Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
HIIT effects on Troponin I and B-type natriuretic peptide in rats undergone radiotherapy
370
377
FA
Behzad
Aria
Department of Sport Sciences, Yazd University, Yazd, I.R. Iran.
Mohammad
Parastesh
Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, I.R. Iran.
mohamadreza
Bayatiani
Department of Radiotherapy and Medical Physics, Faculty of Para Medicine, Arak University of Medical Sciences and Khansari Hospital, Arak, I.R. Iran.
Mohammad Parastesh2, Mohammadreza Bayatiani3, Leyli Khavari Khorasani1
Department of Sport Sciences, Yazd University, Yazd, I.R. Iran.
Background: Heart damage is one of the complications of radiotherapy. Due to the favorable effect of exercise training on the heart, this study aimed to investigate the impact of HIIT training on Troponin I and B-type natriuretic peptide in rats undergone radiotherapy.
Materials and Methods: In this experimental study, 24 male Wistar rats were randomly divided into four groups: control, HIIT, radiotherapy, and radiotherapy + HIIT. After anesthesia, radiotherapy was performed using an 11 Gy dose of the linear accelerator. The training program of HIIT and HIIT + radiotherapy groups included 10 weeks of HIIT. To assess the serum levels of troponin-I and B-type natriuretic peptide (BNP), five ml of blood was taken 24 hours after the last training session. One-way ANOVA was used to analyze the data at a significance level of P<0.05.
Results: The results showed that the levels of troponin I in HIIT or radiotherapy + HIIT groups were not significantly different from the control group (P<0.05). But there was a significant difference between the radiotherapy group and the other three groups (P<0.05). Furthermore, no significant difference was observed between the BNP values of any of the groups (P<0.05).
Conclusion: Radiotherapy seems to increase troponin I, but HIIT does not have this effect and even reduces its increased levels. Also, neither HIIT nor radiotherapy has an impact on BNP. Therefore, patients undergoing radiotherapy can use HIIT as an effective therapeutic intervention.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
The effect of vitamin D intake with chitosan coating along with six weeks of resistance training and on the antioxidant defense indices of the hippocampal tissue of ovariectomized rats
378
387
FA
Mahsa
Dehghani-Menshadi
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran.
Mohammad
Azarbayjani
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran.
Sirvan
Atashak
Department of exercise physiology, Mahabad Branch, Islamic Azad University, Mahabad, I.R. Iran.
Maghsoud
Peeri
Saleh
Rahmati-Ahmadabad
Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, I.R. Iran.
Background: Menopause is a process that occurs with the permanent cessation of ovarian function in women and has many complications. This study aimed to investigate the effect of vitamin D with chitosan coating along with six weeks of resistance training on the antioxidant indices of the hippocampal tissue of ovariectomized rats.
Materials and Methods: 24 rats were randomly divided into 4 groups of 6. After ovariectomy, rats were divided into menopausal chitosan-coated vitamin D groups, menopausal exercise group, chitosan-coated vitamin D group and menopausal exercise, and menopausal control group. The training group did resistance training 5 days a week for 6 weeks. 24 hours after the last training session, the hippocampus was separated from the brain and the amounts of succinate dehydrogenase (SOD), malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured by ELISA technique. To compare the groups, one-way ANOVA test was used at the alpha level of 0.05.
Results: SOD values were significantly higher in the chitosan-coated vitamin D exercise group than the chitosan-coated vitamin D and menopausal control groups (P<0.05). TAC in the exercise-vitamin D group with chitosan coating was significantly higher than the exercise groups and the postmenopausal control group (P<0.05). Also, the MDA concentration in the exercise group was significantly higher than the vitamin D group with chitosan coating (P<0.05).
Conclusion: Resistance training prevented the increase of oxidative stress and when resistance training is combined with the simultaneous consumption of vitamin D with chitosan coating, due to the possible agonistic effect, it will have a greater effect in reducing menopausal complications and oxidative stress in postmenopausal women.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
The effect of aerobic exercise on lon protease 1 and heat shock protein 70 levels in mice with type 2 diabetes
388
397
FA
Mehrzad
Shabani
Department of Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, I.R. Iran.
