The whole procedure was repeated after 4 weeks. Periodontal indices (plaque and bleeding), probing depth, gingival recession, and radiographic parameter (depth of bony defect) were measured at the beginning and following 6 months. Results: Compared to pre-treatment, the probing depth, radiographic depth of bony defect and bleeding and plaque indices were significantly reduced by local application of alendronate sodium gel (P=0.026; P=0.012 and P=0.007 respectively). Gingival recession showed significant increase (P=0.011). Conclusion: Local alendronate sodium gel (1%) plays an important role in the improvement process of periodontal indices and bone formation within vertical bony defects of smoker patients with chronic periodontitis. 3283 General Effect of garlic on plasma homocysteine level in ischemic heart disease patients Mousavian Mohadeseh Sadat Raygan Fariba Taghadosi Mohsen Moravveji Seyyed Alireza Mazochi Majid Student Research Committee, Kashan University of Medical Sciences, Kashan, I. R. Iran. 2- Kashan University of Medical Sciences, Kashan, I. R. Iran. Department of Cardiovascular, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I. R. Iran. Department of Medical Surgical Nursing, Faculty of Nursing and Midwifery, Kashan University of Medical Sciences Social Determinants of Health Research Center, Kashan University of Medical Sciences Department of Cardiovascular, Faculty of Medicine, Kashan University of Medical Sciences 1 4 2017 21 1 51 56 28 02 2017 28 02 2017 Background: Decreasing the high homocysteine level of serum as one of the risk factors of cardiovascular disease can reduce the occurrence and complications of myocardial infarction. Garlic is identified as one of the main decreasing factors of high homocysteine level. So this study was carried out to determine the garlic effect on high homocysteine level in ischemic heart disease (IHD) patients. Material and Methods: This observational study was carried out on IHD patients (n=60) attended to heart clinic of Kashan (Isfahan, Iran). Two equal groups of patients (n=30) were administered with 800 mg garlic pills daily for 6 weeks (equvalent to 4gr fresh garlic) and placebo for 6 weeks, respectively. Before and after the  intervention the plasma homocysteine, high density lipoproteine (HDL), triglyceride (TG) and low density lipoproteine (LDL) levels were measured using the ELISA) technique and TG, HDL and enzymatic techniques, respectively.     Results: The mean age of patients was 60.6±10.1 with 39 male (65%) and 21 female (35%). At the end of study the mean plasma homocysteine level was decreased from 4.6 mol/µl to 4.4 mol/µl; while in placebo group it increased from 4.5 mol/µl to 4.6 mol/µl. However, for the comparison of the effects two drugs on homocysteine, TG, HDL and LDL level, as the confounding factor, no significant difference was seen.   Conclusion: A daily garlic use of 800 mg for 6 weeks has no effect on serum   homocysteine and lipids levels. The topic requires further research in future. 3295 General Evaluation of multiple-scoring system for non-alcoholic fatty liver patients based on CK18 levels, lipid profile and liver enzymes Teimouri Nahid Nayeri Hashem Falavarjan Branch, Islamic Azad University Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, I. R. Iran. 1 4 2017 21 1 57 65 06 03 2017 06 03 2017 Background: Non-alcoholic fatty liver disease (NAFLD), the most common liver disease is usually associated with conditions such as steatosis, steatohepatitis and cirrhosis. Liver biopsy, which is the reference, gold standard and invasive method for the diagnosis of the disease may have complications. Scoring systems are among the noninvasive diagnostic methods. Numerous noninvasive scoring systems based on routinely measured clinical and laboratory parameters were provided that identifies the steatosis and advanced fibrosis in patients with NAFLD. In this study, several scoring system in patients with NAFLD were evaluated. Materials and Methods: This case-control study was carried out on sonographically established NAFLD (n=51) patients and  healthy individuals (n=30). Anthropometric factors, biochemical tests and CK-18 fragment levels were evaluated. Then the scores for hepatic steatosis index, fatty liver index, aspartate aminotransferase (AST) to platelets ratio index (APRI) were calculated. In addition, the BARD and (non-alcoholic steatohepatitis (NASH) scores were calculated. Results: In this study, as expected, except for FIB-4, there was no significant difference  between the two groups. Conclusions: Scoring systems examined in this study can help to predict the presence or absence of fibrosis and NAFLD or NASH. 3284 General Indoor and ambient air concentrations of respirable particles between two hospitals in Kashan (2014-2015) Mohammadyan Mahmoud Keyvani Sepideh Yazdani-Charati Jamshid Bahrami Abbas Yousefi-Nejad Razieh Department of Occupational Health, Faculty of Health, Mazandaran University of Medical Sciences, Sari Department of Occupational Health, Faculty of Health, Mazandaran University of Medical Sciences, Sari, I. R. Iran. Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari Department of Occupational Health, Faculty of Health, Kashan University of Medical Sciences Department of Occupational Health, Faculty of Health, Mazandaran University of Medical Sciences, Sari 1 4 2017 21 1 66 73 28 02 2017 28 02 2017 Background: The hospital environment requires special attention to provide healthful indoor air quality for protecting patients and healthcare workers against the occupational diseases. The aim of this study was to determine the concentrations of respirable particles   indoor and ambient air of two hospitals in Kashan. Materials and Method: This cross-sectional study was conducted during 3 months (Marth 2014 to May 2015). Indoor and outdoor PM10 and PM2.5 concentrations were measured four times a week in the operating room, pediatric and ICU2 (Intensive Care Unit) wards using a real time dust monitor at two hospitals. A total number of 480 samples (80 samples indoors and 40 outdoors) from wards were collected.   Results: The highest mean PM2.5 and PM10 for indoors were determined 57.61± 68.57 µg m-3 and 212.36±295.49 µg m-3, respectively. The results showed a significant relationship between PM2.5 and PM10 in the indoor and ambient air of two hospitals (P<0.05). PM2.5 and PM10 concentrations were different in all of the selected wards (P<0.05). Conclusion: The respirable particle concentrations in the indoor and ambient air in both hospitals were higher than the 24-hours WHO and US-EPA standards. Thence, utilizing sufficient and efficient air conditioning systems in hospitals can be useful in improving indoor air quality and reducing the respirable particle concentrations. 3286 General Determination of antibiotic resistance profile in Klebsiella pneumonia strains isolated from urinary tract infections of patients hospitalized in Peyambaran hospital (Tehran-Iran) Tavakol Marzieh Momtaz Hasan Department of Microbiology, Shahrekord Branch, Islamic Azad University, Shahrekord Department of Microbiology, Shahrekord Branch, Islamic Azad University, Shahrekord. I. R. Iran. 1 4 2017 21 1 74 82 01 03 2017 01 03 2017 Background: Urinary tract infection (UTI) is the second prevalent infection in human  mostly caused by Escherichia coli and Klebsiella pneumonia. The aim of this study was to determine the antibiotic resistance profile and detect the prevalence of antibiotic resistance encoding genes in K .pneumoniae isolated from UTI. Materials and Methods: Fifty K. pneumonia strains isolated from 122 UTI samples of hospitalized patients in Payambaran Hospital (Tehran, Iran) which were subjected to this study (2014) were confirmed by standard biochemical tests. Isolates were tested for susceptibility to 10 antimicrobial drugs by using disk diffusion method. Antibiotic resistance encoding genes frequently include the aadA1, aac(3)-IV, sul1, blaSHV, Cat1, cmlA, tetA, tetB, dfrA1, CITM, qnr in isolates were determined by  PCR.   Results: The highest antibiotic resistance in K. pneumoniae isolates were for Tetracycline and the lowest   resistance (2%) for Gentamicin and Imipenem. To determine the frequency of antibiotic resistant genes, 64% and 4% of isolates had tetA and Gentamicin-(aac(3)-IV)  resistant genes, respectively. Conclusion: Frequency of antibiotic resistance encoding genes may have important and basic role in the occurrence and transfer of antibiotic resistance which can be due to the indiscriminate use of antibiotics.   3285 General Effectiveness of mindfulness-based stress reduction on state/trait anxiety and quality of life in women with obesity Jafari Asghar Shahabi Seyyed Rohollah Department of Psychology, University of Kashan, Kashan, I. R. Iran. Institute for Humanities and Cultural Studies, Tehran 1 4 2017 21 1 83 93 28 02 2017 28 02 2017 Background: Obesity affects the cognitive, emotional and behavioral functions and usually produces mood and anxiety disorders. The present study aimed to determine the effectiveness of mindfulness-based stress reduction (MBSR) on promoting quality of life and decreasing anxiety among the obese women. Materials and Methods: In this pre-post-test designed experimental study with a 2 mouth follow- up, 24 obese women (BMI≥30) were randomly selected in the Obesity Treatment Center in (Tehran, Iran) and assigned in Experimental and Control groups. Data were collected using the questionnaires of anxiety of Spiel-Berger (1970) and quality of life of Viyear (1988). The MBSR interventions of Kabat-Zinn were performed for experimental group in 8 sessions, followed