Vahid
Valipour-Dehnou
Department of Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, I.R. Iran.
Mohammad Reza
Tabandeh
Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I.R. Iran
Mahdieh
Molanouri-Shamsi
Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, I.R. Iran.
Background: Heat shock protein 70 (HSP70) and lon protease 1 (LONP1) are thought to be indicators of mitochondrial stress, which is essential for cell survival. This study aimed to investigate the effect of endurance exercise on changes in HSP70 and LONP1 in diabetic mice.
Materials and Methods: This study was experimental and thirty adult mice were randomly and equally divided into three groups: control (C; n=10), diabetic (D; n=10) and diabetic-exercise (DE; n=10). Diabetes was induced by intraperitoneal injection of streptozotocin. Aerobic endurance training was performed for eight weeks. 48 hours after the last training session, glucose, insulin, HSP70 levels, LONP1 levels and insulin resistance index were measured.
Results: Insulin, blood glucose levels and insulin resistance in group DE decreased significantly compared to group D (P<0.05). Also, HSP70 protein levels in group DE increased significantly compared to group D (P<0.05) and in group D compared to group C decreased significantly (P<0.05). A period of endurance training significantly increased the expression of LONP1 protein levels in DE group compared to group D (P<0.05). LONP1 protein levels in group D increased significantly compared to group C (P<0.05), also.
Conclusion: Reports show that diabetes can decreases the levels of HSP70 and increases LONP1. Also, endurance exercise can enhance impaired mitochondrial function in diabetes by increasing the expression of HSP70 and LONP1 proteins. It also improves the insulin resistance index.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
Effect of eight weeks of aerobic training and curcumin supplementation on PGC1-alpha gene expression and mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model
398
406
FA
Alireza
Nikoozadeh
Department of Sport Sciences, Tabriz Branch, Islamic Azad University, Tabriz, I.R. Iran.
Roghayeh
Pouzesh-Jadidi
Department of Sport Sciences, Tabriz Branch, Islamic Azad University, Tabriz, I.R. Iran.
Alireza
Nourazar
Department of Basic Sciences, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz, I.R. Iran.
Masoud
Asgharpour-Arshad
Department of Sport Sciences, Tabriz Branch, Islamic Azad University, Tabriz, I.R. Iran.
Jabar
Bashiri
Department of Sport Sciences, Tabriz Branch, Islamic Azad University, Tabriz, I.R. Iran.
Background: Mitochondrial dysfunction is one of the possible mechanisms for the progression of heart disease. This study aimed to effect of eight weeks of aerobic training and curcumin supplementation on PGC1- α gene expression and cardiomyocyte mitochondrial citrate synthase in Cardiomyocytes of male rats with myocardial infarction model.
Materials and Methods: 40 male rats were randomly divided into 5 groups: healthy control, heart myocardial infarction control, aerobic exercise, supplement and exercise + supplement. The training and training+supplement groups were influenced by training on the intelligent electronic animal treadmill for 8 weeks, 5 days a week. At this time, the myocardial infarction control and supplement groups had no exercise program. First, healthy controls were killed. Expression of PGC1-α gene and mitochondrial citrate synthase using real-time PCR method, the obtained data were analyzed using Shapiro-Wilk test, two-way and one-way analysis of variance and Tukey's post hoc test.
Result: Results showed that the expression of PGC1-α and citrate synthase of cardiomyocytes in the groups trained with and without curcumin consumption is significantly higher than the supplemented and myocardial infarction control groups (P=0.001). No significant difference was observed between the two groups of exercise and exercise + supplement. The expression of both genes in the myocardial infarction control group was lower than that of healthy controls (P≤0.05).
Conclusion: Eight weeks of aerobic exercise alone and in combination with curcumin increased the expression of PGC1-α gene and citrate synthase. The combined effect of exercise and curcumin were nonsignificantly greater.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
Effect of eight weeks of high-intensity intermittent training (HIIT) and low- intensity endurance training (LIET) with a high-fat diet on the expression of PPARα and PLIN5 of skeletal tissue in overweight male rats
407
415
FA
Samira
Sadeghi
Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, I.R. Iran.
Farzaneh
Taghian
Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, I.R. Iran.
Background: Obesity is a metabolic disorder in which proteins involved in fat metabolism are altered. Because obesity is a growing disease among people living in today's societies, the purpose of this study was to compare the effects of 8 weeks of high-intensity intermittent training and low- intensity endurance training on PPARα and PLIN5 gene expression in skeletal muscle of overweight rats.
Materials and Methods: Forty male Wistar rats, 5 weeks old, weighing 148.4 ±22.8 g were randomly divided into four equal groups (n=10): control, LIET, HIIT which fed high fat diet, and sham group which fed standard diet. Forty-eight hours after the end of the training program (eight weeks of intense intermittent exercise or HIIT and continued low-intensity exercise or (LIET) the rat adipose tissue was isolated under sterile conditions. Finally, expression levels of PPARα and PLIN5 of skeletal tissue were measured by the Real-time PCR method.
Results: The data indicated that the expression level of the PPARα and PLIN5 was significantly increased in HIIT and LIET groups compared to the control group (P= 0.001).
Conclusion: HIIT and LIET exercises increased the expression of the PLINS gene in skeletal muscle by increasing the expression of the PPARα gene in lipid droplets of skeletal muscle.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
The effect of high intensity interval training and caloric restriction on inflammatory factors and periplipin3 visceral adipose tissue in male Wistar rats with type 2 diabetes
416
423
FA
Arash
Alimoradi
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences٫ Central Tehran Branch٫ Islamic Azad University٫ Tehran٫ I.R. Iran.
Hasan
Mateen-Homaie
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences٫ Central Tehran Branch٫ Islamic Azad University٫ Tehran٫ I.R. Iran.
Saleh
Rahmati
Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, I.R. Iran.
Background: There is ample evidence in the study of the association of inflammatory reactions with the pathogenesis and complications of diabetes, especially hyperlipidemia and atherosclerosis. This study aimed to the effect of high intensity interval training and caloric restriction on inflammatory factors and PLIN3 visceral adipose tissue in male diabetic rats.
Materials and Methods: 32 diabetic male Wistar rats was randomly divided into three subgroups: HIIT, control and caloric restriction. In the caloric restriction group, 40% of the calorie intake was restricted and other groups received the standard food they needed freely. Relative protein expression of PLIN3 was performed using western blot technique and TNF-α and IL-6 by ELISA. Data were analyzed by one-way ANOVA and Tukey's post hoc test.
Result: There was a significant difference between the mean of PLIN3, IL-6 and TNF-α in the three groups (P=0.001). The results of post hoc test showed a significant increase in PLIN3 and a significant decrease in IL-6 and TNF-α in the caloric restriction group and intense intermittent exercise compared to the diabetic control group (P=0.001).
Conclusion: HIIT and caloric restriction may increase lipid oxidation by increasing PLIN3 expression. Considering the role of TNF-α and IL-6 in increasing insulin resistance and type 2 diabetes, reducing these factors during the present study may be helpful in preventing these metabolic diseases.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
Association between adiponectin gene single nucleotide polymorphisms with age of diabetes onset and initiating insulin therapy in patients with type 2 diabetes
424
434
FA
Elaheh
Mamashli
Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, I.R. Iran.
Farnaz
Seifi-Skishahr
Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, I.R. Iran.
Marefat
Siahkouhian
Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, I.R. Iran.
Manouchehr
IranparvarAlamdari
Department of Internal Medicine, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, I.R. Iran.
Asadollah
Asadi
Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, I.R. Iran.
Behzad
Davarnia
Department of Medical Genetics and Pathology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, I.R. Iran.