by the assessment of anxiety and quality of life. Results: The pre- post-test and follow- up scores for quality of life of participants in MBSR program, in terms of general health; physical limitations; physical function; social function; state anxiety and trait anxiety were: (7.66±0.88, 9.50±1.67, 9.58±1.66); (22.83±1.58, 27.91±1.16, 27±1.53); (4.50±0.67, 6.16±1.11, 5±0.95); (2.91± 0.28, 5.91±0.66, 5.75±0.38); (52.25±3.51, 43.08±2.39, 44±2.29) and (68.08±1.78, 46.75±1.71, 47.25±2), respectively. The scores of quality of life was significantly increased in participants in MBSR compared to the Control group (P<0.01). In addition, the scores of state and trait anxiety were significantly decreased (P<0.01). Conclusion: The results of research provide some evidence to suggest that MBSR is an appropriate therapy for promoting quality of life and decreasing anxiety in obese women. 3287 General The effect of a 12 week plyometric and soccer training on the cardiac structure and function among the 13-15 years old boys Tartibian Bakhtiar Ebrahimi-Torkamani Bahman Department of Sports Injuries and Corrective Exercise, Faculty of Physical Education and Sport Sciences, Allameh Tabataba’i University, Tehran Department of Physical Education , Faculty of Physical Education and Sport Sciences, University of Mohaghegh Ardabili, Ardabil, I. R. Iran. 1 4 2017 21 1 94 101 01 03 2017 01 03 2017 Background: Exercise plays an important role in improving cardiovascular function. Due to the increasing tendency of children to the soccer the purpose of this investigation was to examine the effects of a 12 week plyometric and soccer training on the cardiac structure and function of healthy 13-15 years old boys.   Materials and Methods: This quasi- experimental study was conducted with a pre-test and post-test design. The participants (n=20) were selected among the non-athletic healthy boys (13-15 years) from Miyaneh (East Azerbaijan, Iran). After taking informed consent the participants were voluntarily participated in two equal Training and Control groups. The participants in the Exercise group performed a 12 week plyometric and soccer training. Under basic conditions and after a 12 week follow-up using the echocardiography both groups were examined for left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD), left ventricular end diastolic posterior wall dimension­ (LVPWd), inter-ventricular septal end diastolic dimension (IVSd), stroke volume (SV), ejection fraction (EF) and cardiac output (CO). Results: After a 12 week training program the LVEDD, LVPWd and SV were significantly increased (P<0.05).  The EF in the Exercise group had no increase. Moreover, LVESD and IVSd were similar in both groups.  Conclusion: A twelve week plyometric and soccer training in 13-15 years old boys result in significant changes in some cardiac structural and functional indexes. 3288 General Frequency of catch up growth in small for gestational age infants born in Kashan during 2009-2010 Shiasi-Arani Kobra Moravveji Seyyed Alireza Najarzadeh Poran Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I. R. Iran. Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan Student Research Committee, Kashan University of Medical Sciences, Kashan 1 4 2017 21 1 102 109 01 03 2017 01 03 2017 Background: Small for gestational age (SGA) infants are at risk for low final height or weight. This study aimed to determine the frequency of catch-up growth in SGA infants. Materials and Methods: This cross-sectional study was carried out to study the infant’s growth process born in Kashan during 2009-2010. The infants with birth weight or height below 3 percentile were considered as SGA. A comprehensive history from mother’s diseases during pregnancy, birth grade, and parent’s education were provided. The children who achieved their height or weight for length above the 3th percentile (age<2 year) or BMI above the 5thpercentile (age≥2 year)  were considered as those who caught up growth. Results: One-hundred fifty one children were included in the study (mean birth weight =1931 gram, birth height=43.63 cm and gestational age=36.28 week). Eighty-five children (56.3%) were female. At the time of study, 116 (76.8%) children were above the 3rd percentile for height; 124 (82.1%) children were above the 3th percentile of weight for length or above the 5thpercentile for BMI; 20 (13.2%) children were below the third percentile for height and weight. The mean corrected age at the time of catch-up was 1.08 and 1.41 year for weight and height, respectively. Catch-up growth was associated with higher weight, height and head circumference at birth. Conclusions: The failure to weight or height catch-up growth in children born with SGA is common. Therefore, the early recognition and referral of such children is a necessity.