Background: The incidence of type 2 diabetes is growing at an early age. Genetic factors probably play an important role in the early onset of type 2 diabetes. The present study aimed to effect of single nucleotide polymorphisms of adiponectin gene rs2241766 (+45 T/G), rs1501299 (+276 G/T) and rs17300539 (-11391G/A) on the age of diabetes onset and initiating insulin therapy in patients with type 2 diabetes.
Materials and Methods: In this case-control study, 183 patients with type 2 diabetes and 155 healthy individuals participated. Demographic and anthropometric data were collected. Genotyping was performed by using amplification refractory mutation system-PCR (ARMS-PCR). Data were analyzed by using SPSS software (version 26).
Results: According to results, in rs2241766 (SNP+45 T/G), the age of onset of diabetes and age of starting insulin therapy in the TG genotype carriers was significantly less than in TT genotype carriers (Respectively P=0.035, P=0.048). In SNP+45 T/G, 48.6% of patients with diabetes onset age<35 years were carrying the TG genotype (P=0.013). TG genotype (OR=2.381, 95% CI:1.430–7.994, P=0.006) was associated with the significantly increased risk of diabetes onset age <35 years.
Conclusion: According to the results of the present study, SNP+45 T/G of the adiponectin gene has a significant effect on the early onset of T2DM as well as the rapid progression of the disease. Evaluation of effective genetic variants can be useful in pre-diabetes screening for early detection and prevention.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
The effect of the high intensity interval training on endothelial function concentrating on alterations in miR-16 expression, total antioxidant capacity and serum malondialdehyde in the obese men
435
445
FA
Hamidreza
Zolfi
Department of Physical Education and Sport Sciences, Technical and Vocational University (TVU), Tehran, I.R. Iran.
Amir
Shakib
Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, I.R. Iran.
Background: Endothelial dysfunction, caused by obesity, can be regarded as the initial step in the development of the cardiovascular disease. Hence, the current study aimed to the effects of HIIT exercises on miR-16 induced endothelial function, total antioxidant capacity (TAC) and serum malondialdehyde (MDA) in the obese men.
Materials and Methods: 24 obese male volunteers, with a mean age of 44 years and BMI>30, were randomly divided into the training and control groups. The eight-week HIIT training group did circular exercises, including (Long Knee, Butterfly, Burpy, kettlebell snatch, and Scott Goblet), with an intensity of 80-90 % of Karvonen heart rate (first four weeks: three sessions and second four weeks: four sessions per week). Blood samples were taken from the subjects 48 hours before and after the last training session to analyze miR-16, NO, serum MDA, and TAC indices of the subjects.
Results: Eight weeks of HIIT training in the training group caused a significant increase in NO and TAC values and a significant decrease in serum MDA compared to the pre-test values. (P<0.05). Furthermore, compared to the control group, a significant decrease in miR-16 and MDA levels was observed and a significant increase in serum NO and TAC was observed in the training group (P<0.05).
Conclusion: HIIT training apparently alter serum NO levels by affecting miR-16 levels and reducing oxidative stress caused by obesity and can prevent from outbreak and development of the cardiovascular disease by improving endothelial function.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
Comparison the effectiveness of cognitive behavioral therapy focused on insomnia with mindfulness based cognitive therapy and Fordyce happiness training on affective capital in women with migraine headache
446
456
FA
Aida
Elham
Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, I.R. Iran.
Mohsen
Golparvar
Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, I.R. Iran.
Illnaz
Sajjadian
Department of Psychology, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, I.R. Iran.
Background: Increasing affective capital in women with migraine headache is one of the strategies to promote mental health in these patients. So this study aimed to comparison the effectiveness of cognitive behavioral therapy focused on Insomnia with mindfulness based cognitive therapy and Fordyce happiness training on affective capital in women with migraine headache
Materials and Methods: This study was a quasi-experimental type with a pre-test, post-test design with a two-month follow-up with three experimental groups and one control group. The statistical population included women with migraines who referred to the psychiatric centers of Kerman city in 2020. Among them, 60 people were selected via a convenience sampling method, and then they were randomly assigned to three experimental and one control groups (each with 15 participants). Experimental groups participated in cognitive behavioral therapy focused on insomnia and mindfulness based cognitive therapy and Fordyce happiness training. To measure the dependent variable of the research, Golparvar affective capital questionnaire was used. The data were analyzed using repeated measures analysis of variances through SPSS version 24.
Results: The results showed that there is no significant difference between the effectiveness of cognitive behavioral therapy focused on insomnia, mindfulness based cognitive therapy and Fordyce happiness training on increasing affective capital (P=1), and all three treatments are equally effective in increasing affective capital (P=0.001).
Conclusions: cognitive behavioral therapy focused on insomnia, mindfulness based cognitive therapy and Fordyce happiness training can be used in psychiatric centers to increase the affective capital of women with migraine.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
Effectiveness of compassion-enriched acceptance and commitment therapy on depression, stress, and anxiety in opioid addicts receiving methadone maintenance compared to Venlafaxine combination therapy
457
465
FA
mehdi
shomaliahmadabadi
Department of Education, Ardakan, Yazd, I.R. Iran.
seyedreza
AhmadiMehrabadi
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran.
Mohsen
Zabihi
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran.
Ghasem
Dastjerdi
Department of Psychiatry, Faculty of Medicine, Taft Psychiatry Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran
Zahra
Movahedian
Department of Education, Ardakan, Yazd, I.R. Iran.
Atefe
Barkhordari-Ahmadabadi
Master of Psychology, Payame Noor University, Meybod, Yazd, I.R. Iran.
Background: Psychological problems can reduce the effectiveness of opioid withdrawal, so complementary therapies are used to increase the effectiveness of treatment in these patients. In this study, the addition of the "compassion-enriched acceptance and commitment" psychotherapy method to Venlafaxine to control depression, stress, and anxiety in opioid addicts receiving methadone maintenance treatment (MMT) was investigated.
Materials and Methods: This study is a clinical trial with pre-test and post-test design. Forty opioid addicts treated with MMT were selected by voluntary sampling method and after matching were divided into two groups (n=20), including Venlafaxine alone and Venlafaxine in combination with compassion-enriched acceptance and commitment. Patients were evaluated on the DASS21 anxiety-stress-depression questionnaire. Data were analyzed using chi-square, paired and independent t-tests, and analysis of covariance with a 95% confidence interval.
Results: Findings showed that both intervention methods were effective on depression, anxiety and stress (P<0.05). However, combination therapy of compassion-enriched acceptance and commitment therapy with Venlafaxine had a greater effect on depression, anxiety, and stress in patients undergoing methadone maintenance treatment (P<0.05).
Conclusion: Adding compassion-enriched acceptance and commitment Psychotherapy to Venlafaxine improves the control of depression, anxiety, and stress in opioid addicts under MMT and can be used as an effective method in the treatment of mental disorders in these patients.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
Determination of apolipoprotein E genotyping in diabetic patients with cardiovascular diseases with allele specific PCR method
466
473
FA
Bahareh
Rashidian
Department of Biotechnology, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran.
Zahra
Rezvani
Department of Biotechnology, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran.
Background: Apolipoprotein E (ApoE) is one of the several important lipoproteins in lipid metabolism, and many studies have been conducted on it. In various studies, the role of this protein in diseases such as Alzheimer's disease, cardiovascular disease, diabetes and immune deficiency diseases such as AIDS have been addressed. The gene is a polymorphic apolipoprotein with three transcripts or different alleles called e2, e3 and e4. These three alleles have six genotypes E2E2, E2E3, E2E4, E3E3, E3E4 and E4E4 with different frequency in the population. Depending on the demographic, geographic and racial characteristics of these genotypes, they are seen with varying frequency in the population, which is in any case the highest frequency related to E3E3. In this study determinated apolipoprotein E genotyping in diabetic patients with cardiovascular diseases with allele specific PCR method.
Materials and Methods: This study was performed on 107 blood samples of diabetic patients with cardiovascular disease living in Kashan. To determine the genotype of this gene, allele specific PCR with five primers was used and then the pattern of bands in electrophoresis was used.
Results: The results show that in this population (diabetic patients with cardiovascular disease living in Kashan), as in most Iranian and world populations, the most genotype is E3E3. Also, the frequency of e2, e3 and e4 alleles is 5.1, 79 and 15.9%, respectively.
Conclusion: This study shows that there is an average impact of this genotype on lipoproteins of plasma or types of CVD, so it can be helpful to predict and prevent diseases associated with this genotype.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
Comparison of paraclinical finding of COVID-19 in children and adolescents with adults admitted to Shahid Beheshti hospital in Kashan from 2020 until 2021
474
482
FA
Payam
NasehGhafoori
Department of Pediatrics, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Mina
Nekoei
Department of Pediatrics, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Ali
Azimi
Department of Pediatrics, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Background: COVID-19 is an emerging viral disease that has led to many deaths worldwide over the past 2 years. However, due to the lower incidence of the disease in children, the information available to compare children and adults with COVID-19 is still limited. Therefore, this study was designed to compare the paraclinical findings of children and adults with COVID-19.
Materials and Methods: After extracting laboratory findings, CT scan and outcome of hospitalization of children and adults hospitalized due to COVID-19 in Shahid Beheshti hospital in Kashan from March 2020 to March 2021 through HIS and PACS systems, all this information were compared between children and adults.
Results: After analyzing the data of 15 children and 66 adults, it was observed that increased CRP (P=0.030), LDH (P=0.002) and lymphopenia (P<0.001) and hyponatremia (P=0.030) were higher in adults but increased creatinine (P<0.001) was observed more in children. Also, ground-glass opacity (P=0.020) was observed more in children than adults, but Halo sign (P=0.001) and lung severity score (P<0.001) was higher in adults.
Conclusion: Children and adults with COVID-19 differ in many ways, including CRP, LDH, lymphocyte, sodium, and creatinine laboratory tests. This difference is seen in some radiological findings, and the lung severity score on CT scans of adults is higher than children, also.
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
26
4
2022
8
1
Evaluation the epidemiologic of patients with COVID-19 delta variant admitted to Shahid Beheshti hospital in Kashan
483
490
FA
Zahra
Soleimani
Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Habibollah
Rahimi
Department of Biostatistics and Epidemiology, Faculty of Public Health, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Negar
Maleki
Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Roozbeh
Esalatmanesh
Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. Iran.
Kamal
Esalatmanesh
Department of Internal Medicine, Faculty of medicine, kashan university of medical sciences, Kashan, I.R. Iran.
Background: Outbreaks of a new virus called COVID-19 have been reported in China since late December 2019. This study was performed to evaluate the demographic, clinical, paraclinical findings and outcome of patients with the COVID-19 delta strain.
Materials and Methods: In this case-series study, 239 patients with delta strain of COVID-19 with positive PCR were selected. The patients' files contained demographic information, clinical symptoms, paraclinical findings and outcome. The collected data were analyzed through SPSS software.
Results: Among the studied patients, women were the most frequent with 53.6% and more than half of the patients were over 50 years old. The majority of patients had blood group O (45.2%), and nearly 60% of patients had at least one underlying disease, of which high blood pressure, diabetes and cardiovascular disease are the most common. Nearly 90% of patients did not receive the vaccine. The most common clinical symptoms included fever (60.3%), cough (59.8%) and dyspnea (50.2%). Nearly 90% of patients experienced mild to severe lung involvement, and nearly 75% of patients were in the moderate to severe range of the severity of the COVID-19 disease. Finally, 13 patients (5.4%) died.
Conclusion: Considering that most of the patients did not receive the vaccine and also the majority of them were in the moderate to severe phase of the disease, the necessity of receiving the vaccine to prevent the disease of COVID-19 is clear.